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Anti-hyperbilirubinemic and wound healing activity of aqueous extract of Calotropis procera leaves in Wistar rats.

Patil RA, Makwana AB - Indian J Pharmacol (2015 Jul-Aug)

Bottom Line: Statistical comparison between groups in each experiment was done with one-way analysis of variance followed by Dunnett's test.AECP showed a significant (P < 0.05) decrease in concentrations of serum total bilirubin in hyperbilirubinemic rats as well as significant (P < 0.05) increase in breaking strength and percentage wound contractions with decreased epithelization period when compared to control groups.AECP showed significant bilirubin lowering and wound healing property in Wistar rats.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, MGV's Pharmacy College, Nashik, Maharashtra, India.

ABSTRACT

Aims: The aim of this study was to evaluate the bilirubin lowering and wound healing property of aqueous extract of Calotropis procera (AECP) leaves in Wistar rats.

Materials and methods: Albino Wistar rats of either sex were used for the study. Bilirubin lowering property of C. procera leaves was evaluated using phenylhydrazine and paracetamol as inducing agents followed by measuring the concentration of serum total bilirubin in hyperbilirubinemic rats. Wound healing property was evaluated using incision and excision models by measuring tensile breaking strength, percentage wound contractions, and epithelization days, respectively.

Statistical analysis: Statistical comparison between groups in each experiment was done with one-way analysis of variance followed by Dunnett's test.

Results: AECP showed a significant (P < 0.05) decrease in concentrations of serum total bilirubin in hyperbilirubinemic rats as well as significant (P < 0.05) increase in breaking strength and percentage wound contractions with decreased epithelization period when compared to control groups.

Conclusions: AECP showed significant bilirubin lowering and wound healing property in Wistar rats.

No MeSH data available.


Related in: MedlinePlus

Effect of aqueous extract of Calotropis procera on percent wound healing in rats (N = 5 All data were subjected to one-way analysis of variance followed by Dunnett's test. *P < 0.05 was considered significant as compared to control group and Dexamethasone group, respectively. Vertical lines represent standard error of mean)
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Figure 4: Effect of aqueous extract of Calotropis procera on percent wound healing in rats (N = 5 All data were subjected to one-way analysis of variance followed by Dunnett's test. *P < 0.05 was considered significant as compared to control group and Dexamethasone group, respectively. Vertical lines represent standard error of mean)

Mentions: Percentage wound healing and epithelization days: Animals treated with DXM (0.34 mg/kg i.m. on 1st day and 0.17 mg/kg i.m. on alternative days till epithelization) and AECP (25 and 50 mg/kg p.o.) showed significant (P < 0.05) increase in wound contractions [Figure 4] and decrease in epithelization period as compared to control group [Table 2].


Anti-hyperbilirubinemic and wound healing activity of aqueous extract of Calotropis procera leaves in Wistar rats.

Patil RA, Makwana AB - Indian J Pharmacol (2015 Jul-Aug)

Effect of aqueous extract of Calotropis procera on percent wound healing in rats (N = 5 All data were subjected to one-way analysis of variance followed by Dunnett's test. *P < 0.05 was considered significant as compared to control group and Dexamethasone group, respectively. Vertical lines represent standard error of mean)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4527061&req=5

Figure 4: Effect of aqueous extract of Calotropis procera on percent wound healing in rats (N = 5 All data were subjected to one-way analysis of variance followed by Dunnett's test. *P < 0.05 was considered significant as compared to control group and Dexamethasone group, respectively. Vertical lines represent standard error of mean)
Mentions: Percentage wound healing and epithelization days: Animals treated with DXM (0.34 mg/kg i.m. on 1st day and 0.17 mg/kg i.m. on alternative days till epithelization) and AECP (25 and 50 mg/kg p.o.) showed significant (P < 0.05) increase in wound contractions [Figure 4] and decrease in epithelization period as compared to control group [Table 2].

Bottom Line: Statistical comparison between groups in each experiment was done with one-way analysis of variance followed by Dunnett's test.AECP showed a significant (P < 0.05) decrease in concentrations of serum total bilirubin in hyperbilirubinemic rats as well as significant (P < 0.05) increase in breaking strength and percentage wound contractions with decreased epithelization period when compared to control groups.AECP showed significant bilirubin lowering and wound healing property in Wistar rats.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, MGV's Pharmacy College, Nashik, Maharashtra, India.

ABSTRACT

Aims: The aim of this study was to evaluate the bilirubin lowering and wound healing property of aqueous extract of Calotropis procera (AECP) leaves in Wistar rats.

Materials and methods: Albino Wistar rats of either sex were used for the study. Bilirubin lowering property of C. procera leaves was evaluated using phenylhydrazine and paracetamol as inducing agents followed by measuring the concentration of serum total bilirubin in hyperbilirubinemic rats. Wound healing property was evaluated using incision and excision models by measuring tensile breaking strength, percentage wound contractions, and epithelization days, respectively.

Statistical analysis: Statistical comparison between groups in each experiment was done with one-way analysis of variance followed by Dunnett's test.

Results: AECP showed a significant (P < 0.05) decrease in concentrations of serum total bilirubin in hyperbilirubinemic rats as well as significant (P < 0.05) increase in breaking strength and percentage wound contractions with decreased epithelization period when compared to control groups.

Conclusions: AECP showed significant bilirubin lowering and wound healing property in Wistar rats.

No MeSH data available.


Related in: MedlinePlus