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Anti-hyperbilirubinemic and wound healing activity of aqueous extract of Calotropis procera leaves in Wistar rats.

Patil RA, Makwana AB - Indian J Pharmacol (2015 Jul-Aug)

Bottom Line: Statistical comparison between groups in each experiment was done with one-way analysis of variance followed by Dunnett's test.AECP showed a significant (P < 0.05) decrease in concentrations of serum total bilirubin in hyperbilirubinemic rats as well as significant (P < 0.05) increase in breaking strength and percentage wound contractions with decreased epithelization period when compared to control groups.AECP showed significant bilirubin lowering and wound healing property in Wistar rats.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, MGV's Pharmacy College, Nashik, Maharashtra, India.

ABSTRACT

Aims: The aim of this study was to evaluate the bilirubin lowering and wound healing property of aqueous extract of Calotropis procera (AECP) leaves in Wistar rats.

Materials and methods: Albino Wistar rats of either sex were used for the study. Bilirubin lowering property of C. procera leaves was evaluated using phenylhydrazine and paracetamol as inducing agents followed by measuring the concentration of serum total bilirubin in hyperbilirubinemic rats. Wound healing property was evaluated using incision and excision models by measuring tensile breaking strength, percentage wound contractions, and epithelization days, respectively.

Statistical analysis: Statistical comparison between groups in each experiment was done with one-way analysis of variance followed by Dunnett's test.

Results: AECP showed a significant (P < 0.05) decrease in concentrations of serum total bilirubin in hyperbilirubinemic rats as well as significant (P < 0.05) increase in breaking strength and percentage wound contractions with decreased epithelization period when compared to control groups.

Conclusions: AECP showed significant bilirubin lowering and wound healing property in Wistar rats.

No MeSH data available.


Related in: MedlinePlus

Effect of aqueous extract of Calotropis procera on serum aspartate transaminase levels in paracetamol treated rats on day 1, 5, and 10 (n = 5. All data subjected to one-way analysis of variance followed by Dunnett's test. #P < 0.05 considered significant as compared to control group. *P < 0.05 considered significant as compared to phenylhydrazine group. @P < 0.05 considered significant as compared to day 1. $P < 0.05 considered significant to day 5)
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Figure 3: Effect of aqueous extract of Calotropis procera on serum aspartate transaminase levels in paracetamol treated rats on day 1, 5, and 10 (n = 5. All data subjected to one-way analysis of variance followed by Dunnett's test. #P < 0.05 considered significant as compared to control group. *P < 0.05 considered significant as compared to phenylhydrazine group. @P < 0.05 considered significant as compared to day 1. $P < 0.05 considered significant to day 5)

Mentions: Animals treated with paracetamol (2 g/kg p.o.) showed significant (P < 0.05) increase in serum level of ALT and AST on day 5 compared to day 1 and significant (P < 0.05) decrease in serum level of ALT and AST on day 10 compared to day 5. Animals showed significant (P < 0.05) increase in serum levels of ALT and AST compared to vehicle treated group. Hyperbilirubinemic rats treated with Silymarin (100 mg/kg p.o.) and AECP (25 and 50 mg/kg p.o.) showed significant (*P < 0.05) decrease in serum levels of ALT and AST compared to the paracetamol treated group on day 10 of study [Figures 2 and 3].


Anti-hyperbilirubinemic and wound healing activity of aqueous extract of Calotropis procera leaves in Wistar rats.

Patil RA, Makwana AB - Indian J Pharmacol (2015 Jul-Aug)

Effect of aqueous extract of Calotropis procera on serum aspartate transaminase levels in paracetamol treated rats on day 1, 5, and 10 (n = 5. All data subjected to one-way analysis of variance followed by Dunnett's test. #P < 0.05 considered significant as compared to control group. *P < 0.05 considered significant as compared to phenylhydrazine group. @P < 0.05 considered significant as compared to day 1. $P < 0.05 considered significant to day 5)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4527061&req=5

Figure 3: Effect of aqueous extract of Calotropis procera on serum aspartate transaminase levels in paracetamol treated rats on day 1, 5, and 10 (n = 5. All data subjected to one-way analysis of variance followed by Dunnett's test. #P < 0.05 considered significant as compared to control group. *P < 0.05 considered significant as compared to phenylhydrazine group. @P < 0.05 considered significant as compared to day 1. $P < 0.05 considered significant to day 5)
Mentions: Animals treated with paracetamol (2 g/kg p.o.) showed significant (P < 0.05) increase in serum level of ALT and AST on day 5 compared to day 1 and significant (P < 0.05) decrease in serum level of ALT and AST on day 10 compared to day 5. Animals showed significant (P < 0.05) increase in serum levels of ALT and AST compared to vehicle treated group. Hyperbilirubinemic rats treated with Silymarin (100 mg/kg p.o.) and AECP (25 and 50 mg/kg p.o.) showed significant (*P < 0.05) decrease in serum levels of ALT and AST compared to the paracetamol treated group on day 10 of study [Figures 2 and 3].

Bottom Line: Statistical comparison between groups in each experiment was done with one-way analysis of variance followed by Dunnett's test.AECP showed a significant (P < 0.05) decrease in concentrations of serum total bilirubin in hyperbilirubinemic rats as well as significant (P < 0.05) increase in breaking strength and percentage wound contractions with decreased epithelization period when compared to control groups.AECP showed significant bilirubin lowering and wound healing property in Wistar rats.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, MGV's Pharmacy College, Nashik, Maharashtra, India.

ABSTRACT

Aims: The aim of this study was to evaluate the bilirubin lowering and wound healing property of aqueous extract of Calotropis procera (AECP) leaves in Wistar rats.

Materials and methods: Albino Wistar rats of either sex were used for the study. Bilirubin lowering property of C. procera leaves was evaluated using phenylhydrazine and paracetamol as inducing agents followed by measuring the concentration of serum total bilirubin in hyperbilirubinemic rats. Wound healing property was evaluated using incision and excision models by measuring tensile breaking strength, percentage wound contractions, and epithelization days, respectively.

Statistical analysis: Statistical comparison between groups in each experiment was done with one-way analysis of variance followed by Dunnett's test.

Results: AECP showed a significant (P < 0.05) decrease in concentrations of serum total bilirubin in hyperbilirubinemic rats as well as significant (P < 0.05) increase in breaking strength and percentage wound contractions with decreased epithelization period when compared to control groups.

Conclusions: AECP showed significant bilirubin lowering and wound healing property in Wistar rats.

No MeSH data available.


Related in: MedlinePlus