Limits...
Numerical optimization of targeted delivery of charged nanoparticles to the ostiomeatal complex for treatment of rhinosinusitis.

Xi J, Yuan JE, Si XA, Hasbany J - Int J Nanomedicine (2015)

Bottom Line: Through the synthesis of electric guidance and point drug release, the new delivery system eliminated particle deposition in the nasal valve and turbinate regions and significantly enhanced the OMC doses.The OMC dose increased from 45.0% in the baseline model to 72.4% in the optimized system.The optimization framework developed in this study can be easily adapted for the delivery of drugs to other sites in the nose such as the ethmoid sinus and olfactory region.

View Article: PubMed Central - PubMed

Affiliation: School of Engineering and Technology, Central Michigan University, Mount Pleasant, MI, USA.

ABSTRACT

Background: Despite the prevalence of rhinosinusitis that affects 10%-15% of the population, current inhalation therapy shows limited efficacy. Standard devices deliver <5% of the drugs to the sinuses due to the complexity of nose structure, secluded location of the sinus, poor ventilation, and lack of control of particle motions inside the nasal cavity.

Methods: An electric-guided delivery system was developed to guide charged particles to the ostiomeatal complex (OMC). Its performance was numerically assessed in an MRI-based nose-sinus model. Key design variables related to the delivery device, drug particles, and patient breathing were determined using sensitivity analysis. A two-stage optimization of design variables was conducted to obtain the best performance of the delivery system using the Nelder-Mead algorithm.

Results and discussion: The OMC delivery system exhibited high sensitivity to the applied electric field and electrostatic charges carried by the particles. Through the synthesis of electric guidance and point drug release, the new delivery system eliminated particle deposition in the nasal valve and turbinate regions and significantly enhanced the OMC doses. An OMC delivery efficiency of 72.4% was obtained with the optimized design, which is one order of magnitude higher than the standard nasal devices. Moreover, optimization is imperative to achieve a sound delivery protocol because of the large number of design variables. The OMC dose increased from 45.0% in the baseline model to 72.4% in the optimized system. The optimization framework developed in this study can be easily adapted for the delivery of drugs to other sites in the nose such as the ethmoid sinus and olfactory region.

No MeSH data available.


Related in: MedlinePlus

Sensitivity analysis of design variables influencing the OMC delivery efficiency.Notes: There are 14 design variables in total, which fall into three categories: device-related, particle-related, and patient-related. Each variable was varied by ±10% of the baseline value. The sensitivity results are shown as the percent change from the baseline OMC dose.Abbreviation: OMC, ostiomeatal complex.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4525801&req=5

f6-ijn-10-4847: Sensitivity analysis of design variables influencing the OMC delivery efficiency.Notes: There are 14 design variables in total, which fall into three categories: device-related, particle-related, and patient-related. Each variable was varied by ±10% of the baseline value. The sensitivity results are shown as the percent change from the baseline OMC dose.Abbreviation: OMC, ostiomeatal complex.

Mentions: Sensitivity analysis was conducted to examine the effects of individual parameters and identify key design variables (Figure 6). Each variable was tested by varying ±10% of the baseline value, and the result was shown as the percent change from the baseline OMC dosage. Different levels of sensitivity of the OMC deposition to the design variables were observed. It was highly sensitive to the inhalation rate, particle diameter, charge number, and electrode potential above the sinus ostium (C1). On the other hand, the influences of both inlet and the top electrodes (T2 and T3) are observed to be much smaller. This low sensitivity of the two top electrodes can presumably be explained by their indirect influence on the OMC dosage. It is also observed that B1, which lowers the particles in the valve region, exerts a much larger impact on OMC dosages than B2, which drives particles upward into the MM. No influence was observed from the particle density within the test range (±10%).


Numerical optimization of targeted delivery of charged nanoparticles to the ostiomeatal complex for treatment of rhinosinusitis.

Xi J, Yuan JE, Si XA, Hasbany J - Int J Nanomedicine (2015)

Sensitivity analysis of design variables influencing the OMC delivery efficiency.Notes: There are 14 design variables in total, which fall into three categories: device-related, particle-related, and patient-related. Each variable was varied by ±10% of the baseline value. The sensitivity results are shown as the percent change from the baseline OMC dose.Abbreviation: OMC, ostiomeatal complex.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4525801&req=5

f6-ijn-10-4847: Sensitivity analysis of design variables influencing the OMC delivery efficiency.Notes: There are 14 design variables in total, which fall into three categories: device-related, particle-related, and patient-related. Each variable was varied by ±10% of the baseline value. The sensitivity results are shown as the percent change from the baseline OMC dose.Abbreviation: OMC, ostiomeatal complex.
Mentions: Sensitivity analysis was conducted to examine the effects of individual parameters and identify key design variables (Figure 6). Each variable was tested by varying ±10% of the baseline value, and the result was shown as the percent change from the baseline OMC dosage. Different levels of sensitivity of the OMC deposition to the design variables were observed. It was highly sensitive to the inhalation rate, particle diameter, charge number, and electrode potential above the sinus ostium (C1). On the other hand, the influences of both inlet and the top electrodes (T2 and T3) are observed to be much smaller. This low sensitivity of the two top electrodes can presumably be explained by their indirect influence on the OMC dosage. It is also observed that B1, which lowers the particles in the valve region, exerts a much larger impact on OMC dosages than B2, which drives particles upward into the MM. No influence was observed from the particle density within the test range (±10%).

Bottom Line: Through the synthesis of electric guidance and point drug release, the new delivery system eliminated particle deposition in the nasal valve and turbinate regions and significantly enhanced the OMC doses.The OMC dose increased from 45.0% in the baseline model to 72.4% in the optimized system.The optimization framework developed in this study can be easily adapted for the delivery of drugs to other sites in the nose such as the ethmoid sinus and olfactory region.

View Article: PubMed Central - PubMed

Affiliation: School of Engineering and Technology, Central Michigan University, Mount Pleasant, MI, USA.

ABSTRACT

Background: Despite the prevalence of rhinosinusitis that affects 10%-15% of the population, current inhalation therapy shows limited efficacy. Standard devices deliver <5% of the drugs to the sinuses due to the complexity of nose structure, secluded location of the sinus, poor ventilation, and lack of control of particle motions inside the nasal cavity.

Methods: An electric-guided delivery system was developed to guide charged particles to the ostiomeatal complex (OMC). Its performance was numerically assessed in an MRI-based nose-sinus model. Key design variables related to the delivery device, drug particles, and patient breathing were determined using sensitivity analysis. A two-stage optimization of design variables was conducted to obtain the best performance of the delivery system using the Nelder-Mead algorithm.

Results and discussion: The OMC delivery system exhibited high sensitivity to the applied electric field and electrostatic charges carried by the particles. Through the synthesis of electric guidance and point drug release, the new delivery system eliminated particle deposition in the nasal valve and turbinate regions and significantly enhanced the OMC doses. An OMC delivery efficiency of 72.4% was obtained with the optimized design, which is one order of magnitude higher than the standard nasal devices. Moreover, optimization is imperative to achieve a sound delivery protocol because of the large number of design variables. The OMC dose increased from 45.0% in the baseline model to 72.4% in the optimized system. The optimization framework developed in this study can be easily adapted for the delivery of drugs to other sites in the nose such as the ethmoid sinus and olfactory region.

No MeSH data available.


Related in: MedlinePlus