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Brain morphology of childhood aggressive behavior: A multi-informant study in school-age children.

Thijssen S, Ringoot AP, Wildeboer A, Bakermans-Kranenburg MJ, El Marroun H, Hofman A, Jaddoe VW, Verhulst FC, Tiemeier H, van IJzendoorn MH, White T - Cogn Affect Behav Neurosci (2015)

Bottom Line: Aggressive behavior was associated with smaller amygdala (p < .05) but not hippocampal volume.Moreover, aggression was associated with decreased gyrification in the right occipital and parietal cortex (p = .02).We found novel evidence that childhood aggressive behavior is related to decreased amygdala volume, decreased sensorimotor cortical thickness, and decreased global right hemisphere gyrification.

View Article: PubMed Central - PubMed

Affiliation: School of Pedagogical and Educational Sciences, Erasmus University Rotterdam, P.O. Box 1738, 3000, DR Rotterdam, The Netherlands.

ABSTRACT

Objective: Few studies have focused on the neuroanatomy of aggressive behavior in children younger than 10 years. Here, we explored the neuroanatomical correlates of aggression in a population-based sample of 6- to 9-year-old children using a multiple-informant approach.

Methods: Magnetic resonance (MR) scans were acquired from 566 children from the Generation R study who participated in the Berkeley Puppet Interview and whose parents had completed the Child Behavior Checklist. Linear regression analyses were used to examine associations between aggression and amygdala and hippocampal volume. We performed surface-based analyses to study the association between aggression and cortical thickness, surface area, and gyrification.

Results: Aggressive behavior was associated with smaller amygdala (p < .05) but not hippocampal volume. Aggression was associated with a thinner cortex in the left precentral cortex (p < .01) and in a cluster including the right inferior parietal, supramarginal, and postcentral cortex (p < .001). Gender moderated the association between aggression and cortical thickness in the right medial posterior cortex (p = .001) and the right prefrontal cortex (p < .001). Aggression was associated with decreased gyrification in a large cluster including the right precentral, postcentral, frontal, and parietal cortex (p = .01). Moreover, aggression was associated with decreased gyrification in the right occipital and parietal cortex (p = .02).

Conclusion: We found novel evidence that childhood aggressive behavior is related to decreased amygdala volume, decreased sensorimotor cortical thickness, and decreased global right hemisphere gyrification. Aggression is related to cortical thickness in regions associated with the default mode network, with negative associations in boys and positive associations in girls.

No MeSH data available.


Related in: MedlinePlus

Relation between cortical thickness and aggressive behavior. Sex, age, and IQ were used as covariates (Monte Carlo corrected cluster-wise p < .05). a) Cortical thickness was negatively associated with aggression in a cluster including the left precentral cortex and a cluster including the right inferior parietal, supramarginal, and postcentral cortex (i.e., reduced cortical thickness was associated with more aggressive behavior). b) A moderating effect of gender was found for a cluster including the right middle frontal, and superior frontal cortex and for a cluster including the right precuneus, isthmus of the cingulate cortex, and lingual cortex, with negative associations in boys and positive associations in girls. Colors represent –log10 p-value
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Fig1: Relation between cortical thickness and aggressive behavior. Sex, age, and IQ were used as covariates (Monte Carlo corrected cluster-wise p < .05). a) Cortical thickness was negatively associated with aggression in a cluster including the left precentral cortex and a cluster including the right inferior parietal, supramarginal, and postcentral cortex (i.e., reduced cortical thickness was associated with more aggressive behavior). b) A moderating effect of gender was found for a cluster including the right middle frontal, and superior frontal cortex and for a cluster including the right precuneus, isthmus of the cingulate cortex, and lingual cortex, with negative associations in boys and positive associations in girls. Colors represent –log10 p-value

Mentions: Aggressive behavior was associated with reduced cortical thickness in a cluster including the left precentral cortex (1,150 mm2, max vertex X = −52.5, Y = −6.6, Z = 38.5, p = .005) and a cluster including the right inferior parietal, supramarginal, and postcentral cortex (2,139 mm2, max vertex X = 42.9, Y = −27.6, Z = 37.6, p < .001, Fig. 1a). Gender moderated the association between aggression and cortical thickness in a cluster including the right precuneus, isthmus of the cingulate cortex, and lingual cortex (1,344 mm2, max vertex X = 8.5, Y = −53.1, Z = 20.4, p = .001), as well as in a cluster covering the right middle and superior frontal cortex (2,067 mm2, max vertex X = 34.4, Y = 49.8, Z = 7.7, p < .001, Fig. 1b).Fig. 1


Brain morphology of childhood aggressive behavior: A multi-informant study in school-age children.

