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Cerebral Correlates of Abnormal Emotion Conflict Processing in Euthymic Bipolar Patients: A Functional MRI Study.

Favre P, Polosan M, Pichat C, Bougerol T, Baciu M - PLoS ONE (2015)

Bottom Line: Furthermore, BP showed decreased activation of the right dorsolateral prefrontal cortex (DLPFC) during the monitoring and a lack of bilateral amygdala deactivation during the resolution of the emotional conflict.Overall, our results highlighted dysfunctional processing of the emotion conflict in euthymic BP that may be subtended by abnormal activity and connectivity of the DLPFC during the conflict monitoring, which, in turn, leads to failure of amygdala deactivation during the resolution of the conflict.Emotional dysregulation in BP may be underpinned by a lack of top-down cognitive control and a difficulty to focus on the task due to persistent self-oriented attention.

View Article: PubMed Central - PubMed

Affiliation: Univ. Grenoble Alpes, LPNC, CNRS UMR 5105, Grenoble, France.

ABSTRACT

Background: Patients with bipolar disorder experience cognitive and emotional impairment that may persist even during the euthymic state of the disease. These persistent symptoms in bipolar patients (BP) may be characterized by disturbances of emotion regulation and related fronto-limbic brain circuitry. The present study aims to investigate the modulation of fronto-limbic activity and connectivity in BP by the processing of emotional conflict.

Methods: Fourteen euthymic BP and 13 matched healthy subjects (HS) underwent functional magnetic resonance imaging (fMRI) while performing a word-face emotional Stroop task designed to dissociate the monitoring/generation of emotional conflict from its resolution. Functional connectivity was determined by means of psychophysiological interaction (PPI) approach.

Results: Relative to HS, BP were slower to process incongruent stimuli, reflecting higher amount of behavioral interference during emotional Stroop. Furthermore, BP showed decreased activation of the right dorsolateral prefrontal cortex (DLPFC) during the monitoring and a lack of bilateral amygdala deactivation during the resolution of the emotional conflict. In addition, during conflict monitoring, BP showed abnormal positive connectivity between the right DLPFC and several regions of the default mode network.

Conclusions: Overall, our results highlighted dysfunctional processing of the emotion conflict in euthymic BP that may be subtended by abnormal activity and connectivity of the DLPFC during the conflict monitoring, which, in turn, leads to failure of amygdala deactivation during the resolution of the conflict. Emotional dysregulation in BP may be underpinned by a lack of top-down cognitive control and a difficulty to focus on the task due to persistent self-oriented attention.

No MeSH data available.


Related in: MedlinePlus

Psychophysiological interaction results.Panel A: Results provided by “within group” analysis in healthy subjects; Panel B: Results provided by “within group” analysis in bipolar patients; Panel C: Results provided by the “between-group” analysis in Bipolar patients vs. Healthy subjects. Red-scale areas represent regions showing positive connectivity with the right dorsolateral prefrontal cortex; Blue-scale areas represent regions showing negative connectivity with the right dorsolateral prefrontal cortex. Identified regions are projected onto 2D anatomical slices in axial, coronal and sagittal orientations (p < 0.005 uncorrected at whole brain level, pFWE < 0.05 after small volume correction).
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pone.0134961.g005: Psychophysiological interaction results.Panel A: Results provided by “within group” analysis in healthy subjects; Panel B: Results provided by “within group” analysis in bipolar patients; Panel C: Results provided by the “between-group” analysis in Bipolar patients vs. Healthy subjects. Red-scale areas represent regions showing positive connectivity with the right dorsolateral prefrontal cortex; Blue-scale areas represent regions showing negative connectivity with the right dorsolateral prefrontal cortex. Identified regions are projected onto 2D anatomical slices in axial, coronal and sagittal orientations (p < 0.005 uncorrected at whole brain level, pFWE < 0.05 after small volume correction).

Mentions: As the conflict Resolution contrast did not elicited significant results, the PPI analyses were only conducted on the conflict Monitoring contrast. Within-group analysis for HS revealed significant negative connectivity between the right DLPFC and bilateral superior and middle frontal gyri as well as with the right middle temporal gyrus. More interestingly, HS also showed negative connectivity between the right DLPFC and some areas of the DMN, such as the ACC and the left hippocampus (Fig 5A, Table 4). No region showed significant positive connectivity with the right DLPFC in HS. In BP, the analysis revealed significant negative connectivity between the right DLPFC and the left hippocampus solely. Moreover, BP showed positive connectivity between the right DLPFC and three areas of the DMN, i.e., the subgenual ACC (sgACC), the right angular gyrus and a cluster that encompassed the precuneus and the PCC bilaterally (Fig 5B, Table 4).


