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Evoked Potentials and Memory/Cognition Tests Validate Brain Atrophy as Measured by 3T MRI (NeuroQuant) in Cognitively Impaired Patients.

Braverman ER, Blum K, Hussman KL, Han D, Dushaj K, Li M, Marin G, Badgaiyan RD, Smayda R, Gold MS - PLoS ONE (2015)

Bottom Line: These results positively correlated with decreased P300 values and WMS-III (WMS-III) scores differentially across various brain loci.The correlation between working memory and reduced FA in frontal lobes is marginally significant (p=0.0787).Generally, the validation of brain atrophy by P300 and WMS-III could lead to cost-effective methods utilizable in primary care medicine following further confirmation.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, McKnight Brain Institute, University of Florida College of Medicine, Gainesville, Florida, United States of America; Department of Clinical Neurology, PATH Foundation NY, New York, New York, United States of America.

ABSTRACT
To our knowledge, this is the largest study evaluating relationships between 3T Magnetic Resonance Imaging (MRI) and P300 and memory/cognitive tests in the literature. The 3T MRI using NeuroQuant has an increased resolution 15 times that of 1.5T MRI. Utilizing NeuroQuant 3T MRI as a diagnostic tool in primary care, subjects (N=169; 19-90 years) displayed increased areas of anatomical atrophy: 34.62% hippocampal atrophy (N=54), 57.14% central atrophy (N=88), and 44.52% temporal atrophy (N=69). A majority of these patients exhibited overlap in measured areas of atrophy and were cognitively impaired. These results positively correlated with decreased P300 values and WMS-III (WMS-III) scores differentially across various brain loci. Delayed latency (p=0.0740) was marginally associated with temporal atrophy; reduced fractional anisotropy (FA) in frontal lobes correlated with aging, delayed P300 latency, and decreased visual and working memory (p=0.0115). Aging and delayed P300 latency correlated with lower FA. The correlation between working memory and reduced FA in frontal lobes is marginally significant (p=0.0787). In the centrum semiovale (CS), reduced FA correlated with visual memory (p=0.0622). Lower demyelination correlated with higher P300 amplitude (p=0.0002). Compared to males, females have higher demyelination (p=0.0064). Along these lines, the higher the P300 amplitude, the lower the bilateral atrophy (p=0.0165). Hippocampal atrophy correlated with increased auditory memory and gender, especially in males (p=0.0087). In considering temporal lobe atrophy correlations: delayed P300 latency and high temporal atrophy (p=0.0740); high auditory memory and low temporal atrophy (p=0.0417); and high working memory and low temporal atrophy (p=0.0166). Central atrophy correlated with aging and immediate memory (p=0.0294): the higher the immediate memory, the lower the central atrophy. Generally, the validation of brain atrophy by P300 and WMS-III could lead to cost-effective methods utilizable in primary care medicine following further confirmation.

No MeSH data available.


Related in: MedlinePlus

Logistic Regression Model for Concussion (ROC Curve: AUC = 0.647).
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pone.0133609.g005: Logistic Regression Model for Concussion (ROC Curve: AUC = 0.647).

Mentions: In order to assess whether any forms of atrophy (e.g. hippocampal, central, temporal) and lobe damages (e.g. frontal, parietal, occipital) are correlated with P300 latencies and amplitudes accounting for any (additive) effect of covariate measured in this study such as age and gender, multiple logistic regression models were constructed with certain atrophies and lobe damages as response variables. Final models were then built by reducing the full models through a mixed stepwise regression method. Only the main effects were considered in the model and dependency among the response variables was not considered for an individual examination of each response variable. Over 1000 combinatorial models were examined, and the following summarizes the results of each reduced model fit along with the effect estimates. The empirical receiver operating characteristic (ROC) curve illustrates the relationship between the sensitivity and the specificity under each model. The area under curve (AUC) value over 0.5 indicates a reasonable model fit (the higher the better) (Figs 5–13).