Thijssen S, Ringoot AP, Wildeboer A, Bakermans-Kranenburg MJ, El Marroun H, Hofman A, Jaddoe VW, Verhulst FC, Tiemeier H, van IJzendoorn MH, White T - Cogn Affect Behav Neurosci (2015)

Relation between cortical thickness and aggressive behavior. Sex, age, and IQ were used as covariates (Monte Carlo corrected cluster-wise p < .05). a) Cortical thickness was negatively associated with aggression in a cluster including the left precentral cortex and a cluster including the right inferior parietal, supramarginal, and postcentral cortex (i.e., reduced cortical thickness was associated with more aggressive behavior). b) A moderating effect of gender was found for a cluster including the right middle frontal, and superior frontal cortex and for a cluster including the right precuneus, isthmus of the cingulate cortex, and lingual cortex, with negative associations in boys and positive associations in girls. Colors represent –log10 p-value
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4526589&req=5

Fig1: Relation between cortical thickness and aggressive behavior. Sex, age, and IQ were used as covariates (Monte Carlo corrected cluster-wise p < .05). a) Cortical thickness was negatively associated with aggression in a cluster including the left precentral cortex and a cluster including the right inferior parietal, supramarginal, and postcentral cortex (i.e., reduced cortical thickness was associated with more aggressive behavior). b) A moderating effect of gender was found for a cluster including the right middle frontal, and superior frontal cortex and for a cluster including the right precuneus, isthmus of the cingulate cortex, and lingual cortex, with negative associations in boys and positive associations in girls. Colors represent –log10 p-value
Mentions: Aggressive behavior was associated with reduced cortical thickness in a cluster including the left precentral cortex (1,150 mm2, max vertex X = −52.5, Y = −6.6, Z = 38.5, p = .005) and a cluster including the right inferior parietal, supramarginal, and postcentral cortex (2,139 mm2, max vertex X = 42.9, Y = −27.6, Z = 37.6, p < .001, Fig. 1a). Gender moderated the association between aggression and cortical thickness in a cluster including the right precuneus, isthmus of the cingulate cortex, and lingual cortex (1,344 mm2, max vertex X = 8.5, Y = −53.1, Z = 20.4, p = .001), as well as in a cluster covering the right middle and superior frontal cortex (2,067 mm2, max vertex X = 34.4, Y = 49.8, Z = 7.7, p < .001, Fig. 1b).Fig. 1

Bottom Line: Aggressive behavior was associated with smaller amygdala (p < .05) but not hippocampal volume.Moreover, aggression was associated with decreased gyrification in the right occipital and parietal cortex (p = .02).We found novel evidence that childhood aggressive behavior is related to decreased amygdala volume, decreased sensorimotor cortical thickness, and decreased global right hemisphere gyrification.

View Article: PubMed Central - PubMed

Affiliation: School of Pedagogical and Educational Sciences, Erasmus University Rotterdam, P.O. Box 1738, 3000, DR Rotterdam, The Netherlands.

ABSTRACT

Objective: Few studies have focused on the neuroanatomy of aggressive behavior in children younger than 10 years. Here, we explored the neuroanatomical correlates of aggression in a population-based sample of 6- to 9-year-old children using a multiple-informant approach.

Methods: Magnetic resonance (MR) scans were acquired from 566 children from the Generation R study who participated in the Berkeley Puppet Interview and whose parents had completed the Child Behavior Checklist. Linear regression analyses were used to examine associations between aggression and amygdala and hippocampal volume. We performed surface-based analyses to study the association between aggression and cortical thickness, surface area, and gyrification.

Results: Aggressive behavior was associated with smaller amygdala (p < .05) but not hippocampal volume. Aggression was associated with a thinner cortex in the left precentral cortex (p < .01) and in a cluster including the right inferior parietal, supramarginal, and postcentral cortex (p < .001). Gender moderated the association between aggression and cortical thickness in the right medial posterior cortex (p = .001) and the right prefrontal cortex (p < .001). Aggression was associated with decreased gyrification in a large cluster including the right precentral, postcentral, frontal, and parietal cortex (p = .01). Moreover, aggression was associated with decreased gyrification in the right occipital and parietal cortex (p = .02).

Conclusion: We found novel evidence that childhood aggressive behavior is related to decreased amygdala volume, decreased sensorimotor cortical thickness, and decreased global right hemisphere gyrification. Aggression is related to cortical thickness in regions associated with the default mode network, with negative associations in boys and positive associations in girls.

No MeSH data available.


Related in: MedlinePlus