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Cerebral Correlates of Abnormal Emotion Conflict Processing in Euthymic Bipolar Patients: A Functional MRI Study.

Favre P, Polosan M, Pichat C, Bougerol T, Baciu M - PLoS ONE (2015)

Bottom Line: Furthermore, BP showed decreased activation of the right dorsolateral prefrontal cortex (DLPFC) during the monitoring and a lack of bilateral amygdala deactivation during the resolution of the emotional conflict.Overall, our results highlighted dysfunctional processing of the emotion conflict in euthymic BP that may be subtended by abnormal activity and connectivity of the DLPFC during the conflict monitoring, which, in turn, leads to failure of amygdala deactivation during the resolution of the conflict.Emotional dysregulation in BP may be underpinned by a lack of top-down cognitive control and a difficulty to focus on the task due to persistent self-oriented attention.

View Article: PubMed Central - PubMed

Affiliation: Univ. Grenoble Alpes, LPNC, CNRS UMR 5105, Grenoble, France.

ABSTRACT

Background: Patients with bipolar disorder experience cognitive and emotional impairment that may persist even during the euthymic state of the disease. These persistent symptoms in bipolar patients (BP) may be characterized by disturbances of emotion regulation and related fronto-limbic brain circuitry. The present study aims to investigate the modulation of fronto-limbic activity and connectivity in BP by the processing of emotional conflict.

Methods: Fourteen euthymic BP and 13 matched healthy subjects (HS) underwent functional magnetic resonance imaging (fMRI) while performing a word-face emotional Stroop task designed to dissociate the monitoring/generation of emotional conflict from its resolution. Functional connectivity was determined by means of psychophysiological interaction (PPI) approach.

Results: Relative to HS, BP were slower to process incongruent stimuli, reflecting higher amount of behavioral interference during emotional Stroop. Furthermore, BP showed decreased activation of the right dorsolateral prefrontal cortex (DLPFC) during the monitoring and a lack of bilateral amygdala deactivation during the resolution of the emotional conflict. In addition, during conflict monitoring, BP showed abnormal positive connectivity between the right DLPFC and several regions of the default mode network.

Conclusions: Overall, our results highlighted dysfunctional processing of the emotion conflict in euthymic BP that may be subtended by abnormal activity and connectivity of the DLPFC during the conflict monitoring, which, in turn, leads to failure of amygdala deactivation during the resolution of the conflict. Emotional dysregulation in BP may be underpinned by a lack of top-down cognitive control and a difficulty to focus on the task due to persistent self-oriented attention.

No MeSH data available.


Related in: MedlinePlus

Results provided by between-group analyses.Panel A: Whole-brain comparison in HS vs BP during conflict monitoring (LR > HR) (p < 0.001 uncorrected at whole brain level, pFWE < 0.05 after small volume correction). Identified regions are projected onto 2D anatomical slices in axial, coronal and sagittal orientations. Panel B: Region of interest analysis focused on bilateral amygdala. The graph shows the mean %MR signal intensity variations ± SE according to the group and the amount of the conflict (LR vs HR). *p<0.05. Abbreviations: BP: Bipolar patients; HS: Healthy subjects; LR: Low conflict resolution; HR: High conflict resolution.
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pone.0134961.g004: Results provided by between-group analyses.Panel A: Whole-brain comparison in HS vs BP during conflict monitoring (LR > HR) (p < 0.001 uncorrected at whole brain level, pFWE < 0.05 after small volume correction). Identified regions are projected onto 2D anatomical slices in axial, coronal and sagittal orientations. Panel B: Region of interest analysis focused on bilateral amygdala. The graph shows the mean %MR signal intensity variations ± SE according to the group and the amount of the conflict (LR vs HR). *p<0.05. Abbreviations: BP: Bipolar patients; HS: Healthy subjects; LR: Low conflict resolution; HR: High conflict resolution.

Mentions: The conflict Monitoring contrast revealed stronger activation in HS in comparison to BP in frontal regions including the right middle (dorsolateral part) and superior frontal gyri, as well as in the left middle temporal and left supramarginal gyri (Fig 4A, Table 3). No regions were significantly more activated in BP compared to HS. The conflict Resolution contrast did not reveal significant differences between groups.


