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Psychometric evaluation of the Major Depression Inventory (MDI) as depression severity scale using the LEAD (Longitudinal Expert Assessment of All Data) as index of validity.

Bech P, Timmerby N, Martiny K, Lunde M, Soendergaard S - BMC Psychiatry (2015)

Bottom Line: Using the clinician-rated VAS depression severity scale, the conventional MDI cut-off scores for no or doubtful depression, and for mild, moderate and severe depression were confirmed.Using the VAS as index of external, clinical validity, the standardization of the MDI as a measure of depression severity was accepted, with an MDI cut-off score of 21 for mild depression, 26 for moderate depression severity, and 31 for severe depression.Martiny et al.

View Article: PubMed Central - PubMed

Affiliation: Psychiatric Research Unit, Psychiatric Centre North Zealand, Copenhagen University Hospital, Dyrehavevej 48, DK-3400, Hillerød, Denmark. per.bech@regionh.dk.

ABSTRACT

Background: The Major Depression Inventory (MDI) was developed to cover the universe of depressive symptoms in DSM-IV major depression as well as in ICD-10 mild, moderate, and severe depression. The objective of this study was to evaluate the standardization of the MDI as a depression severity scale using the Visual Analogue Scale (VAS) as index of external validity in accordance with the LEAD approach (Longitudinal Expert Assessment of All Data).

Methods: We used data from two previously published studies in which the patients had a MINI Neuropsychiatric Interview verified diagnosis of DSM-IV major depression. The conventional VAS scores for no, mild, moderate, and severe depression were used for the standardization of the MDI.

Results: The inter-correlation for the MDI with the clinician ratings (VAS, MES, HAM-D17 and HAM-D6) increased over the rating weeks in terms of Pearson coefficients. After nine weeks of therapy the coefficient ranged from 0.74 to 0.83. Using the clinician-rated VAS depression severity scale, the conventional MDI cut-off scores for no or doubtful depression, and for mild, moderate and severe depression were confirmed.

Conclusions: Using the VAS as index of external, clinical validity, the standardization of the MDI as a measure of depression severity was accepted, with an MDI cut-off score of 21 for mild depression, 26 for moderate depression severity, and 31 for severe depression.

Trial registration: Martiny et al. Acta Psychiatr Scand 112:117-25, 2005: None - due to trial commencement date. Straaso et al. Acta Neuropsychiatr 26:272-9; 2014: ClinicalTrials.gov ID NCT01353092 .

No MeSH data available.


Related in: MedlinePlus

Regression analysis using the VAS scores to arrive at the corresponding MDI scores by the formula MDI = 0.49 x VAS + 2.40 (N = 826)
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Fig2: Regression analysis using the VAS scores to arrive at the corresponding MDI scores by the formula MDI = 0.49 x VAS + 2.40 (N = 826)

Mentions: Figure 2 shows the regression analysis using the VAS scores to arrive at the corresponding MDI scores by the formula MDI = 0.49 x VAS + 2.40 (N = 826). The R2 was 0.55, indicating an acceptable goodness of fit. As indicated at the abscissa in Fig. 2 a VAS score of 50 is the average cut-off in moderate or major depression. Using the regression formula, a VAS score of 50 corresponds to a MDI score of 26.9 which is rather similar to the conventional MDI cut-off score of ≥ 26 (Fig. 1b). Using the regression formula, a VAS score of 60 corresponds to a MDI score of 31.8, which is rather similar to the conventional MDI cut-off score of ≥ 31 for severe depression (Fig. 1b). Similarly, a VAS score of 40 corresponds to a MDI score of 22.0, this is quite close to the conventional MDI cut-off ≥ 21 for mild depression (Fig. 1b). Finally, a VAS score of 30 corresponds to a MDI score of 17.1, this is rather close to the conventional MDI cut-off score of < 16 for no or doubtful depression (Fig. 1b).Fig. 2


Psychometric evaluation of the Major Depression Inventory (MDI) as depression severity scale using the LEAD (Longitudinal Expert Assessment of All Data) as index of validity.

