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Estimation of the plasma effect site equilibration rate constant of sufentanil in children using the time to peak effect of heart rate and blood pressure.

Song IK, Lee JH, Jung S, Kim JT, Kim HS - Indian J Pharmacol (2015 Jul-Aug)

Bottom Line: We estimated ke0 of sufentanil in children using the time to peak effect (t peak) method.Shorter measured sufentanil t peak by heart rate compared to blood pressure indicate that the heart rate decrease faster than decreasing of blood pressure.Moreover, the calculated sufentanil ke0 in children depends on the pharmacodynamics parameters.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Korea.

ABSTRACT

Objectives: Although targeting the effect site concentration may offer advantages over the traditional forms of administering intravenous anesthetics, it is not applicable for sufentanil in children because its plasma effect site equilibration rate constant (ke0) is not known yet. We estimated ke0 of sufentanil in children using the time to peak effect (t peak) method.

Materials and methods: Under general anesthesia, sufentanil t peak was measured after administration of a submaximal bolus dose by means of the decrease in heart rate, blood pressure and calculated approximate entropy (ApEn) of electroencephalogram in 105 children (age range: 3-11 years). ke0 was estimated using t peak and known sufentanil pharmacokinetic parameters in normal children.

Results: The mean t peaks were measured as 44 ± 22 s and 227 ± 91 s by heart rate and by mean blood pressure respectively. The estimated ke0 were 5.16/min and 0.49/min by heart rate and blood pressure respectively. t peak could not be measured using the ApEn, thus ke0 could not be calculated by ApEn in children.

Conclusions: Shorter measured sufentanil t peak by heart rate compared to blood pressure indicate that the heart rate decrease faster than decreasing of blood pressure. Moreover, the calculated sufentanil ke0 in children depends on the pharmacodynamics parameters.

No MeSH data available.


Simulation of plasma concentration of sufentanil (Cp) and effect site concentration of sufentanil (Ce). The time to peak effect of heart rate or mean blood pressure was well-matched when Cp equals Ce
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Figure 3: Simulation of plasma concentration of sufentanil (Cp) and effect site concentration of sufentanil (Ce). The time to peak effect of heart rate or mean blood pressure was well-matched when Cp equals Ce

Mentions: Figure 3 shows the simulation of estimated plasma or Ce of sufentanil in two children along with changes of heart rate and blood pressure after the submaximal dose of sufentatnil administration. It demonstrates that the calculated ke0 was well matched with the measured time to peak.


Estimation of the plasma effect site equilibration rate constant of sufentanil in children using the time to peak effect of heart rate and blood pressure.

Song IK, Lee JH, Jung S, Kim JT, Kim HS - Indian J Pharmacol (2015 Jul-Aug)

Simulation of plasma concentration of sufentanil (Cp) and effect site concentration of sufentanil (Ce). The time to peak effect of heart rate or mean blood pressure was well-matched when Cp equals Ce
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4527054&req=5

Figure 3: Simulation of plasma concentration of sufentanil (Cp) and effect site concentration of sufentanil (Ce). The time to peak effect of heart rate or mean blood pressure was well-matched when Cp equals Ce
Mentions: Figure 3 shows the simulation of estimated plasma or Ce of sufentanil in two children along with changes of heart rate and blood pressure after the submaximal dose of sufentatnil administration. It demonstrates that the calculated ke0 was well matched with the measured time to peak.

Bottom Line: We estimated ke0 of sufentanil in children using the time to peak effect (t peak) method.Shorter measured sufentanil t peak by heart rate compared to blood pressure indicate that the heart rate decrease faster than decreasing of blood pressure.Moreover, the calculated sufentanil ke0 in children depends on the pharmacodynamics parameters.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Korea.

ABSTRACT

Objectives: Although targeting the effect site concentration may offer advantages over the traditional forms of administering intravenous anesthetics, it is not applicable for sufentanil in children because its plasma effect site equilibration rate constant (ke0) is not known yet. We estimated ke0 of sufentanil in children using the time to peak effect (t peak) method.

Materials and methods: Under general anesthesia, sufentanil t peak was measured after administration of a submaximal bolus dose by means of the decrease in heart rate, blood pressure and calculated approximate entropy (ApEn) of electroencephalogram in 105 children (age range: 3-11 years). ke0 was estimated using t peak and known sufentanil pharmacokinetic parameters in normal children.

Results: The mean t peaks were measured as 44 ± 22 s and 227 ± 91 s by heart rate and by mean blood pressure respectively. The estimated ke0 were 5.16/min and 0.49/min by heart rate and blood pressure respectively. t peak could not be measured using the ApEn, thus ke0 could not be calculated by ApEn in children.

Conclusions: Shorter measured sufentanil t peak by heart rate compared to blood pressure indicate that the heart rate decrease faster than decreasing of blood pressure. Moreover, the calculated sufentanil ke0 in children depends on the pharmacodynamics parameters.

No MeSH data available.