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Efficacy of Spirulina platensis in improvement of the reproductive performance and easing teratogenicity in hyperglycemic albino mice.

Pankaj PP - Indian J Pharmacol (2015 Jul-Aug)

Bottom Line: Diabetes was induced by intra-peritoneal administration of AXN.Litter counts, estrous cycles, percent survival of litter, and gestation length were recorded.These findings suggest that SP is effective in improving the reproductive performance and easing teratogenic effects in diabetic mice and hence warrants further detailed dose-dependent studies to understand its mechanism of action.

View Article: PubMed Central - PubMed

Affiliation: Department of Zoology, Nagaland University, Lumami, Nagaland, India.

ABSTRACT

Objectives: The present study evaluates the therapeutic efficacy of cell suspension of Spirulina platensis (SP) on estrous cycle, fetal development and embryopathy in alloxan (AXN) induced hyperglycemic mice.

Materials and methods: Diabetes was induced by intra-peritoneal administration of AXN. Mice with blood glucose level above 200 mg/dl were divided into Group I (control), Group II (diabetic control), Group III (diabetic control mice fed with SP), and Group IV (control mice fed with SP). Litter counts, estrous cycles, percent survival of litter, and gestation length were recorded.

Results: In hyperglycemic mice, a significant (P < 0.05) increase in duration of diestrus (14.48%), estrus (84.21%), and metestrus (164.15%) with concomitant decrease in proestrus phase by 26.13% was recorded when compared with control. Reduction in litter count and survival of litter was 68.67% and 88.38%, respectively, whereas gestation length increased to 14.51% day in diabetic mice, but recovery in these parameters was observed (P < 0.05) when subjected to SP treatment. SP resulted in increased fertility rate from 77.5% to 82.5% and dropped off resorption of the fetus to 33.73% while the survival rate of offspring of diabetic mice went up to 88.89% from 83.61%.

Conclusions: These findings suggest that SP is effective in improving the reproductive performance and easing teratogenic effects in diabetic mice and hence warrants further detailed dose-dependent studies to understand its mechanism of action.

No MeSH data available.


Related in: MedlinePlus

(a) Fasting blood glucose level (mg/dl). n = 10, data are presented as mean ± standard error of mean, (b) therapeutic effects of Spirulina platensis on estrous cycle phases of different groups of test mice. n = 20, values are expressed as mean ± standard error of mean; superscripts ** are significantly different at P < 0.01 when compared to control. One-way analysis of variance was used followed by the post-hoc Tukey multiple comparison test
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Figure 1: (a) Fasting blood glucose level (mg/dl). n = 10, data are presented as mean ± standard error of mean, (b) therapeutic effects of Spirulina platensis on estrous cycle phases of different groups of test mice. n = 20, values are expressed as mean ± standard error of mean; superscripts ** are significantly different at P < 0.01 when compared to control. One-way analysis of variance was used followed by the post-hoc Tukey multiple comparison test

Mentions: FBGL of control animals ranged from 78.33 ± 3.88 to 83.02 ± 3.58 mg/dl during experimental period which later increased significantly (P < 0.01) to 273% at 21 days in diabetic mice [Figure 1a]. Decrease in the FBGL was observed when diabetic mice fed with SP (P < 0.01). FBGL decreased to 61% in diab + SP at 21 days. However, SP treated control mice showed an insignificant change in FBGL.


Efficacy of Spirulina platensis in improvement of the reproductive performance and easing teratogenicity in hyperglycemic albino mice.

Pankaj PP - Indian J Pharmacol (2015 Jul-Aug)

(a) Fasting blood glucose level (mg/dl). n = 10, data are presented as mean ± standard error of mean, (b) therapeutic effects of Spirulina platensis on estrous cycle phases of different groups of test mice. n = 20, values are expressed as mean ± standard error of mean; superscripts ** are significantly different at P < 0.01 when compared to control. One-way analysis of variance was used followed by the post-hoc Tukey multiple comparison test
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4527067&req=5

Figure 1: (a) Fasting blood glucose level (mg/dl). n = 10, data are presented as mean ± standard error of mean, (b) therapeutic effects of Spirulina platensis on estrous cycle phases of different groups of test mice. n = 20, values are expressed as mean ± standard error of mean; superscripts ** are significantly different at P < 0.01 when compared to control. One-way analysis of variance was used followed by the post-hoc Tukey multiple comparison test
Mentions: FBGL of control animals ranged from 78.33 ± 3.88 to 83.02 ± 3.58 mg/dl during experimental period which later increased significantly (P < 0.01) to 273% at 21 days in diabetic mice [Figure 1a]. Decrease in the FBGL was observed when diabetic mice fed with SP (P < 0.01). FBGL decreased to 61% in diab + SP at 21 days. However, SP treated control mice showed an insignificant change in FBGL.

Bottom Line: Diabetes was induced by intra-peritoneal administration of AXN.Litter counts, estrous cycles, percent survival of litter, and gestation length were recorded.These findings suggest that SP is effective in improving the reproductive performance and easing teratogenic effects in diabetic mice and hence warrants further detailed dose-dependent studies to understand its mechanism of action.

View Article: PubMed Central - PubMed

Affiliation: Department of Zoology, Nagaland University, Lumami, Nagaland, India.

ABSTRACT

Objectives: The present study evaluates the therapeutic efficacy of cell suspension of Spirulina platensis (SP) on estrous cycle, fetal development and embryopathy in alloxan (AXN) induced hyperglycemic mice.

Materials and methods: Diabetes was induced by intra-peritoneal administration of AXN. Mice with blood glucose level above 200 mg/dl were divided into Group I (control), Group II (diabetic control), Group III (diabetic control mice fed with SP), and Group IV (control mice fed with SP). Litter counts, estrous cycles, percent survival of litter, and gestation length were recorded.

Results: In hyperglycemic mice, a significant (P < 0.05) increase in duration of diestrus (14.48%), estrus (84.21%), and metestrus (164.15%) with concomitant decrease in proestrus phase by 26.13% was recorded when compared with control. Reduction in litter count and survival of litter was 68.67% and 88.38%, respectively, whereas gestation length increased to 14.51% day in diabetic mice, but recovery in these parameters was observed (P < 0.05) when subjected to SP treatment. SP resulted in increased fertility rate from 77.5% to 82.5% and dropped off resorption of the fetus to 33.73% while the survival rate of offspring of diabetic mice went up to 88.89% from 83.61%.

Conclusions: These findings suggest that SP is effective in improving the reproductive performance and easing teratogenic effects in diabetic mice and hence warrants further detailed dose-dependent studies to understand its mechanism of action.

No MeSH data available.


Related in: MedlinePlus