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Low copulatory activity in selectively bred Sardinian alcohol-nonpreferring (sNP) relative to alcohol-preferring (sP) rats.

Karlsson O, Colombo G, Roman E - Ups. J. Med. Sci. (2015)

Bottom Line: There is a growing consensus that similar neural mechanisms are involved in the reinforcing properties of natural rewards, like food and sex, and drugs of abuse.Rat lines selectively bred for high and low oral alcohol intake and preference have been useful for understanding factors contributing to excessive alcohol intake and may constitute proper animal models for investigating the neurobiological basis of natural rewarding stimuli.Only minor differences between sP and Wistar rats were revealed.

View Article: PubMed Central - PubMed

Affiliation: Center for Molecular Medicine, Department of Clinical Neuroscience, Karolinska Institute , K8, 171 76 Stockholm , Sweden.

ABSTRACT

Background: There is a growing consensus that similar neural mechanisms are involved in the reinforcing properties of natural rewards, like food and sex, and drugs of abuse. Rat lines selectively bred for high and low oral alcohol intake and preference have been useful for understanding factors contributing to excessive alcohol intake and may constitute proper animal models for investigating the neurobiological basis of natural rewarding stimuli.

Methods: The present study evaluated copulatory behavior in alcohol and sexually naïve Sardinian alcohol-preferring (sP) and -nonpreferring (sNP) male rats in three consecutive copulatory behavior tests.

Results: The main finding was that, under the conditions used in this study, sNP rats were sexually inactive relative to sP rats. To gain more information about the sexual behavior in sP rats, Wistar rats were included as an external reference strain. Only minor differences between sP and Wistar rats were revealed.

Conclusions: The reason behind the low copulatory activity of sNP rats remains to be elucidated, but may in part be mediated by innate differences in brain transmitter systems. The comparison between sP and Wistar rats may also suggest that the inherent proclivity to excessive alcohol drinking in sP rats may mainly be dependent on its anxiolytic properties, as previously proposed, and not changes in the reward system.

No MeSH data available.


Related in: MedlinePlus

The percentage number of sNP (n = 15) and sP (n = 15) rats mounting (A), intromitting (B), and achieving ejaculation (C) over the three copulatory behavior tests. Due to the low number of sNP rats engaging in copulatory activity also in the third test, they were excluded from further detailed statistical analyses of copulatory behavior. Wistar (n = 10) rats were included as a reference strain. **p < 0.01, *** p < 0.001, **** p < 0.0001 compared to sP rats (chi-square test).
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Figure 1: The percentage number of sNP (n = 15) and sP (n = 15) rats mounting (A), intromitting (B), and achieving ejaculation (C) over the three copulatory behavior tests. Due to the low number of sNP rats engaging in copulatory activity also in the third test, they were excluded from further detailed statistical analyses of copulatory behavior. Wistar (n = 10) rats were included as a reference strain. **p < 0.01, *** p < 0.001, **** p < 0.0001 compared to sP rats (chi-square test).

Mentions: The main finding in the present study is a very low copulatory activity in male sNP rats (Figure 1). Thus, fewer sNP than sP rats engaged in copulatory behavior in all three tests. In the first and second test, only 2 out of 15 sNP males mounted, and in the third test this number was increased to 3 males, which was significantly fewer (chi-square = 8.89, df = 1, p < 0.01; chi-square = 13.39, df = 1, p < 0.001; chi-square = 13.39, df = 1, p < 0.001, respectively) when compared with sP rats. In the second and third test, no sNP rats achieved intromission (chi-square = 9.13, df = 1, p < 0.01; chi-square = 17.37, df = 1, p < 0.0001) or ejaculation (chi-square = 10.91, df = 1, p < 0.001). Based on this sexual inactivity, sNP rats were excluded from further detailed comparison with the sP line. To get information about the copulatory behavior in sP rats, a detailed statistical analysis using Wistar rats as reference strain was performed.