Evoked Potentials and Memory/Cognition Tests Validate Brain Atrophy as Measured by 3T MRI (NeuroQuant) in Cognitively Impaired Patients.

Braverman ER, Blum K, Hussman KL, Han D, Dushaj K, Li M, Marin G, Badgaiyan RD, Smayda R, Gold MS - PLoS ONE (2015)

Logistic Regression Model for Concussion (ROC Curve: AUC = 0.647).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4526533&req=5

pone.0133609.g005: Logistic Regression Model for Concussion (ROC Curve: AUC = 0.647).
Mentions: In order to assess whether any forms of atrophy (e.g. hippocampal, central, temporal) and lobe damages (e.g. frontal, parietal, occipital) are correlated with P300 latencies and amplitudes accounting for any (additive) effect of covariate measured in this study such as age and gender, multiple logistic regression models were constructed with certain atrophies and lobe damages as response variables. Final models were then built by reducing the full models through a mixed stepwise regression method. Only the main effects were considered in the model and dependency among the response variables was not considered for an individual examination of each response variable. Over 1000 combinatorial models were examined, and the following summarizes the results of each reduced model fit along with the effect estimates. The empirical receiver operating characteristic (ROC) curve illustrates the relationship between the sensitivity and the specificity under each model. The area under curve (AUC) value over 0.5 indicates a reasonable model fit (the higher the better) (Figs 5–13).

Bottom Line: These results positively correlated with decreased P300 values and WMS-III (WMS-III) scores differentially across various brain loci.The correlation between working memory and reduced FA in frontal lobes is marginally significant (p=0.0787).Generally, the validation of brain atrophy by P300 and WMS-III could lead to cost-effective methods utilizable in primary care medicine following further confirmation.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, McKnight Brain Institute, University of Florida College of Medicine, Gainesville, Florida, United States of America; Department of Clinical Neurology, PATH Foundation NY, New York, New York, United States of America.

ABSTRACT
To our knowledge, this is the largest study evaluating relationships between 3T Magnetic Resonance Imaging (MRI) and P300 and memory/cognitive tests in the literature. The 3T MRI using NeuroQuant has an increased resolution 15 times that of 1.5T MRI. Utilizing NeuroQuant 3T MRI as a diagnostic tool in primary care, subjects (N=169; 19-90 years) displayed increased areas of anatomical atrophy: 34.62% hippocampal atrophy (N=54), 57.14% central atrophy (N=88), and 44.52% temporal atrophy (N=69). A majority of these patients exhibited overlap in measured areas of atrophy and were cognitively impaired. These results positively correlated with decreased P300 values and WMS-III (WMS-III) scores differentially across various brain loci. Delayed latency (p=0.0740) was marginally associated with temporal atrophy; reduced fractional anisotropy (FA) in frontal lobes correlated with aging, delayed P300 latency, and decreased visual and working memory (p=0.0115). Aging and delayed P300 latency correlated with lower FA. The correlation between working memory and reduced FA in frontal lobes is marginally significant (p=0.0787). In the centrum semiovale (CS), reduced FA correlated with visual memory (p=0.0622). Lower demyelination correlated with higher P300 amplitude (p=0.0002). Compared to males, females have higher demyelination (p=0.0064). Along these lines, the higher the P300 amplitude, the lower the bilateral atrophy (p=0.0165). Hippocampal atrophy correlated with increased auditory memory and gender, especially in males (p=0.0087). In considering temporal lobe atrophy correlations: delayed P300 latency and high temporal atrophy (p=0.0740); high auditory memory and low temporal atrophy (p=0.0417); and high working memory and low temporal atrophy (p=0.0166). Central atrophy correlated with aging and immediate memory (p=0.0294): the higher the immediate memory, the lower the central atrophy. Generally, the validation of brain atrophy by P300 and WMS-III could lead to cost-effective methods utilizable in primary care medicine following further confirmation.

No MeSH data available.


Related in: MedlinePlus