Limits...
Vascular permeability--the essentials.

Claesson-Welsh L - Ups. J. Med. Sci. (2015)

Bottom Line: This may result in excessive formation of new, unstable, and hyperpermeable vessels with poor blood flow, which further promotes hypoxia and disease propagation.Thus, there is a strong incentive to learn more about an important aspect of vessel biology in health and disease: the regulation of vessel permeability.The current review aims to summarize current insights into different mechanisms of vascular permeability, its regulatory factors, and the consequences for disease.

View Article: PubMed Central - PubMed

Affiliation: Uppsala University, Department of Immunology, Genetics and Pathology, Rudbeck Laboratory , Uppsala , Sweden.

ABSTRACT
The vasculature, composed of vessels of different morphology and function, distributes blood to all tissues and maintains physiological tissue homeostasis. In pathologies, the vasculature is often affected by, and engaged in, the disease process. This may result in excessive formation of new, unstable, and hyperpermeable vessels with poor blood flow, which further promotes hypoxia and disease propagation. Chronic vessel permeability may also facilitate metastatic spread of cancer. Thus, there is a strong incentive to learn more about an important aspect of vessel biology in health and disease: the regulation of vessel permeability. The current review aims to summarize current insights into different mechanisms of vascular permeability, its regulatory factors, and the consequences for disease.

No MeSH data available.


Related in: MedlinePlus

Signal transduction regulating opening of adherens junctions. Three main pathways are depicted: 1) VEGF-induced activation of c-Src leading to VE-cadherin (VE-cad) hyperphosphorylation (pY); 2) activation of eNOS leading to NO generation and effects on adherens junctions; and 3) activation of small GTPases such as RAC followed by rearrangement of the actin cytoskeleton and cell retraction. For details, see text.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4526869&req=5

Figure 3: Signal transduction regulating opening of adherens junctions. Three main pathways are depicted: 1) VEGF-induced activation of c-Src leading to VE-cadherin (VE-cad) hyperphosphorylation (pY); 2) activation of eNOS leading to NO generation and effects on adherens junctions; and 3) activation of small GTPases such as RAC followed by rearrangement of the actin cytoskeleton and cell retraction. For details, see text.

Mentions: The eNOS-NO pathway is implicated also in VEGF-regulated vascular permeability since ablation of eNOS expression blocks the VEGF response (51). Figure 3 depicts a schematic summary of signal transduction pathways regulating disassembly of adherens junctions.


Vascular permeability--the essentials.

Claesson-Welsh L - Ups. J. Med. Sci. (2015)

Signal transduction regulating opening of adherens junctions. Three main pathways are depicted: 1) VEGF-induced activation of c-Src leading to VE-cadherin (VE-cad) hyperphosphorylation (pY); 2) activation of eNOS leading to NO generation and effects on adherens junctions; and 3) activation of small GTPases such as RAC followed by rearrangement of the actin cytoskeleton and cell retraction. For details, see text.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4526869&req=5

Figure 3: Signal transduction regulating opening of adherens junctions. Three main pathways are depicted: 1) VEGF-induced activation of c-Src leading to VE-cadherin (VE-cad) hyperphosphorylation (pY); 2) activation of eNOS leading to NO generation and effects on adherens junctions; and 3) activation of small GTPases such as RAC followed by rearrangement of the actin cytoskeleton and cell retraction. For details, see text.
Mentions: The eNOS-NO pathway is implicated also in VEGF-regulated vascular permeability since ablation of eNOS expression blocks the VEGF response (51). Figure 3 depicts a schematic summary of signal transduction pathways regulating disassembly of adherens junctions.

Bottom Line: This may result in excessive formation of new, unstable, and hyperpermeable vessels with poor blood flow, which further promotes hypoxia and disease propagation.Thus, there is a strong incentive to learn more about an important aspect of vessel biology in health and disease: the regulation of vessel permeability.The current review aims to summarize current insights into different mechanisms of vascular permeability, its regulatory factors, and the consequences for disease.

View Article: PubMed Central - PubMed

Affiliation: Uppsala University, Department of Immunology, Genetics and Pathology, Rudbeck Laboratory , Uppsala , Sweden.

ABSTRACT
The vasculature, composed of vessels of different morphology and function, distributes blood to all tissues and maintains physiological tissue homeostasis. In pathologies, the vasculature is often affected by, and engaged in, the disease process. This may result in excessive formation of new, unstable, and hyperpermeable vessels with poor blood flow, which further promotes hypoxia and disease propagation. Chronic vessel permeability may also facilitate metastatic spread of cancer. Thus, there is a strong incentive to learn more about an important aspect of vessel biology in health and disease: the regulation of vessel permeability. The current review aims to summarize current insights into different mechanisms of vascular permeability, its regulatory factors, and the consequences for disease.

No MeSH data available.


Related in: MedlinePlus