Bech P, Timmerby N, Martiny K, Lunde M, Soendergaard S - BMC Psychiatry (2015)

Regression analysis using the VAS scores to arrive at the corresponding MDI scores by the formula MDI = 0.49 x VAS + 2.40 (N = 826)
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4526416&req=5

Fig2: Regression analysis using the VAS scores to arrive at the corresponding MDI scores by the formula MDI = 0.49 x VAS + 2.40 (N = 826)
Mentions: Figure 2 shows the regression analysis using the VAS scores to arrive at the corresponding MDI scores by the formula MDI = 0.49 x VAS + 2.40 (N = 826). The R2 was 0.55, indicating an acceptable goodness of fit. As indicated at the abscissa in Fig. 2 a VAS score of 50 is the average cut-off in moderate or major depression. Using the regression formula, a VAS score of 50 corresponds to a MDI score of 26.9 which is rather similar to the conventional MDI cut-off score of ≥ 26 (Fig. 1b). Using the regression formula, a VAS score of 60 corresponds to a MDI score of 31.8, which is rather similar to the conventional MDI cut-off score of ≥ 31 for severe depression (Fig. 1b). Similarly, a VAS score of 40 corresponds to a MDI score of 22.0, this is quite close to the conventional MDI cut-off ≥ 21 for mild depression (Fig. 1b). Finally, a VAS score of 30 corresponds to a MDI score of 17.1, this is rather close to the conventional MDI cut-off score of < 16 for no or doubtful depression (Fig. 1b).Fig. 2

Bottom Line: Using the clinician-rated VAS depression severity scale, the conventional MDI cut-off scores for no or doubtful depression, and for mild, moderate and severe depression were confirmed.Using the VAS as index of external, clinical validity, the standardization of the MDI as a measure of depression severity was accepted, with an MDI cut-off score of 21 for mild depression, 26 for moderate depression severity, and 31 for severe depression.Martiny et al.

View Article: PubMed Central - PubMed

Affiliation: Psychiatric Research Unit, Psychiatric Centre North Zealand, Copenhagen University Hospital, Dyrehavevej 48, DK-3400, Hillerød, Denmark. per.bech@regionh.dk.

ABSTRACT

Background: The Major Depression Inventory (MDI) was developed to cover the universe of depressive symptoms in DSM-IV major depression as well as in ICD-10 mild, moderate, and severe depression. The objective of this study was to evaluate the standardization of the MDI as a depression severity scale using the Visual Analogue Scale (VAS) as index of external validity in accordance with the LEAD approach (Longitudinal Expert Assessment of All Data).

Methods: We used data from two previously published studies in which the patients had a MINI Neuropsychiatric Interview verified diagnosis of DSM-IV major depression. The conventional VAS scores for no, mild, moderate, and severe depression were used for the standardization of the MDI.

Results: The inter-correlation for the MDI with the clinician ratings (VAS, MES, HAM-D17 and HAM-D6) increased over the rating weeks in terms of Pearson coefficients. After nine weeks of therapy the coefficient ranged from 0.74 to 0.83. Using the clinician-rated VAS depression severity scale, the conventional MDI cut-off scores for no or doubtful depression, and for mild, moderate and severe depression were confirmed.

Conclusions: Using the VAS as index of external, clinical validity, the standardization of the MDI as a measure of depression severity was accepted, with an MDI cut-off score of 21 for mild depression, 26 for moderate depression severity, and 31 for severe depression.

Trial registration: Martiny et al. Acta Psychiatr Scand 112:117-25, 2005: None - due to trial commencement date. Straaso et al. Acta Neuropsychiatr 26:272-9; 2014: ClinicalTrials.gov ID NCT01353092 .

No MeSH data available.


Related in: MedlinePlus