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Hydrothermal Synthesis and Biocompatibility Study of Highly Crystalline Carbonated Hydroxyapatite Nanorods.

Xue C, Chen Y, Huang Y, Zhu P - Nanoscale Res Lett (2015)

Bottom Line: Highly crystalline carbonated hydroxyapatite (CHA) nanorods with different carbonate contents were synthesized by a novel hydrothermal method.The biocompatibility of synthesized CHA nanorods was evaluated by cell viability and alkaline phosphatase (ALP) activity of MG-63 cell line.The biocompatibility evaluation results show that these CHA nanorods are biologically active apatites and potentially promising bone-substitute biomaterials for orthopedic application.

View Article: PubMed Central - PubMed

Affiliation: School of Chemistry and Chemical Engineering, Yangzhou University, Jiangsu, 225009, China.

ABSTRACT
Highly crystalline carbonated hydroxyapatite (CHA) nanorods with different carbonate contents were synthesized by a novel hydrothermal method. The crystallinity and chemical structure of synthesized nanorods were studied by Fourier transform infrared spectroscopy (FTIR), X-ray photo-electronic spectroscopy (XPS), X-ray diffraction (XRD), Raman spectroscopy, and transmission electron microscopy (TEM). The biocompatibility of synthesized CHA nanorods was evaluated by cell viability and alkaline phosphatase (ALP) activity of MG-63 cell line. The biocompatibility evaluation results show that these CHA nanorods are biologically active apatites and potentially promising bone-substitute biomaterials for orthopedic application.

No MeSH data available.


Related in: MedlinePlus

TEM image and SEAD pattern of synthesized nanorods: a HA; b CHA1; c CHA2; d CHA3
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Fig1: TEM image and SEAD pattern of synthesized nanorods: a HA; b CHA1; c CHA2; d CHA3

Mentions: TEM was used to characterize morphology and size of synthesized nanorods. Figure 1a shows that the synthesized HA nanorods have lengths of 60–90 nm and widths of 10–20 nm, which is similar to the size of human apatite crystals [20]. As carbonate content increase (Fig. 1a–d), the lengths of nanorods decrease and the widths slightly increase. The SEAD patterns shows multi-crystalline electron diffraction concentrate rings attributed to (002), (300), (310), and (211) crystallographic planes of hydroxyapatite [21–23].Fig. 1


Hydrothermal Synthesis and Biocompatibility Study of Highly Crystalline Carbonated Hydroxyapatite Nanorods.

Xue C, Chen Y, Huang Y, Zhu P - Nanoscale Res Lett (2015)

TEM image and SEAD pattern of synthesized nanorods: a HA; b CHA1; c CHA2; d CHA3
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4526508&req=5

Fig1: TEM image and SEAD pattern of synthesized nanorods: a HA; b CHA1; c CHA2; d CHA3
Mentions: TEM was used to characterize morphology and size of synthesized nanorods. Figure 1a shows that the synthesized HA nanorods have lengths of 60–90 nm and widths of 10–20 nm, which is similar to the size of human apatite crystals [20]. As carbonate content increase (Fig. 1a–d), the lengths of nanorods decrease and the widths slightly increase. The SEAD patterns shows multi-crystalline electron diffraction concentrate rings attributed to (002), (300), (310), and (211) crystallographic planes of hydroxyapatite [21–23].Fig. 1

Bottom Line: Highly crystalline carbonated hydroxyapatite (CHA) nanorods with different carbonate contents were synthesized by a novel hydrothermal method.The biocompatibility of synthesized CHA nanorods was evaluated by cell viability and alkaline phosphatase (ALP) activity of MG-63 cell line.The biocompatibility evaluation results show that these CHA nanorods are biologically active apatites and potentially promising bone-substitute biomaterials for orthopedic application.

View Article: PubMed Central - PubMed

Affiliation: School of Chemistry and Chemical Engineering, Yangzhou University, Jiangsu, 225009, China.

ABSTRACT
Highly crystalline carbonated hydroxyapatite (CHA) nanorods with different carbonate contents were synthesized by a novel hydrothermal method. The crystallinity and chemical structure of synthesized nanorods were studied by Fourier transform infrared spectroscopy (FTIR), X-ray photo-electronic spectroscopy (XPS), X-ray diffraction (XRD), Raman spectroscopy, and transmission electron microscopy (TEM). The biocompatibility of synthesized CHA nanorods was evaluated by cell viability and alkaline phosphatase (ALP) activity of MG-63 cell line. The biocompatibility evaluation results show that these CHA nanorods are biologically active apatites and potentially promising bone-substitute biomaterials for orthopedic application.

No MeSH data available.


Related in: MedlinePlus