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Incidence and Potential Significance of Internal Mammary Lymphadenopathy on Computed Tomography in Patients with a Diagnosis of Primary Breast Cancer.

Savaridas SL, Spratt JD, Cox J - Breast Cancer (Auckl) (2015)

Bottom Line: However, 16% (25) had larger nodes, greater than 5 mm in short axis, present on CT.Significantly more patients with the presence of large (>5 mm) IMNs had more advanced disease with CT evidence of other distant spread.We suggest that further histological research is required to establish reliable CT size criterion for pathological IMNs.

View Article: PubMed Central - PubMed

Affiliation: University Hospital of North Durham, Durham, County Durham, UK. ; North Tyneside General Hospital, North Shields, Tyne-and-Wear, UK.

ABSTRACT

Introduction: The importance of internal mammary nodes (IMNs) in the staging and treatment of breast cancer patients is controversial.

Methods: A retrospective cohort of patients diagnosed with primary breast cancer over a 4-year period (January 2009 to December 2012) was assessed. The number and size of any IMNs visible on spiral computed tomography (CT) were recorded.

Results: A total of 830 patients were diagnosed with primary breast cancer within the identified time frame, of which 150 patients met the inclusion criteria. Of these 42% (63) had IMNs present, although the majority were small (<5 mm). However, 16% (25) had larger nodes, greater than 5 mm in short axis, present on CT. Significantly more patients with the presence of large (>5 mm) IMNs had more advanced disease with CT evidence of other distant spread.

Conclusion: We have demonstrated that IMNs are present in a substantial number of our primary breast cancer patients. We suggest that further histological research is required to establish reliable CT size criterion for pathological IMNs. In addition, routine imaging of the IM chain, as well as axilla, should be considered in the staging of breast cancer.

No MeSH data available.


Related in: MedlinePlus

Right IMN with no other evidence of distant spread.
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Related In: Results  -  Collection


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f3-bcbcr-9-2015-059: Right IMN with no other evidence of distant spread.

Mentions: Figure 2 illustrates a patient with prominent axillary adenopathy and a concurrent IMN measuring greater than 5 mm the in short axis. By comparison, Figure 3 illustrates a patient with no other evidence of distant spread on CT.


Incidence and Potential Significance of Internal Mammary Lymphadenopathy on Computed Tomography in Patients with a Diagnosis of Primary Breast Cancer.

Savaridas SL, Spratt JD, Cox J - Breast Cancer (Auckl) (2015)

Right IMN with no other evidence of distant spread.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4525791&req=5

f3-bcbcr-9-2015-059: Right IMN with no other evidence of distant spread.
Mentions: Figure 2 illustrates a patient with prominent axillary adenopathy and a concurrent IMN measuring greater than 5 mm the in short axis. By comparison, Figure 3 illustrates a patient with no other evidence of distant spread on CT.

Bottom Line: However, 16% (25) had larger nodes, greater than 5 mm in short axis, present on CT.Significantly more patients with the presence of large (>5 mm) IMNs had more advanced disease with CT evidence of other distant spread.We suggest that further histological research is required to establish reliable CT size criterion for pathological IMNs.

View Article: PubMed Central - PubMed

Affiliation: University Hospital of North Durham, Durham, County Durham, UK. ; North Tyneside General Hospital, North Shields, Tyne-and-Wear, UK.

ABSTRACT

Introduction: The importance of internal mammary nodes (IMNs) in the staging and treatment of breast cancer patients is controversial.

Methods: A retrospective cohort of patients diagnosed with primary breast cancer over a 4-year period (January 2009 to December 2012) was assessed. The number and size of any IMNs visible on spiral computed tomography (CT) were recorded.

Results: A total of 830 patients were diagnosed with primary breast cancer within the identified time frame, of which 150 patients met the inclusion criteria. Of these 42% (63) had IMNs present, although the majority were small (<5 mm). However, 16% (25) had larger nodes, greater than 5 mm in short axis, present on CT. Significantly more patients with the presence of large (>5 mm) IMNs had more advanced disease with CT evidence of other distant spread.

Conclusion: We have demonstrated that IMNs are present in a substantial number of our primary breast cancer patients. We suggest that further histological research is required to establish reliable CT size criterion for pathological IMNs. In addition, routine imaging of the IM chain, as well as axilla, should be considered in the staging of breast cancer.

No MeSH data available.


Related in: MedlinePlus