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Cerebral Correlates of Abnormal Emotion Conflict Processing in Euthymic Bipolar Patients: A Functional MRI Study.

Favre P, Polosan M, Pichat C, Bougerol T, Baciu M - PLoS ONE (2015)

Bottom Line: Furthermore, BP showed decreased activation of the right dorsolateral prefrontal cortex (DLPFC) during the monitoring and a lack of bilateral amygdala deactivation during the resolution of the emotional conflict.Overall, our results highlighted dysfunctional processing of the emotion conflict in euthymic BP that may be subtended by abnormal activity and connectivity of the DLPFC during the conflict monitoring, which, in turn, leads to failure of amygdala deactivation during the resolution of the conflict.Emotional dysregulation in BP may be underpinned by a lack of top-down cognitive control and a difficulty to focus on the task due to persistent self-oriented attention.

View Article: PubMed Central - PubMed

Affiliation: Univ. Grenoble Alpes, LPNC, CNRS UMR 5105, Grenoble, France.

ABSTRACT

Background: Patients with bipolar disorder experience cognitive and emotional impairment that may persist even during the euthymic state of the disease. These persistent symptoms in bipolar patients (BP) may be characterized by disturbances of emotion regulation and related fronto-limbic brain circuitry. The present study aims to investigate the modulation of fronto-limbic activity and connectivity in BP by the processing of emotional conflict.

Methods: Fourteen euthymic BP and 13 matched healthy subjects (HS) underwent functional magnetic resonance imaging (fMRI) while performing a word-face emotional Stroop task designed to dissociate the monitoring/generation of emotional conflict from its resolution. Functional connectivity was determined by means of psychophysiological interaction (PPI) approach.

Results: Relative to HS, BP were slower to process incongruent stimuli, reflecting higher amount of behavioral interference during emotional Stroop. Furthermore, BP showed decreased activation of the right dorsolateral prefrontal cortex (DLPFC) during the monitoring and a lack of bilateral amygdala deactivation during the resolution of the emotional conflict. In addition, during conflict monitoring, BP showed abnormal positive connectivity between the right DLPFC and several regions of the default mode network.

Conclusions: Overall, our results highlighted dysfunctional processing of the emotion conflict in euthymic BP that may be subtended by abnormal activity and connectivity of the DLPFC during the conflict monitoring, which, in turn, leads to failure of amygdala deactivation during the resolution of the conflict. Emotional dysregulation in BP may be underpinned by a lack of top-down cognitive control and a difficulty to focus on the task due to persistent self-oriented attention.

No MeSH data available.


Related in: MedlinePlus

Behavioral performances during word-face emotional Stroop.Panel A: Illustration of behavioral dissociation between conflict monitoring and conflict resolution. The graph shows the mean response time ± SE according to the congruency of the current trial and the congruency of the previous trial. Panel B: Illustration of the increase emotional interference in euthymic bipolar patients. The graph shows the mean response time ± SE according to the group and the congruency of the current trial. *p<0.05. Abbreviations: LR: Low conflict resolution; HR: High conflict resolution; NC: No conflict.
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pone.0134961.g002: Behavioral performances during word-face emotional Stroop.Panel A: Illustration of behavioral dissociation between conflict monitoring and conflict resolution. The graph shows the mean response time ± SE according to the congruency of the current trial and the congruency of the previous trial. Panel B: Illustration of the increase emotional interference in euthymic bipolar patients. The graph shows the mean response time ± SE according to the group and the congruency of the current trial. *p<0.05. Abbreviations: LR: Low conflict resolution; HR: High conflict resolution; NC: No conflict.

Mentions: All conditions combined, BP patients were marginally slower [F(1, 25) = 3.93; ηp2 = 0.14; P = 0.06] but in terms of %CR they were comparable to HS [F(1, 25) = 0.39; Ηp2 = 0.01; P = 0.09]. ANOVAs revealed a significant main effect of emotional conflict conditions in BP and HS for both RT [F(3, 75) = 23.73; Ηp2 = 0.49; P < 0.001] and %CR [F(3, 75) = 9.09; Ηp2 = 0.27; P < 0.001]. Planned comparisons confirmed a strong interference effect (incongruent vs. congruent) on both RT [F(1, 25) = 39.26; P < 0.001] and %CR [F(1, 25) = 14.65; P < 0.001]. Furthermore, the RT was lower for LR than for HR trials [F(1, 25) = 6.84; P = 0.01], highlighting the dissociation between monitoring and resolution processes at behavioral level (Fig 2A). A significant Group by Condition interaction was also observed on RT [F(3, 75) = 3.87; Ηp2 = 0.13; P = 0.01]. Planned comparisons showed that BP were significantly slower than HS for processing incongruent stimuli [F(1, 25) = 6.42; P = 0.02] (Fig 2B). However, there was no significant difference between BP and HS according to the amount of the conflict, i.e., LR vs HR trials [F(1, 25) = 1.61; P = 0.22]. Descriptive statistics are summarized in Table 2.


