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Mathematical modelling of WOX5- and CLE40-mediated columella stem cell homeostasis in Arabidopsis.

Richards S, Wink RH, Simon R - J. Exp. Bot. (2015)

Bottom Line: We have also found that WOX5 contributes to, but is not absolutely necessary for, CSC maintenance.Furthermore, our modelling led us to postulate an additional signalling molecule that promotes CSC maintenance.We propose that this WOX5-independent signal originates in the QC, is targeted by CLE40 signalling and is capable of maintaining CSCs.

View Article: PubMed Central - PubMed

Affiliation: Institute of Developmental Genetics, Heinrich Heine University, 40225 Düsseldorf, Germany.

No MeSH data available.


Representation of C/W multi-cell model predictions of CSC fate and W and C localization. The number of expected CSC rows, based on experimental results is shown in parentheses. The model is capable of emulating the results of root phenotypes of wild-type roots, wox5 mutant roots cle40 mutant roots, roots with additional synthetic CLE40 (CLE40p) added, and roots expressing WOX5 in all cells through constitutively expressed WOX5 with inducible WOX5 function (iWOX5). Results of a wox5/cle40 double mutant phenotype were also predicted so that the model could be tested later for predictive ability.
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Figure 6: Representation of C/W multi-cell model predictions of CSC fate and W and C localization. The number of expected CSC rows, based on experimental results is shown in parentheses. The model is capable of emulating the results of root phenotypes of wild-type roots, wox5 mutant roots cle40 mutant roots, roots with additional synthetic CLE40 (CLE40p) added, and roots expressing WOX5 in all cells through constitutively expressed WOX5 with inducible WOX5 function (iWOX5). Results of a wox5/cle40 double mutant phenotype were also predicted so that the model could be tested later for predictive ability.

Mentions: C/W multi-cell model predictions are shown in Fig. 6. It was possible to find a range of parameter values that emulated the most common phenotypes of wild type, wox5 and cle40 mutants, WOX5 constitutive expression, and addition of CLE40p to wild type.


Mathematical modelling of WOX5- and CLE40-mediated columella stem cell homeostasis in Arabidopsis.

Richards S, Wink RH, Simon R - J. Exp. Bot. (2015)

Representation of C/W multi-cell model predictions of CSC fate and W and C localization. The number of expected CSC rows, based on experimental results is shown in parentheses. The model is capable of emulating the results of root phenotypes of wild-type roots, wox5 mutant roots cle40 mutant roots, roots with additional synthetic CLE40 (CLE40p) added, and roots expressing WOX5 in all cells through constitutively expressed WOX5 with inducible WOX5 function (iWOX5). Results of a wox5/cle40 double mutant phenotype were also predicted so that the model could be tested later for predictive ability.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4526915&req=5

Figure 6: Representation of C/W multi-cell model predictions of CSC fate and W and C localization. The number of expected CSC rows, based on experimental results is shown in parentheses. The model is capable of emulating the results of root phenotypes of wild-type roots, wox5 mutant roots cle40 mutant roots, roots with additional synthetic CLE40 (CLE40p) added, and roots expressing WOX5 in all cells through constitutively expressed WOX5 with inducible WOX5 function (iWOX5). Results of a wox5/cle40 double mutant phenotype were also predicted so that the model could be tested later for predictive ability.
Mentions: C/W multi-cell model predictions are shown in Fig. 6. It was possible to find a range of parameter values that emulated the most common phenotypes of wild type, wox5 and cle40 mutants, WOX5 constitutive expression, and addition of CLE40p to wild type.

Bottom Line: We have also found that WOX5 contributes to, but is not absolutely necessary for, CSC maintenance.Furthermore, our modelling led us to postulate an additional signalling molecule that promotes CSC maintenance.We propose that this WOX5-independent signal originates in the QC, is targeted by CLE40 signalling and is capable of maintaining CSCs.

View Article: PubMed Central - PubMed

Affiliation: Institute of Developmental Genetics, Heinrich Heine University, 40225 Düsseldorf, Germany.

No MeSH data available.