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Neuroprotective potential of Beta vulgaris L. in Parkinson's disease.

Nade VS, Kawale LA, Zambre SS, Kapure AB - Indian J Pharmacol (2015 Jul-Aug)

Bottom Line: Pretreatment with MEBV (200 and 300 mg/kg) significantly reduced the intensity of muscular rigidity, duration of catalepsy, akinesia, the number of tremors, VCMs, and increase fighting behavior.MEBV significantly reduced LPO level and restored the defensive antioxidant enzymes SOD and CAT in rat brain.The results indicated the protective role of B. vulgaris against PD.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, MVP Samaj's College of Pharmacy, Nashik, Maharashtra, India.

ABSTRACT

Objective: The objective was to investigate the neuroprotective role of Beta vulgaris in Parkinson's disease (PD).

Materials and methods: PD was induced by administration of reserpine (5 mg/kg/day, i.p for 5 consecutive days), haloperidol (1 mg/kg, i.p.), and tacrine (2.5 mg/kg, i.p.) in experimental animals. The symptoms of PD such as tremors, akinesia, rigidity, catalepsy, and vacuous chewing movements (VCMs) were evaluated. Foot shock-induced aggression (FSIA) model was used to confirm anti-parkinsonian activity. The methanolic extract of Beta vulgaris (MEBV) was administered at doses of 100, 200, and 300 mg/kg, p.o. The combination of L-dopa and carbidopa was used as a standard drug. Behavioral studies such as locomotor activity and grip strength were determined, and oxidative stress was evaluated in FSIA model in rat brain.

Results: Pretreatment with MEBV (200 and 300 mg/kg) significantly reduced the intensity of muscular rigidity, duration of catalepsy, akinesia, the number of tremors, VCMs, and increase fighting behavior. The locomotor activity and grip strength were significantly increased by MEBV. In FSIA, the biochemical analysis of brain revealed the increased level of lipid peroxidation (LPO) and decreased levels of superoxide dismutase (SOD) and catalase (CAT). MEBV significantly reduced LPO level and restored the defensive antioxidant enzymes SOD and CAT in rat brain.

Conclusions: The results indicated the protective role of B. vulgaris against PD. The mechanism of protection may be due to augmentation of cellular antioxidants.

No MeSH data available.


Related in: MedlinePlus

Effect of Beta vulgaris on the number of fights in foot shock-induced aggression model. Each column represents as mean ± standard error of the mean (n = 6). (a) compared with vehicle treated group. (b) compared with foot-shock group **P < 0.01, ns-nonsignificant (one-way analysis of variance followed by Dunnett's test)
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Figure 2: Effect of Beta vulgaris on the number of fights in foot shock-induced aggression model. Each column represents as mean ± standard error of the mean (n = 6). (a) compared with vehicle treated group. (b) compared with foot-shock group **P < 0.01, ns-nonsignificant (one-way analysis of variance followed by Dunnett's test)

Mentions: Administration of MEBV (300 mg/kg) showed significantly (P < 0.01) increase in the number of fights in FSIA, as compared with the vehicle group. L-dopa-carbidopa treated group also showed an increase in the number of fights [Figure 2].


Neuroprotective potential of Beta vulgaris L. in Parkinson's disease.

Nade VS, Kawale LA, Zambre SS, Kapure AB - Indian J Pharmacol (2015 Jul-Aug)

Effect of Beta vulgaris on the number of fights in foot shock-induced aggression model. Each column represents as mean ± standard error of the mean (n = 6). (a) compared with vehicle treated group. (b) compared with foot-shock group **P < 0.01, ns-nonsignificant (one-way analysis of variance followed by Dunnett's test)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4527062&req=5

Figure 2: Effect of Beta vulgaris on the number of fights in foot shock-induced aggression model. Each column represents as mean ± standard error of the mean (n = 6). (a) compared with vehicle treated group. (b) compared with foot-shock group **P < 0.01, ns-nonsignificant (one-way analysis of variance followed by Dunnett's test)
Mentions: Administration of MEBV (300 mg/kg) showed significantly (P < 0.01) increase in the number of fights in FSIA, as compared with the vehicle group. L-dopa-carbidopa treated group also showed an increase in the number of fights [Figure 2].

Bottom Line: Pretreatment with MEBV (200 and 300 mg/kg) significantly reduced the intensity of muscular rigidity, duration of catalepsy, akinesia, the number of tremors, VCMs, and increase fighting behavior.MEBV significantly reduced LPO level and restored the defensive antioxidant enzymes SOD and CAT in rat brain.The results indicated the protective role of B. vulgaris against PD.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, MVP Samaj's College of Pharmacy, Nashik, Maharashtra, India.

ABSTRACT

Objective: The objective was to investigate the neuroprotective role of Beta vulgaris in Parkinson's disease (PD).

Materials and methods: PD was induced by administration of reserpine (5 mg/kg/day, i.p for 5 consecutive days), haloperidol (1 mg/kg, i.p.), and tacrine (2.5 mg/kg, i.p.) in experimental animals. The symptoms of PD such as tremors, akinesia, rigidity, catalepsy, and vacuous chewing movements (VCMs) were evaluated. Foot shock-induced aggression (FSIA) model was used to confirm anti-parkinsonian activity. The methanolic extract of Beta vulgaris (MEBV) was administered at doses of 100, 200, and 300 mg/kg, p.o. The combination of L-dopa and carbidopa was used as a standard drug. Behavioral studies such as locomotor activity and grip strength were determined, and oxidative stress was evaluated in FSIA model in rat brain.

Results: Pretreatment with MEBV (200 and 300 mg/kg) significantly reduced the intensity of muscular rigidity, duration of catalepsy, akinesia, the number of tremors, VCMs, and increase fighting behavior. The locomotor activity and grip strength were significantly increased by MEBV. In FSIA, the biochemical analysis of brain revealed the increased level of lipid peroxidation (LPO) and decreased levels of superoxide dismutase (SOD) and catalase (CAT). MEBV significantly reduced LPO level and restored the defensive antioxidant enzymes SOD and CAT in rat brain.

Conclusions: The results indicated the protective role of B. vulgaris against PD. The mechanism of protection may be due to augmentation of cellular antioxidants.

No MeSH data available.


Related in: MedlinePlus