Limits...
Numerical optimization of targeted delivery of charged nanoparticles to the ostiomeatal complex for treatment of rhinosinusitis.

Xi J, Yuan JE, Si XA, Hasbany J - Int J Nanomedicine (2015)

Bottom Line: Through the synthesis of electric guidance and point drug release, the new delivery system eliminated particle deposition in the nasal valve and turbinate regions and significantly enhanced the OMC doses.The OMC dose increased from 45.0% in the baseline model to 72.4% in the optimized system.The optimization framework developed in this study can be easily adapted for the delivery of drugs to other sites in the nose such as the ethmoid sinus and olfactory region.

View Article: PubMed Central - PubMed

Affiliation: School of Engineering and Technology, Central Michigan University, Mount Pleasant, MI, USA.

ABSTRACT

Background: Despite the prevalence of rhinosinusitis that affects 10%-15% of the population, current inhalation therapy shows limited efficacy. Standard devices deliver <5% of the drugs to the sinuses due to the complexity of nose structure, secluded location of the sinus, poor ventilation, and lack of control of particle motions inside the nasal cavity.

Methods: An electric-guided delivery system was developed to guide charged particles to the ostiomeatal complex (OMC). Its performance was numerically assessed in an MRI-based nose-sinus model. Key design variables related to the delivery device, drug particles, and patient breathing were determined using sensitivity analysis. A two-stage optimization of design variables was conducted to obtain the best performance of the delivery system using the Nelder-Mead algorithm.

Results and discussion: The OMC delivery system exhibited high sensitivity to the applied electric field and electrostatic charges carried by the particles. Through the synthesis of electric guidance and point drug release, the new delivery system eliminated particle deposition in the nasal valve and turbinate regions and significantly enhanced the OMC doses. An OMC delivery efficiency of 72.4% was obtained with the optimized design, which is one order of magnitude higher than the standard nasal devices. Moreover, optimization is imperative to achieve a sound delivery protocol because of the large number of design variables. The OMC dose increased from 45.0% in the baseline model to 72.4% in the optimized system. The optimization framework developed in this study can be easily adapted for the delivery of drugs to other sites in the nose such as the ethmoid sinus and olfactory region.

No MeSH data available.


Related in: MedlinePlus

Point-release position and particle deposition.Notes: (A) Selection of point-release position using an inverse method and (B) the resultant particle surface deposition without electric guidance. Particles that deposit in the sinus are traced back to their initial-release position. Particles introduced from the rectangle have more chances to enter the sinus. The area of the rectangle is fixed at 5.25 mm2, while the width and length (a × b) can change. An extremely low fraction of inhaled particles (0.1%) deposits in the sinus.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4525801&req=5

f3-ijn-10-4847: Point-release position and particle deposition.Notes: (A) Selection of point-release position using an inverse method and (B) the resultant particle surface deposition without electric guidance. Particles that deposit in the sinus are traced back to their initial-release position. Particles introduced from the rectangle have more chances to enter the sinus. The area of the rectangle is fixed at 5.25 mm2, while the width and length (a × b) can change. An extremely low fraction of inhaled particles (0.1%) deposits in the sinus.

Mentions: This section explains how design variables and their design spaces were selected. The particle size of the initial design was selected as 20 nm based on its high charge/mass ratio and high sensitivity to electric or magnetic controls. A slow inhalation rate (0.1 m/s) was chosen so that particles can have sufficient time to respond to the electric guidance. The layout of the electrodes was devised to minimize drug waste in regions other than the target. In particular, the selection of the point-release position and electromagnetic field is detailed in Figures 3 and 4, respectively.


Numerical optimization of targeted delivery of charged nanoparticles to the ostiomeatal complex for treatment of rhinosinusitis.

Xi J, Yuan JE, Si XA, Hasbany J - Int J Nanomedicine (2015)

Point-release position and particle deposition.Notes: (A) Selection of point-release position using an inverse method and (B) the resultant particle surface deposition without electric guidance. Particles that deposit in the sinus are traced back to their initial-release position. Particles introduced from the rectangle have more chances to enter the sinus. The area of the rectangle is fixed at 5.25 mm2, while the width and length (a × b) can change. An extremely low fraction of inhaled particles (0.1%) deposits in the sinus.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4525801&req=5

f3-ijn-10-4847: Point-release position and particle deposition.Notes: (A) Selection of point-release position using an inverse method and (B) the resultant particle surface deposition without electric guidance. Particles that deposit in the sinus are traced back to their initial-release position. Particles introduced from the rectangle have more chances to enter the sinus. The area of the rectangle is fixed at 5.25 mm2, while the width and length (a × b) can change. An extremely low fraction of inhaled particles (0.1%) deposits in the sinus.
Mentions: This section explains how design variables and their design spaces were selected. The particle size of the initial design was selected as 20 nm based on its high charge/mass ratio and high sensitivity to electric or magnetic controls. A slow inhalation rate (0.1 m/s) was chosen so that particles can have sufficient time to respond to the electric guidance. The layout of the electrodes was devised to minimize drug waste in regions other than the target. In particular, the selection of the point-release position and electromagnetic field is detailed in Figures 3 and 4, respectively.

Bottom Line: Through the synthesis of electric guidance and point drug release, the new delivery system eliminated particle deposition in the nasal valve and turbinate regions and significantly enhanced the OMC doses.The OMC dose increased from 45.0% in the baseline model to 72.4% in the optimized system.The optimization framework developed in this study can be easily adapted for the delivery of drugs to other sites in the nose such as the ethmoid sinus and olfactory region.

View Article: PubMed Central - PubMed

Affiliation: School of Engineering and Technology, Central Michigan University, Mount Pleasant, MI, USA.

ABSTRACT

Background: Despite the prevalence of rhinosinusitis that affects 10%-15% of the population, current inhalation therapy shows limited efficacy. Standard devices deliver <5% of the drugs to the sinuses due to the complexity of nose structure, secluded location of the sinus, poor ventilation, and lack of control of particle motions inside the nasal cavity.

Methods: An electric-guided delivery system was developed to guide charged particles to the ostiomeatal complex (OMC). Its performance was numerically assessed in an MRI-based nose-sinus model. Key design variables related to the delivery device, drug particles, and patient breathing were determined using sensitivity analysis. A two-stage optimization of design variables was conducted to obtain the best performance of the delivery system using the Nelder-Mead algorithm.

Results and discussion: The OMC delivery system exhibited high sensitivity to the applied electric field and electrostatic charges carried by the particles. Through the synthesis of electric guidance and point drug release, the new delivery system eliminated particle deposition in the nasal valve and turbinate regions and significantly enhanced the OMC doses. An OMC delivery efficiency of 72.4% was obtained with the optimized design, which is one order of magnitude higher than the standard nasal devices. Moreover, optimization is imperative to achieve a sound delivery protocol because of the large number of design variables. The OMC dose increased from 45.0% in the baseline model to 72.4% in the optimized system. The optimization framework developed in this study can be easily adapted for the delivery of drugs to other sites in the nose such as the ethmoid sinus and olfactory region.

No MeSH data available.


Related in: MedlinePlus