Low copulatory activity in selectively bred Sardinian alcohol-nonpreferring (sNP) relative to alcohol-preferring (sP) rats.

Karlsson O, Colombo G, Roman E - Ups. J. Med. Sci. (2015)

The percentage number of sNP (n = 15) and sP (n = 15) rats mounting (A), intromitting (B), and achieving ejaculation (C) over the three copulatory behavior tests. Due to the low number of sNP rats engaging in copulatory activity also in the third test, they were excluded from further detailed statistical analyses of copulatory behavior. Wistar (n = 10) rats were included as a reference strain. **p < 0.01, *** p < 0.001, **** p < 0.0001 compared to sP rats (chi-square test).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4526873&req=5

Figure 1: The percentage number of sNP (n = 15) and sP (n = 15) rats mounting (A), intromitting (B), and achieving ejaculation (C) over the three copulatory behavior tests. Due to the low number of sNP rats engaging in copulatory activity also in the third test, they were excluded from further detailed statistical analyses of copulatory behavior. Wistar (n = 10) rats were included as a reference strain. **p < 0.01, *** p < 0.001, **** p < 0.0001 compared to sP rats (chi-square test).
Mentions: The main finding in the present study is a very low copulatory activity in male sNP rats (Figure 1). Thus, fewer sNP than sP rats engaged in copulatory behavior in all three tests. In the first and second test, only 2 out of 15 sNP males mounted, and in the third test this number was increased to 3 males, which was significantly fewer (chi-square = 8.89, df = 1, p < 0.01; chi-square = 13.39, df = 1, p < 0.001; chi-square = 13.39, df = 1, p < 0.001, respectively) when compared with sP rats. In the second and third test, no sNP rats achieved intromission (chi-square = 9.13, df = 1, p < 0.01; chi-square = 17.37, df = 1, p < 0.0001) or ejaculation (chi-square = 10.91, df = 1, p < 0.001). Based on this sexual inactivity, sNP rats were excluded from further detailed comparison with the sP line. To get information about the copulatory behavior in sP rats, a detailed statistical analysis using Wistar rats as reference strain was performed.

Bottom Line: There is a growing consensus that similar neural mechanisms are involved in the reinforcing properties of natural rewards, like food and sex, and drugs of abuse.Rat lines selectively bred for high and low oral alcohol intake and preference have been useful for understanding factors contributing to excessive alcohol intake and may constitute proper animal models for investigating the neurobiological basis of natural rewarding stimuli.Only minor differences between sP and Wistar rats were revealed.

View Article: PubMed Central - PubMed

Affiliation: Center for Molecular Medicine, Department of Clinical Neuroscience, Karolinska Institute , K8, 171 76 Stockholm , Sweden.

ABSTRACT

Background: There is a growing consensus that similar neural mechanisms are involved in the reinforcing properties of natural rewards, like food and sex, and drugs of abuse. Rat lines selectively bred for high and low oral alcohol intake and preference have been useful for understanding factors contributing to excessive alcohol intake and may constitute proper animal models for investigating the neurobiological basis of natural rewarding stimuli.

Methods: The present study evaluated copulatory behavior in alcohol and sexually naïve Sardinian alcohol-preferring (sP) and -nonpreferring (sNP) male rats in three consecutive copulatory behavior tests.

Results: The main finding was that, under the conditions used in this study, sNP rats were sexually inactive relative to sP rats. To gain more information about the sexual behavior in sP rats, Wistar rats were included as an external reference strain. Only minor differences between sP and Wistar rats were revealed.

Conclusions: The reason behind the low copulatory activity of sNP rats remains to be elucidated, but may in part be mediated by innate differences in brain transmitter systems. The comparison between sP and Wistar rats may also suggest that the inherent proclivity to excessive alcohol drinking in sP rats may mainly be dependent on its anxiolytic properties, as previously proposed, and not changes in the reward system.

No MeSH data available.


Related in: MedlinePlus