Cerebral Correlates of Abnormal Emotion Conflict Processing in Euthymic Bipolar Patients: A Functional MRI Study.

Favre P, Polosan M, Pichat C, Bougerol T, Baciu M - PLoS ONE (2015)

Results provided by between-group analyses.Panel A: Whole-brain comparison in HS vs BP during conflict monitoring (LR > HR) (p < 0.001 uncorrected at whole brain level, pFWE < 0.05 after small volume correction). Identified regions are projected onto 2D anatomical slices in axial, coronal and sagittal orientations. Panel B: Region of interest analysis focused on bilateral amygdala. The graph shows the mean %MR signal intensity variations ± SE according to the group and the amount of the conflict (LR vs HR). *p<0.05. Abbreviations: BP: Bipolar patients; HS: Healthy subjects; LR: Low conflict resolution; HR: High conflict resolution.
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4526683&req=5

pone.0134961.g004: Results provided by between-group analyses.Panel A: Whole-brain comparison in HS vs BP during conflict monitoring (LR > HR) (p < 0.001 uncorrected at whole brain level, pFWE < 0.05 after small volume correction). Identified regions are projected onto 2D anatomical slices in axial, coronal and sagittal orientations. Panel B: Region of interest analysis focused on bilateral amygdala. The graph shows the mean %MR signal intensity variations ± SE according to the group and the amount of the conflict (LR vs HR). *p<0.05. Abbreviations: BP: Bipolar patients; HS: Healthy subjects; LR: Low conflict resolution; HR: High conflict resolution.
Mentions: The conflict Monitoring contrast revealed stronger activation in HS in comparison to BP in frontal regions including the right middle (dorsolateral part) and superior frontal gyri, as well as in the left middle temporal and left supramarginal gyri (Fig 4A, Table 3). No regions were significantly more activated in BP compared to HS. The conflict Resolution contrast did not reveal significant differences between groups.

Bottom Line: Furthermore, BP showed decreased activation of the right dorsolateral prefrontal cortex (DLPFC) during the monitoring and a lack of bilateral amygdala deactivation during the resolution of the emotional conflict.Overall, our results highlighted dysfunctional processing of the emotion conflict in euthymic BP that may be subtended by abnormal activity and connectivity of the DLPFC during the conflict monitoring, which, in turn, leads to failure of amygdala deactivation during the resolution of the conflict.Emotional dysregulation in BP may be underpinned by a lack of top-down cognitive control and a difficulty to focus on the task due to persistent self-oriented attention.

View Article: PubMed Central - PubMed

Affiliation: Univ. Grenoble Alpes, LPNC, CNRS UMR 5105, Grenoble, France.

ABSTRACT

Background: Patients with bipolar disorder experience cognitive and emotional impairment that may persist even during the euthymic state of the disease. These persistent symptoms in bipolar patients (BP) may be characterized by disturbances of emotion regulation and related fronto-limbic brain circuitry. The present study aims to investigate the modulation of fronto-limbic activity and connectivity in BP by the processing of emotional conflict.

Methods: Fourteen euthymic BP and 13 matched healthy subjects (HS) underwent functional magnetic resonance imaging (fMRI) while performing a word-face emotional Stroop task designed to dissociate the monitoring/generation of emotional conflict from its resolution. Functional connectivity was determined by means of psychophysiological interaction (PPI) approach.

Results: Relative to HS, BP were slower to process incongruent stimuli, reflecting higher amount of behavioral interference during emotional Stroop. Furthermore, BP showed decreased activation of the right dorsolateral prefrontal cortex (DLPFC) during the monitoring and a lack of bilateral amygdala deactivation during the resolution of the emotional conflict. In addition, during conflict monitoring, BP showed abnormal positive connectivity between the right DLPFC and several regions of the default mode network.

Conclusions: Overall, our results highlighted dysfunctional processing of the emotion conflict in euthymic BP that may be subtended by abnormal activity and connectivity of the DLPFC during the conflict monitoring, which, in turn, leads to failure of amygdala deactivation during the resolution of the conflict. Emotional dysregulation in BP may be underpinned by a lack of top-down cognitive control and a difficulty to focus on the task due to persistent self-oriented attention.

No MeSH data available.


Related in: MedlinePlus