Cerebral Correlates of Abnormal Emotion Conflict Processing in Euthymic Bipolar Patients: A Functional MRI Study.

Favre P, Polosan M, Pichat C, Bougerol T, Baciu M - PLoS ONE (2015)

Behavioral performances during word-face emotional Stroop.Panel A: Illustration of behavioral dissociation between conflict monitoring and conflict resolution. The graph shows the mean response time ± SE according to the congruency of the current trial and the congruency of the previous trial. Panel B: Illustration of the increase emotional interference in euthymic bipolar patients. The graph shows the mean response time ± SE according to the group and the congruency of the current trial. *p<0.05. Abbreviations: LR: Low conflict resolution; HR: High conflict resolution; NC: No conflict.
© Copyright Policy
Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC4526683&req=5

pone.0134961.g002: Behavioral performances during word-face emotional Stroop.Panel A: Illustration of behavioral dissociation between conflict monitoring and conflict resolution. The graph shows the mean response time ± SE according to the congruency of the current trial and the congruency of the previous trial. Panel B: Illustration of the increase emotional interference in euthymic bipolar patients. The graph shows the mean response time ± SE according to the group and the congruency of the current trial. *p<0.05. Abbreviations: LR: Low conflict resolution; HR: High conflict resolution; NC: No conflict.
Mentions: All conditions combined, BP patients were marginally slower [F(1, 25) = 3.93; ηp2 = 0.14; P = 0.06] but in terms of %CR they were comparable to HS [F(1, 25) = 0.39; Ηp2 = 0.01; P = 0.09]. ANOVAs revealed a significant main effect of emotional conflict conditions in BP and HS for both RT [F(3, 75) = 23.73; Ηp2 = 0.49; P < 0.001] and %CR [F(3, 75) = 9.09; Ηp2 = 0.27; P < 0.001]. Planned comparisons confirmed a strong interference effect (incongruent vs. congruent) on both RT [F(1, 25) = 39.26; P < 0.001] and %CR [F(1, 25) = 14.65; P < 0.001]. Furthermore, the RT was lower for LR than for HR trials [F(1, 25) = 6.84; P = 0.01], highlighting the dissociation between monitoring and resolution processes at behavioral level (Fig 2A). A significant Group by Condition interaction was also observed on RT [F(3, 75) = 3.87; Ηp2 = 0.13; P = 0.01]. Planned comparisons showed that BP were significantly slower than HS for processing incongruent stimuli [F(1, 25) = 6.42; P = 0.02] (Fig 2B). However, there was no significant difference between BP and HS according to the amount of the conflict, i.e., LR vs HR trials [F(1, 25) = 1.61; P = 0.22]. Descriptive statistics are summarized in Table 2.

Bottom Line: Furthermore, BP showed decreased activation of the right dorsolateral prefrontal cortex (DLPFC) during the monitoring and a lack of bilateral amygdala deactivation during the resolution of the emotional conflict.Overall, our results highlighted dysfunctional processing of the emotion conflict in euthymic BP that may be subtended by abnormal activity and connectivity of the DLPFC during the conflict monitoring, which, in turn, leads to failure of amygdala deactivation during the resolution of the conflict.Emotional dysregulation in BP may be underpinned by a lack of top-down cognitive control and a difficulty to focus on the task due to persistent self-oriented attention.

View Article: PubMed Central - PubMed

Affiliation: Univ. Grenoble Alpes, LPNC, CNRS UMR 5105, Grenoble, France.

ABSTRACT

Background: Patients with bipolar disorder experience cognitive and emotional impairment that may persist even during the euthymic state of the disease. These persistent symptoms in bipolar patients (BP) may be characterized by disturbances of emotion regulation and related fronto-limbic brain circuitry. The present study aims to investigate the modulation of fronto-limbic activity and connectivity in BP by the processing of emotional conflict.

Methods: Fourteen euthymic BP and 13 matched healthy subjects (HS) underwent functional magnetic resonance imaging (fMRI) while performing a word-face emotional Stroop task designed to dissociate the monitoring/generation of emotional conflict from its resolution. Functional connectivity was determined by means of psychophysiological interaction (PPI) approach.

Results: Relative to HS, BP were slower to process incongruent stimuli, reflecting higher amount of behavioral interference during emotional Stroop. Furthermore, BP showed decreased activation of the right dorsolateral prefrontal cortex (DLPFC) during the monitoring and a lack of bilateral amygdala deactivation during the resolution of the emotional conflict. In addition, during conflict monitoring, BP showed abnormal positive connectivity between the right DLPFC and several regions of the default mode network.

Conclusions: Overall, our results highlighted dysfunctional processing of the emotion conflict in euthymic BP that may be subtended by abnormal activity and connectivity of the DLPFC during the conflict monitoring, which, in turn, leads to failure of amygdala deactivation during the resolution of the conflict. Emotional dysregulation in BP may be underpinned by a lack of top-down cognitive control and a difficulty to focus on the task due to persistent self-oriented attention.

No MeSH data available.


Related in: MedlinePlus