Cerebral Correlates of Abnormal Emotion Conflict Processing in Euthymic Bipolar Patients: A Functional MRI Study.

Favre P, Polosan M, Pichat C, Bougerol T, Baciu M - PLoS ONE (2015)

Psychophysiological interaction results.Panel A: Results provided by “within group” analysis in healthy subjects; Panel B: Results provided by “within group” analysis in bipolar patients; Panel C: Results provided by the “between-group” analysis in Bipolar patients vs. Healthy subjects. Red-scale areas represent regions showing positive connectivity with the right dorsolateral prefrontal cortex; Blue-scale areas represent regions showing negative connectivity with the right dorsolateral prefrontal cortex. Identified regions are projected onto 2D anatomical slices in axial, coronal and sagittal orientations (p < 0.005 uncorrected at whole brain level, pFWE < 0.05 after small volume correction).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4526683&req=5

pone.0134961.g005: Psychophysiological interaction results.Panel A: Results provided by “within group” analysis in healthy subjects; Panel B: Results provided by “within group” analysis in bipolar patients; Panel C: Results provided by the “between-group” analysis in Bipolar patients vs. Healthy subjects. Red-scale areas represent regions showing positive connectivity with the right dorsolateral prefrontal cortex; Blue-scale areas represent regions showing negative connectivity with the right dorsolateral prefrontal cortex. Identified regions are projected onto 2D anatomical slices in axial, coronal and sagittal orientations (p < 0.005 uncorrected at whole brain level, pFWE < 0.05 after small volume correction).
Mentions: As the conflict Resolution contrast did not elicited significant results, the PPI analyses were only conducted on the conflict Monitoring contrast. Within-group analysis for HS revealed significant negative connectivity between the right DLPFC and bilateral superior and middle frontal gyri as well as with the right middle temporal gyrus. More interestingly, HS also showed negative connectivity between the right DLPFC and some areas of the DMN, such as the ACC and the left hippocampus (Fig 5A, Table 4). No region showed significant positive connectivity with the right DLPFC in HS. In BP, the analysis revealed significant negative connectivity between the right DLPFC and the left hippocampus solely. Moreover, BP showed positive connectivity between the right DLPFC and three areas of the DMN, i.e., the subgenual ACC (sgACC), the right angular gyrus and a cluster that encompassed the precuneus and the PCC bilaterally (Fig 5B, Table 4).

Bottom Line: Furthermore, BP showed decreased activation of the right dorsolateral prefrontal cortex (DLPFC) during the monitoring and a lack of bilateral amygdala deactivation during the resolution of the emotional conflict.Overall, our results highlighted dysfunctional processing of the emotion conflict in euthymic BP that may be subtended by abnormal activity and connectivity of the DLPFC during the conflict monitoring, which, in turn, leads to failure of amygdala deactivation during the resolution of the conflict.Emotional dysregulation in BP may be underpinned by a lack of top-down cognitive control and a difficulty to focus on the task due to persistent self-oriented attention.

View Article: PubMed Central - PubMed

Affiliation: Univ. Grenoble Alpes, LPNC, CNRS UMR 5105, Grenoble, France.

ABSTRACT

Background: Patients with bipolar disorder experience cognitive and emotional impairment that may persist even during the euthymic state of the disease. These persistent symptoms in bipolar patients (BP) may be characterized by disturbances of emotion regulation and related fronto-limbic brain circuitry. The present study aims to investigate the modulation of fronto-limbic activity and connectivity in BP by the processing of emotional conflict.

Methods: Fourteen euthymic BP and 13 matched healthy subjects (HS) underwent functional magnetic resonance imaging (fMRI) while performing a word-face emotional Stroop task designed to dissociate the monitoring/generation of emotional conflict from its resolution. Functional connectivity was determined by means of psychophysiological interaction (PPI) approach.

Results: Relative to HS, BP were slower to process incongruent stimuli, reflecting higher amount of behavioral interference during emotional Stroop. Furthermore, BP showed decreased activation of the right dorsolateral prefrontal cortex (DLPFC) during the monitoring and a lack of bilateral amygdala deactivation during the resolution of the emotional conflict. In addition, during conflict monitoring, BP showed abnormal positive connectivity between the right DLPFC and several regions of the default mode network.

Conclusions: Overall, our results highlighted dysfunctional processing of the emotion conflict in euthymic BP that may be subtended by abnormal activity and connectivity of the DLPFC during the conflict monitoring, which, in turn, leads to failure of amygdala deactivation during the resolution of the conflict. Emotional dysregulation in BP may be underpinned by a lack of top-down cognitive control and a difficulty to focus on the task due to persistent self-oriented attention.

No MeSH data available.


Related in: MedlinePlus