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Mathematical modelling of WOX5- and CLE40-mediated columella stem cell homeostasis in Arabidopsis.

Richards S, Wink RH, Simon R - J. Exp. Bot. (2015)

Bottom Line: We have also found that WOX5 contributes to, but is not absolutely necessary for, CSC maintenance.Furthermore, our modelling led us to postulate an additional signalling molecule that promotes CSC maintenance.We propose that this WOX5-independent signal originates in the QC, is targeted by CLE40 signalling and is capable of maintaining CSCs.

View Article: PubMed Central - PubMed

Affiliation: Institute of Developmental Genetics, Heinrich Heine University, 40225 Düsseldorf, Germany.

No MeSH data available.


Related in: MedlinePlus

Graphical and mathematical presentation of the relationships between C, W, FCC and FQC. Equations (1) and (2) determine the rate changes of W and C values, respectively, while equations (3) and (4) detail the Hill functions governing cell fate dependence on W. C inhibits W (green), while W promotes production of FQC (yellow) and represses FCC (orange). FQC provides positive feedback to W (blue), and FCC promotes C (teal). W and C are degraded at a constant rate (grey). Bw, Kcw, aw, Bc, ac, Wa, Wb, m and n are parameters.
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Figure 3: Graphical and mathematical presentation of the relationships between C, W, FCC and FQC. Equations (1) and (2) determine the rate changes of W and C values, respectively, while equations (3) and (4) detail the Hill functions governing cell fate dependence on W. C inhibits W (green), while W promotes production of FQC (yellow) and represses FCC (orange). FQC provides positive feedback to W (blue), and FCC promotes C (teal). W and C are degraded at a constant rate (grey). Bw, Kcw, aw, Bc, ac, Wa, Wb, m and n are parameters.

Mentions: FQC as the representative of QC fate determines the production rate of W. To simulate production of W only in QC cells, the W production rate increases as FQC increases (blue in Figs 3 and 4). Likewise, FCC determines the production rate of C. The production rate of C increases as FCC increases to simulate CLE40 being produced only in CCs (teal in Figs 3 and 4). A network diagram of the interactions is shown in Fig. 3 with the corresponding equations.


Mathematical modelling of WOX5- and CLE40-mediated columella stem cell homeostasis in Arabidopsis.

Richards S, Wink RH, Simon R - J. Exp. Bot. (2015)

Graphical and mathematical presentation of the relationships between C, W, FCC and FQC. Equations (1) and (2) determine the rate changes of W and C values, respectively, while equations (3) and (4) detail the Hill functions governing cell fate dependence on W. C inhibits W (green), while W promotes production of FQC (yellow) and represses FCC (orange). FQC provides positive feedback to W (blue), and FCC promotes C (teal). W and C are degraded at a constant rate (grey). Bw, Kcw, aw, Bc, ac, Wa, Wb, m and n are parameters.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4526915&req=5

Figure 3: Graphical and mathematical presentation of the relationships between C, W, FCC and FQC. Equations (1) and (2) determine the rate changes of W and C values, respectively, while equations (3) and (4) detail the Hill functions governing cell fate dependence on W. C inhibits W (green), while W promotes production of FQC (yellow) and represses FCC (orange). FQC provides positive feedback to W (blue), and FCC promotes C (teal). W and C are degraded at a constant rate (grey). Bw, Kcw, aw, Bc, ac, Wa, Wb, m and n are parameters.
Mentions: FQC as the representative of QC fate determines the production rate of W. To simulate production of W only in QC cells, the W production rate increases as FQC increases (blue in Figs 3 and 4). Likewise, FCC determines the production rate of C. The production rate of C increases as FCC increases to simulate CLE40 being produced only in CCs (teal in Figs 3 and 4). A network diagram of the interactions is shown in Fig. 3 with the corresponding equations.

Bottom Line: We have also found that WOX5 contributes to, but is not absolutely necessary for, CSC maintenance.Furthermore, our modelling led us to postulate an additional signalling molecule that promotes CSC maintenance.We propose that this WOX5-independent signal originates in the QC, is targeted by CLE40 signalling and is capable of maintaining CSCs.

View Article: PubMed Central - PubMed

Affiliation: Institute of Developmental Genetics, Heinrich Heine University, 40225 Düsseldorf, Germany.

No MeSH data available.


Related in: MedlinePlus