Mathematical modelling of WOX5- and CLE40-mediated columella stem cell homeostasis in Arabidopsis.
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We have also found that WOX5 contributes to, but is not absolutely necessary for, CSC maintenance.Furthermore, our modelling led us to postulate an additional signalling molecule that promotes CSC maintenance.We propose that this WOX5-independent signal originates in the QC, is targeted by CLE40 signalling and is capable of maintaining CSCs.
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Affiliation: Institute of Developmental Genetics, Heinrich Heine University, 40225 DÃ¼sseldorf, Germany.
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Mentions: To determine if the single-cell model implemented in several cells could describe experimental results, a modified version of the model was implemented in a virtual cell column, with the most proximal cell defined as the W-producing QC cell and the rest allowed to take on either CSC or CC fate. The fate of each cell would still depend on W via FCC as in the single-cell model. With this C/W multi-cell model, W and C could diffuse through the cells, emulating inter-cellular communication. The value of C at the QC determines the production rate of W. The network diagram for the C/W multi-cell model is shown in Fig. 5. We also implemented an alternative model (Supplementary File S1), where values of C at each cell decreased the mobility of WOX5 through that cell, and the results of the alternative model matched the results of the C/W multi-cell model distal to the QC. The alternative C/W multi-cell model, where C regulates W mobility rather than production, is described by the following equations, where the BW term in equation 11 (shown in Fig. 8) only applies in the QC (cell i=1). The equation for FCC,i is identical to equation 7 shown in Fig. 5. |
View Article: PubMed Central - PubMed
Affiliation: Institute of Developmental Genetics, Heinrich Heine University, 40225 DÃ¼sseldorf, Germany.
No MeSH data available.