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Low copulatory activity in selectively bred Sardinian alcohol-nonpreferring (sNP) relative to alcohol-preferring (sP) rats.

Karlsson O, Colombo G, Roman E - Ups. J. Med. Sci. (2015)

Bottom Line: There is a growing consensus that similar neural mechanisms are involved in the reinforcing properties of natural rewards, like food and sex, and drugs of abuse.Rat lines selectively bred for high and low oral alcohol intake and preference have been useful for understanding factors contributing to excessive alcohol intake and may constitute proper animal models for investigating the neurobiological basis of natural rewarding stimuli.Only minor differences between sP and Wistar rats were revealed.

View Article: PubMed Central - PubMed

Affiliation: Center for Molecular Medicine, Department of Clinical Neuroscience, Karolinska Institute , K8, 171 76 Stockholm , Sweden.

ABSTRACT

Background: There is a growing consensus that similar neural mechanisms are involved in the reinforcing properties of natural rewards, like food and sex, and drugs of abuse. Rat lines selectively bred for high and low oral alcohol intake and preference have been useful for understanding factors contributing to excessive alcohol intake and may constitute proper animal models for investigating the neurobiological basis of natural rewarding stimuli.

Methods: The present study evaluated copulatory behavior in alcohol and sexually naïve Sardinian alcohol-preferring (sP) and -nonpreferring (sNP) male rats in three consecutive copulatory behavior tests.

Results: The main finding was that, under the conditions used in this study, sNP rats were sexually inactive relative to sP rats. To gain more information about the sexual behavior in sP rats, Wistar rats were included as an external reference strain. Only minor differences between sP and Wistar rats were revealed.

Conclusions: The reason behind the low copulatory activity of sNP rats remains to be elucidated, but may in part be mediated by innate differences in brain transmitter systems. The comparison between sP and Wistar rats may also suggest that the inherent proclivity to excessive alcohol drinking in sP rats may mainly be dependent on its anxiolytic properties, as previously proposed, and not changes in the reward system.

No MeSH data available.


Related in: MedlinePlus

The number of mounts (A), intromissions (B), and sum of mounts and intromissions (C) in the three copulatory behavior tests in male sP (n = 15) and Wistar (n = 10) rats. Values represent individual data points with the median value marked as a line. # p < 0.05 compared to the first copulatory behavior test within the respective group (Wilcoxon signed rank test).
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Figure 3: The number of mounts (A), intromissions (B), and sum of mounts and intromissions (C) in the three copulatory behavior tests in male sP (n = 15) and Wistar (n = 10) rats. Values represent individual data points with the median value marked as a line. # p < 0.05 compared to the first copulatory behavior test within the respective group (Wilcoxon signed rank test).

Mentions: The number of intromissions was higher (Z = 2.24, p < 0.05) in the third test relative to the first test in Wistar rats, with a trend close to statistical significance also for sP rats (Z = 1.91, p = 0.056) (Figure 3). The sum of mounts and intromissions was higher (Z = 2.40, p < 0.05) in the third test compared with the first test in Wistar rats, while no such difference was found in sP rats.


Low copulatory activity in selectively bred Sardinian alcohol-nonpreferring (sNP) relative to alcohol-preferring (sP) rats.

Karlsson O, Colombo G, Roman E - Ups. J. Med. Sci. (2015)

The number of mounts (A), intromissions (B), and sum of mounts and intromissions (C) in the three copulatory behavior tests in male sP (n = 15) and Wistar (n = 10) rats. Values represent individual data points with the median value marked as a line. # p < 0.05 compared to the first copulatory behavior test within the respective group (Wilcoxon signed rank test).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4526873&req=5

Figure 3: The number of mounts (A), intromissions (B), and sum of mounts and intromissions (C) in the three copulatory behavior tests in male sP (n = 15) and Wistar (n = 10) rats. Values represent individual data points with the median value marked as a line. # p < 0.05 compared to the first copulatory behavior test within the respective group (Wilcoxon signed rank test).
Mentions: The number of intromissions was higher (Z = 2.24, p < 0.05) in the third test relative to the first test in Wistar rats, with a trend close to statistical significance also for sP rats (Z = 1.91, p = 0.056) (Figure 3). The sum of mounts and intromissions was higher (Z = 2.40, p < 0.05) in the third test compared with the first test in Wistar rats, while no such difference was found in sP rats.

Bottom Line: There is a growing consensus that similar neural mechanisms are involved in the reinforcing properties of natural rewards, like food and sex, and drugs of abuse.Rat lines selectively bred for high and low oral alcohol intake and preference have been useful for understanding factors contributing to excessive alcohol intake and may constitute proper animal models for investigating the neurobiological basis of natural rewarding stimuli.Only minor differences between sP and Wistar rats were revealed.

View Article: PubMed Central - PubMed

Affiliation: Center for Molecular Medicine, Department of Clinical Neuroscience, Karolinska Institute , K8, 171 76 Stockholm , Sweden.

ABSTRACT

Background: There is a growing consensus that similar neural mechanisms are involved in the reinforcing properties of natural rewards, like food and sex, and drugs of abuse. Rat lines selectively bred for high and low oral alcohol intake and preference have been useful for understanding factors contributing to excessive alcohol intake and may constitute proper animal models for investigating the neurobiological basis of natural rewarding stimuli.

Methods: The present study evaluated copulatory behavior in alcohol and sexually naïve Sardinian alcohol-preferring (sP) and -nonpreferring (sNP) male rats in three consecutive copulatory behavior tests.

Results: The main finding was that, under the conditions used in this study, sNP rats were sexually inactive relative to sP rats. To gain more information about the sexual behavior in sP rats, Wistar rats were included as an external reference strain. Only minor differences between sP and Wistar rats were revealed.

Conclusions: The reason behind the low copulatory activity of sNP rats remains to be elucidated, but may in part be mediated by innate differences in brain transmitter systems. The comparison between sP and Wistar rats may also suggest that the inherent proclivity to excessive alcohol drinking in sP rats may mainly be dependent on its anxiolytic properties, as previously proposed, and not changes in the reward system.

No MeSH data available.


Related in: MedlinePlus