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Efficacy of Spirulina platensis in improvement of the reproductive performance and easing teratogenicity in hyperglycemic albino mice.

Pankaj PP - Indian J Pharmacol (2015 Jul-Aug)

Bottom Line: Diabetes was induced by intra-peritoneal administration of AXN.Litter counts, estrous cycles, percent survival of litter, and gestation length were recorded.These findings suggest that SP is effective in improving the reproductive performance and easing teratogenic effects in diabetic mice and hence warrants further detailed dose-dependent studies to understand its mechanism of action.

View Article: PubMed Central - PubMed

Affiliation: Department of Zoology, Nagaland University, Lumami, Nagaland, India.

ABSTRACT

Objectives: The present study evaluates the therapeutic efficacy of cell suspension of Spirulina platensis (SP) on estrous cycle, fetal development and embryopathy in alloxan (AXN) induced hyperglycemic mice.

Materials and methods: Diabetes was induced by intra-peritoneal administration of AXN. Mice with blood glucose level above 200 mg/dl were divided into Group I (control), Group II (diabetic control), Group III (diabetic control mice fed with SP), and Group IV (control mice fed with SP). Litter counts, estrous cycles, percent survival of litter, and gestation length were recorded.

Results: In hyperglycemic mice, a significant (P < 0.05) increase in duration of diestrus (14.48%), estrus (84.21%), and metestrus (164.15%) with concomitant decrease in proestrus phase by 26.13% was recorded when compared with control. Reduction in litter count and survival of litter was 68.67% and 88.38%, respectively, whereas gestation length increased to 14.51% day in diabetic mice, but recovery in these parameters was observed (P < 0.05) when subjected to SP treatment. SP resulted in increased fertility rate from 77.5% to 82.5% and dropped off resorption of the fetus to 33.73% while the survival rate of offspring of diabetic mice went up to 88.89% from 83.61%.

Conclusions: These findings suggest that SP is effective in improving the reproductive performance and easing teratogenic effects in diabetic mice and hence warrants further detailed dose-dependent studies to understand its mechanism of action.

No MeSH data available.


Related in: MedlinePlus

Gross morphological deformity and disturbed fetal development. (a and b) Diabetic mice with defective forelimb and hind limb including digits, (c and d) puffiness of the body and venations in the ear (dorsal and ventral view), (e and f) retinopathy with altered gross morphology, (g) pattern baldness (alopecia) in F1 mice, (h and k) deformed fetus, (l) fetus with abnormal length and weight of 18 days gestation length
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Figure 3: Gross morphological deformity and disturbed fetal development. (a and b) Diabetic mice with defective forelimb and hind limb including digits, (c and d) puffiness of the body and venations in the ear (dorsal and ventral view), (e and f) retinopathy with altered gross morphology, (g) pattern baldness (alopecia) in F1 mice, (h and k) deformed fetus, (l) fetus with abnormal length and weight of 18 days gestation length

Mentions: Diabetic mice with defective forelimb and hind limb including digits [Figure 3a and b], puffiness of the body and venations in the ear [Figure 3c and d], retinopathy with altered gross morphology [Figure 3e and f], pattern baldness (alopecia) in F1 mice [Figure 3g], deformed fetus [Figure 3h–k], and fetus with abnormal length and weight during 18 days of gestation length were observed [Figure 3l].


Efficacy of Spirulina platensis in improvement of the reproductive performance and easing teratogenicity in hyperglycemic albino mice.

Pankaj PP - Indian J Pharmacol (2015 Jul-Aug)

Gross morphological deformity and disturbed fetal development. (a and b) Diabetic mice with defective forelimb and hind limb including digits, (c and d) puffiness of the body and venations in the ear (dorsal and ventral view), (e and f) retinopathy with altered gross morphology, (g) pattern baldness (alopecia) in F1 mice, (h and k) deformed fetus, (l) fetus with abnormal length and weight of 18 days gestation length
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4527067&req=5

Figure 3: Gross morphological deformity and disturbed fetal development. (a and b) Diabetic mice with defective forelimb and hind limb including digits, (c and d) puffiness of the body and venations in the ear (dorsal and ventral view), (e and f) retinopathy with altered gross morphology, (g) pattern baldness (alopecia) in F1 mice, (h and k) deformed fetus, (l) fetus with abnormal length and weight of 18 days gestation length
Mentions: Diabetic mice with defective forelimb and hind limb including digits [Figure 3a and b], puffiness of the body and venations in the ear [Figure 3c and d], retinopathy with altered gross morphology [Figure 3e and f], pattern baldness (alopecia) in F1 mice [Figure 3g], deformed fetus [Figure 3h–k], and fetus with abnormal length and weight during 18 days of gestation length were observed [Figure 3l].

Bottom Line: Diabetes was induced by intra-peritoneal administration of AXN.Litter counts, estrous cycles, percent survival of litter, and gestation length were recorded.These findings suggest that SP is effective in improving the reproductive performance and easing teratogenic effects in diabetic mice and hence warrants further detailed dose-dependent studies to understand its mechanism of action.

View Article: PubMed Central - PubMed

Affiliation: Department of Zoology, Nagaland University, Lumami, Nagaland, India.

ABSTRACT

Objectives: The present study evaluates the therapeutic efficacy of cell suspension of Spirulina platensis (SP) on estrous cycle, fetal development and embryopathy in alloxan (AXN) induced hyperglycemic mice.

Materials and methods: Diabetes was induced by intra-peritoneal administration of AXN. Mice with blood glucose level above 200 mg/dl were divided into Group I (control), Group II (diabetic control), Group III (diabetic control mice fed with SP), and Group IV (control mice fed with SP). Litter counts, estrous cycles, percent survival of litter, and gestation length were recorded.

Results: In hyperglycemic mice, a significant (P < 0.05) increase in duration of diestrus (14.48%), estrus (84.21%), and metestrus (164.15%) with concomitant decrease in proestrus phase by 26.13% was recorded when compared with control. Reduction in litter count and survival of litter was 68.67% and 88.38%, respectively, whereas gestation length increased to 14.51% day in diabetic mice, but recovery in these parameters was observed (P < 0.05) when subjected to SP treatment. SP resulted in increased fertility rate from 77.5% to 82.5% and dropped off resorption of the fetus to 33.73% while the survival rate of offspring of diabetic mice went up to 88.89% from 83.61%.

Conclusions: These findings suggest that SP is effective in improving the reproductive performance and easing teratogenic effects in diabetic mice and hence warrants further detailed dose-dependent studies to understand its mechanism of action.

No MeSH data available.


Related in: MedlinePlus