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Estimation of the plasma effect site equilibration rate constant of sufentanil in children using the time to peak effect of heart rate and blood pressure.

Song IK, Lee JH, Jung S, Kim JT, Kim HS - Indian J Pharmacol (2015 Jul-Aug)

Bottom Line: We estimated ke0 of sufentanil in children using the time to peak effect (t peak) method.Shorter measured sufentanil t peak by heart rate compared to blood pressure indicate that the heart rate decrease faster than decreasing of blood pressure.Moreover, the calculated sufentanil ke0 in children depends on the pharmacodynamics parameters.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Korea.

ABSTRACT

Objectives: Although targeting the effect site concentration may offer advantages over the traditional forms of administering intravenous anesthetics, it is not applicable for sufentanil in children because its plasma effect site equilibration rate constant (ke0) is not known yet. We estimated ke0 of sufentanil in children using the time to peak effect (t peak) method.

Materials and methods: Under general anesthesia, sufentanil t peak was measured after administration of a submaximal bolus dose by means of the decrease in heart rate, blood pressure and calculated approximate entropy (ApEn) of electroencephalogram in 105 children (age range: 3-11 years). ke0 was estimated using t peak and known sufentanil pharmacokinetic parameters in normal children.

Results: The mean t peaks were measured as 44 ± 22 s and 227 ± 91 s by heart rate and by mean blood pressure respectively. The estimated ke0 were 5.16/min and 0.49/min by heart rate and blood pressure respectively. t peak could not be measured using the ApEn, thus ke0 could not be calculated by ApEn in children.

Conclusions: Shorter measured sufentanil t peak by heart rate compared to blood pressure indicate that the heart rate decrease faster than decreasing of blood pressure. Moreover, the calculated sufentanil ke0 in children depends on the pharmacodynamics parameters.

No MeSH data available.


Changes in mean blood pressure after administration of 0.8 mcg/kg of sufentanil. The blood pressure decreased maximally in 220 s after injection of sufentanil. The blood pressure was measured in 1-min intervals
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Figure 2: Changes in mean blood pressure after administration of 0.8 mcg/kg of sufentanil. The blood pressure decreased maximally in 220 s after injection of sufentanil. The blood pressure was measured in 1-min intervals

Mentions: Figure 2 shows the changes in mean blood pressure. Blood pressure was measured at 1-min intervals. The average time to maximal decreased blood pressure was 3 min and 47 s. The estimated ke0 was 0.49/min [Table 2]. This is later than heart rate measurements.


Estimation of the plasma effect site equilibration rate constant of sufentanil in children using the time to peak effect of heart rate and blood pressure.

Song IK, Lee JH, Jung S, Kim JT, Kim HS - Indian J Pharmacol (2015 Jul-Aug)

Changes in mean blood pressure after administration of 0.8 mcg/kg of sufentanil. The blood pressure decreased maximally in 220 s after injection of sufentanil. The blood pressure was measured in 1-min intervals
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4527054&req=5

Figure 2: Changes in mean blood pressure after administration of 0.8 mcg/kg of sufentanil. The blood pressure decreased maximally in 220 s after injection of sufentanil. The blood pressure was measured in 1-min intervals
Mentions: Figure 2 shows the changes in mean blood pressure. Blood pressure was measured at 1-min intervals. The average time to maximal decreased blood pressure was 3 min and 47 s. The estimated ke0 was 0.49/min [Table 2]. This is later than heart rate measurements.

Bottom Line: We estimated ke0 of sufentanil in children using the time to peak effect (t peak) method.Shorter measured sufentanil t peak by heart rate compared to blood pressure indicate that the heart rate decrease faster than decreasing of blood pressure.Moreover, the calculated sufentanil ke0 in children depends on the pharmacodynamics parameters.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Korea.

ABSTRACT

Objectives: Although targeting the effect site concentration may offer advantages over the traditional forms of administering intravenous anesthetics, it is not applicable for sufentanil in children because its plasma effect site equilibration rate constant (ke0) is not known yet. We estimated ke0 of sufentanil in children using the time to peak effect (t peak) method.

Materials and methods: Under general anesthesia, sufentanil t peak was measured after administration of a submaximal bolus dose by means of the decrease in heart rate, blood pressure and calculated approximate entropy (ApEn) of electroencephalogram in 105 children (age range: 3-11 years). ke0 was estimated using t peak and known sufentanil pharmacokinetic parameters in normal children.

Results: The mean t peaks were measured as 44 ± 22 s and 227 ± 91 s by heart rate and by mean blood pressure respectively. The estimated ke0 were 5.16/min and 0.49/min by heart rate and blood pressure respectively. t peak could not be measured using the ApEn, thus ke0 could not be calculated by ApEn in children.

Conclusions: Shorter measured sufentanil t peak by heart rate compared to blood pressure indicate that the heart rate decrease faster than decreasing of blood pressure. Moreover, the calculated sufentanil ke0 in children depends on the pharmacodynamics parameters.

No MeSH data available.