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Forecasting carbapenem resistance from antimicrobial consumption surveillance: Lessons learnt from an OXA-48-producing Klebsiella pneumoniae outbreak in a West London renal unit.

Gharbi M, Moore LS, Gilchrist M, Thomas CP, Bamford K, Brannigan ET, Holmes AH - Int. J. Antimicrob. Agents (2015)

Bottom Line: Analysis of alternative antimicrobials showed a significant increase in amikacin consumption post-intervention from 0.54 to 3.41 DDD/100OBD/year (slope +0.72, 95% CI 0.29-1.15; P=0.01).Total antimicrobials significantly decreased from 176.21 to 126.24 DDD/100OBD/year (P=0.05).Further validation using real-time data is needed.

View Article: PubMed Central - PubMed

Affiliation: The National Centre for Infection Prevention and Management, Imperial College London, Du Cane Road, London W12 ONN, UK. Electronic address: m.gharbi@imperial.ac.uk.

No MeSH data available.


Related in: MedlinePlus

Interrupted time series of meropenem consumption (in DDD/100OBD) before and after a targeted antimicrobial stewardship intervention in a renal cohort in West London, 2005–2014. DDD, defined daily doses; OBD, occupied bed-days.
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fig0015: Interrupted time series of meropenem consumption (in DDD/100OBD) before and after a targeted antimicrobial stewardship intervention in a renal cohort in West London, 2005–2014. DDD, defined daily doses; OBD, occupied bed-days.

Mentions: The impact of the antimicrobial stewardship intervention following the outbreak of OXA-48-producing K. pneumoniae on meropenem consumption is depicted in Fig. 3.


Forecasting carbapenem resistance from antimicrobial consumption surveillance: Lessons learnt from an OXA-48-producing Klebsiella pneumoniae outbreak in a West London renal unit.

Gharbi M, Moore LS, Gilchrist M, Thomas CP, Bamford K, Brannigan ET, Holmes AH - Int. J. Antimicrob. Agents (2015)

Interrupted time series of meropenem consumption (in DDD/100OBD) before and after a targeted antimicrobial stewardship intervention in a renal cohort in West London, 2005–2014. DDD, defined daily doses; OBD, occupied bed-days.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4526541&req=5

fig0015: Interrupted time series of meropenem consumption (in DDD/100OBD) before and after a targeted antimicrobial stewardship intervention in a renal cohort in West London, 2005–2014. DDD, defined daily doses; OBD, occupied bed-days.
Mentions: The impact of the antimicrobial stewardship intervention following the outbreak of OXA-48-producing K. pneumoniae on meropenem consumption is depicted in Fig. 3.

Bottom Line: Analysis of alternative antimicrobials showed a significant increase in amikacin consumption post-intervention from 0.54 to 3.41 DDD/100OBD/year (slope +0.72, 95% CI 0.29-1.15; P=0.01).Total antimicrobials significantly decreased from 176.21 to 126.24 DDD/100OBD/year (P=0.05).Further validation using real-time data is needed.

View Article: PubMed Central - PubMed

Affiliation: The National Centre for Infection Prevention and Management, Imperial College London, Du Cane Road, London W12 ONN, UK. Electronic address: m.gharbi@imperial.ac.uk.

No MeSH data available.


Related in: MedlinePlus