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Cerebral Correlates of Abnormal Emotion Conflict Processing in Euthymic Bipolar Patients: A Functional MRI Study.

Favre P, Polosan M, Pichat C, Bougerol T, Baciu M - PLoS ONE (2015)

Bottom Line: Furthermore, BP showed decreased activation of the right dorsolateral prefrontal cortex (DLPFC) during the monitoring and a lack of bilateral amygdala deactivation during the resolution of the emotional conflict.Overall, our results highlighted dysfunctional processing of the emotion conflict in euthymic BP that may be subtended by abnormal activity and connectivity of the DLPFC during the conflict monitoring, which, in turn, leads to failure of amygdala deactivation during the resolution of the conflict.Emotional dysregulation in BP may be underpinned by a lack of top-down cognitive control and a difficulty to focus on the task due to persistent self-oriented attention.

View Article: PubMed Central - PubMed

Affiliation: Univ. Grenoble Alpes, LPNC, CNRS UMR 5105, Grenoble, France.

ABSTRACT

Background: Patients with bipolar disorder experience cognitive and emotional impairment that may persist even during the euthymic state of the disease. These persistent symptoms in bipolar patients (BP) may be characterized by disturbances of emotion regulation and related fronto-limbic brain circuitry. The present study aims to investigate the modulation of fronto-limbic activity and connectivity in BP by the processing of emotional conflict.

Methods: Fourteen euthymic BP and 13 matched healthy subjects (HS) underwent functional magnetic resonance imaging (fMRI) while performing a word-face emotional Stroop task designed to dissociate the monitoring/generation of emotional conflict from its resolution. Functional connectivity was determined by means of psychophysiological interaction (PPI) approach.

Results: Relative to HS, BP were slower to process incongruent stimuli, reflecting higher amount of behavioral interference during emotional Stroop. Furthermore, BP showed decreased activation of the right dorsolateral prefrontal cortex (DLPFC) during the monitoring and a lack of bilateral amygdala deactivation during the resolution of the emotional conflict. In addition, during conflict monitoring, BP showed abnormal positive connectivity between the right DLPFC and several regions of the default mode network.

Conclusions: Overall, our results highlighted dysfunctional processing of the emotion conflict in euthymic BP that may be subtended by abnormal activity and connectivity of the DLPFC during the conflict monitoring, which, in turn, leads to failure of amygdala deactivation during the resolution of the conflict. Emotional dysregulation in BP may be underpinned by a lack of top-down cognitive control and a difficulty to focus on the task due to persistent self-oriented attention.

No MeSH data available.


Related in: MedlinePlus

Results of the within-group analyses at whole-brain level during conflict monitoring in (A) healthy subjects and (B) euthymic bipolar patients.Identified regions are projected onto 2D anatomical slices in axial, coronal and sagittal orientations (p < 0.001 uncorrected at whole brain level, pFWE < 0.05 after small volume correction).
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pone.0134961.g003: Results of the within-group analyses at whole-brain level during conflict monitoring in (A) healthy subjects and (B) euthymic bipolar patients.Identified regions are projected onto 2D anatomical slices in axial, coronal and sagittal orientations (p < 0.001 uncorrected at whole brain level, pFWE < 0.05 after small volume correction).

Mentions: In HS the conflict Monitoring contrast (LR > HR) induced activation within the superior frontal, insula, bilateral middle temporal, right inferior temporal, left supramarginal and left middle occipital gyri (Fig 3A, Table 3). In BP, the same contrast elicited brain activation within the bilateral dorsal thalamus only (Fig 3B, Table 3). The opposite contrast (i.e., conflict Resolution contrast: HR > LR) did not reveal suprathreshold voxels, neither for HS nor for BP.


Cerebral Correlates of Abnormal Emotion Conflict Processing in Euthymic Bipolar Patients: A Functional MRI Study.

Favre P, Polosan M, Pichat C, Bougerol T, Baciu M - PLoS ONE (2015)

Results of the within-group analyses at whole-brain level during conflict monitoring in (A) healthy subjects and (B) euthymic bipolar patients.Identified regions are projected onto 2D anatomical slices in axial, coronal and sagittal orientations (p < 0.001 uncorrected at whole brain level, pFWE < 0.05 after small volume correction).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4526683&req=5

pone.0134961.g003: Results of the within-group analyses at whole-brain level during conflict monitoring in (A) healthy subjects and (B) euthymic bipolar patients.Identified regions are projected onto 2D anatomical slices in axial, coronal and sagittal orientations (p < 0.001 uncorrected at whole brain level, pFWE < 0.05 after small volume correction).
Mentions: In HS the conflict Monitoring contrast (LR > HR) induced activation within the superior frontal, insula, bilateral middle temporal, right inferior temporal, left supramarginal and left middle occipital gyri (Fig 3A, Table 3). In BP, the same contrast elicited brain activation within the bilateral dorsal thalamus only (Fig 3B, Table 3). The opposite contrast (i.e., conflict Resolution contrast: HR > LR) did not reveal suprathreshold voxels, neither for HS nor for BP.

Bottom Line: Furthermore, BP showed decreased activation of the right dorsolateral prefrontal cortex (DLPFC) during the monitoring and a lack of bilateral amygdala deactivation during the resolution of the emotional conflict.Overall, our results highlighted dysfunctional processing of the emotion conflict in euthymic BP that may be subtended by abnormal activity and connectivity of the DLPFC during the conflict monitoring, which, in turn, leads to failure of amygdala deactivation during the resolution of the conflict.Emotional dysregulation in BP may be underpinned by a lack of top-down cognitive control and a difficulty to focus on the task due to persistent self-oriented attention.

View Article: PubMed Central - PubMed

Affiliation: Univ. Grenoble Alpes, LPNC, CNRS UMR 5105, Grenoble, France.

ABSTRACT

Background: Patients with bipolar disorder experience cognitive and emotional impairment that may persist even during the euthymic state of the disease. These persistent symptoms in bipolar patients (BP) may be characterized by disturbances of emotion regulation and related fronto-limbic brain circuitry. The present study aims to investigate the modulation of fronto-limbic activity and connectivity in BP by the processing of emotional conflict.

Methods: Fourteen euthymic BP and 13 matched healthy subjects (HS) underwent functional magnetic resonance imaging (fMRI) while performing a word-face emotional Stroop task designed to dissociate the monitoring/generation of emotional conflict from its resolution. Functional connectivity was determined by means of psychophysiological interaction (PPI) approach.

Results: Relative to HS, BP were slower to process incongruent stimuli, reflecting higher amount of behavioral interference during emotional Stroop. Furthermore, BP showed decreased activation of the right dorsolateral prefrontal cortex (DLPFC) during the monitoring and a lack of bilateral amygdala deactivation during the resolution of the emotional conflict. In addition, during conflict monitoring, BP showed abnormal positive connectivity between the right DLPFC and several regions of the default mode network.

Conclusions: Overall, our results highlighted dysfunctional processing of the emotion conflict in euthymic BP that may be subtended by abnormal activity and connectivity of the DLPFC during the conflict monitoring, which, in turn, leads to failure of amygdala deactivation during the resolution of the conflict. Emotional dysregulation in BP may be underpinned by a lack of top-down cognitive control and a difficulty to focus on the task due to persistent self-oriented attention.

No MeSH data available.


Related in: MedlinePlus