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Comparison of Measurement of Central Corneal Thickness with Spectral Domain Optical Coherence Tomography and Standard Ultrasonic Pachymeter in Premature Infants.

Hekimoglu E, Erol MK, Toslak D, Turgut Coban D, Doğan B, Yucel O - J Ophthalmol (2015)

Bottom Line: No statistically significant difference was found among the 3 CCT measurements by SD-OCT.Those results have been compared with each other.A statistically significant difference was found between the mean CCT measurements by SD-OCT and USP (p < 0.05).

View Article: PubMed Central - PubMed

Affiliation: Ophthalmology Department, Etlik Zubeyde Hanim Maternity and Women's Health Research Hospital, Yeni Etlik Caddesi No:55, Etlik, Keçiören, 06010 Ankara, Turkey.

ABSTRACT
Purpose. To evaluate the repeatability of measurement of central corneal thickness (CCT) by spectral domain optical coherence (SD-OCT) in premature infants and compare it to CCT measurement by ultrasonic pachymetry (USP). Methods. Three CCT measurements of the left eyes of 50 premature infants were obtained by SD-OCT using the iVue system. 10 CCT measurements of each 28 left eyes of 28 infants were obtained by USP using the Pacscan 300P system. Bland-Altman plots were developed and the limit of agreement (LoA) was determined to compare the mean of the SD-OCT and USP measurements. Results. No statistically significant difference was found among the 3 CCT measurements by SD-OCT. Both USP and SD-OCT have been performed for only left eyes of 28 of the 50 babies. Those results have been compared with each other. A statistically significant difference was found between the mean CCT measurements by SD-OCT and USP (p < 0.05). The LoA between the SD-OCT and USP measurements ranged from 11.4 to -64.1. Conclusions. CCT can be measured using the iVue SD-OCT system with a high level of repeatability. Although measurement of CCT by SD-OCT and USP is highly correlated, the 2 systems cannot be used interchangeably in premature infants.

No MeSH data available.


Printout of SD-OCT results showing measurement of CCT in three circles. The measurement in the innermost circle (2 mm) was accepted as the CCT value.
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fig2: Printout of SD-OCT results showing measurement of CCT in three circles. The measurement in the innermost circle (2 mm) was accepted as the CCT value.

Mentions: Of the 50 infants (28 females and 22 males) who participated in the study, SD-OCT measurements were able to be obtained from all 50 and USP measurements from 28. The mean gestational age of all 50 infants at birth was 30.5 ± 2.8 weeks (range 24–36 weeks) and the mean birth weight was 1507 ± 491 g. At measurement, the mean postmenstrual age (PMA) of all 50 infants was 39.7 ± 5.8 weeks and the mean weight was 3163 ± 1079 g. At measurement, the mean PMA of the 28 infants from whom USP measurements were obtained was 37.9 ± 3.7 weeks and the mean weight was 2926 ± 853. The mean CCT of the left eye of the 50 infants measured with SD-OCT was 541 ± 50 μm in the first measurement, 539 ± 46 μm in the second measurement, and 538 ± 51 μm in the third measurement (Figure 2 and Table 1). No significant difference was found among the three measurements obtained by SD-OCT. In contrast, a significant difference was found between the mean of the measurement of 28 infants obtained by USP, which was 576 ± 69 μm, and the mean of the three measurements, which was 549 ± 56 μm, of the same 28 infants obtained by SDOCT (p < 0.05).


Comparison of Measurement of Central Corneal Thickness with Spectral Domain Optical Coherence Tomography and Standard Ultrasonic Pachymeter in Premature Infants.

Hekimoglu E, Erol MK, Toslak D, Turgut Coban D, Doğan B, Yucel O - J Ophthalmol (2015)

Printout of SD-OCT results showing measurement of CCT in three circles. The measurement in the innermost circle (2 mm) was accepted as the CCT value.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4525755&req=5

fig2: Printout of SD-OCT results showing measurement of CCT in three circles. The measurement in the innermost circle (2 mm) was accepted as the CCT value.
Mentions: Of the 50 infants (28 females and 22 males) who participated in the study, SD-OCT measurements were able to be obtained from all 50 and USP measurements from 28. The mean gestational age of all 50 infants at birth was 30.5 ± 2.8 weeks (range 24–36 weeks) and the mean birth weight was 1507 ± 491 g. At measurement, the mean postmenstrual age (PMA) of all 50 infants was 39.7 ± 5.8 weeks and the mean weight was 3163 ± 1079 g. At measurement, the mean PMA of the 28 infants from whom USP measurements were obtained was 37.9 ± 3.7 weeks and the mean weight was 2926 ± 853. The mean CCT of the left eye of the 50 infants measured with SD-OCT was 541 ± 50 μm in the first measurement, 539 ± 46 μm in the second measurement, and 538 ± 51 μm in the third measurement (Figure 2 and Table 1). No significant difference was found among the three measurements obtained by SD-OCT. In contrast, a significant difference was found between the mean of the measurement of 28 infants obtained by USP, which was 576 ± 69 μm, and the mean of the three measurements, which was 549 ± 56 μm, of the same 28 infants obtained by SDOCT (p < 0.05).

Bottom Line: No statistically significant difference was found among the 3 CCT measurements by SD-OCT.Those results have been compared with each other.A statistically significant difference was found between the mean CCT measurements by SD-OCT and USP (p < 0.05).

View Article: PubMed Central - PubMed

Affiliation: Ophthalmology Department, Etlik Zubeyde Hanim Maternity and Women's Health Research Hospital, Yeni Etlik Caddesi No:55, Etlik, Keçiören, 06010 Ankara, Turkey.

ABSTRACT
Purpose. To evaluate the repeatability of measurement of central corneal thickness (CCT) by spectral domain optical coherence (SD-OCT) in premature infants and compare it to CCT measurement by ultrasonic pachymetry (USP). Methods. Three CCT measurements of the left eyes of 50 premature infants were obtained by SD-OCT using the iVue system. 10 CCT measurements of each 28 left eyes of 28 infants were obtained by USP using the Pacscan 300P system. Bland-Altman plots were developed and the limit of agreement (LoA) was determined to compare the mean of the SD-OCT and USP measurements. Results. No statistically significant difference was found among the 3 CCT measurements by SD-OCT. Both USP and SD-OCT have been performed for only left eyes of 28 of the 50 babies. Those results have been compared with each other. A statistically significant difference was found between the mean CCT measurements by SD-OCT and USP (p < 0.05). The LoA between the SD-OCT and USP measurements ranged from 11.4 to -64.1. Conclusions. CCT can be measured using the iVue SD-OCT system with a high level of repeatability. Although measurement of CCT by SD-OCT and USP is highly correlated, the 2 systems cannot be used interchangeably in premature infants.

No MeSH data available.