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Comparison of Measurement of Central Corneal Thickness with Spectral Domain Optical Coherence Tomography and Standard Ultrasonic Pachymeter in Premature Infants.

Hekimoglu E, Erol MK, Toslak D, Turgut Coban D, Doğan B, Yucel O - J Ophthalmol (2015)

Bottom Line: No statistically significant difference was found among the 3 CCT measurements by SD-OCT.Those results have been compared with each other.A statistically significant difference was found between the mean CCT measurements by SD-OCT and USP (p < 0.05).

View Article: PubMed Central - PubMed

Affiliation: Ophthalmology Department, Etlik Zubeyde Hanim Maternity and Women's Health Research Hospital, Yeni Etlik Caddesi No:55, Etlik, Keçiören, 06010 Ankara, Turkey.

ABSTRACT
Purpose. To evaluate the repeatability of measurement of central corneal thickness (CCT) by spectral domain optical coherence (SD-OCT) in premature infants and compare it to CCT measurement by ultrasonic pachymetry (USP). Methods. Three CCT measurements of the left eyes of 50 premature infants were obtained by SD-OCT using the iVue system. 10 CCT measurements of each 28 left eyes of 28 infants were obtained by USP using the Pacscan 300P system. Bland-Altman plots were developed and the limit of agreement (LoA) was determined to compare the mean of the SD-OCT and USP measurements. Results. No statistically significant difference was found among the 3 CCT measurements by SD-OCT. Both USP and SD-OCT have been performed for only left eyes of 28 of the 50 babies. Those results have been compared with each other. A statistically significant difference was found between the mean CCT measurements by SD-OCT and USP (p < 0.05). The LoA between the SD-OCT and USP measurements ranged from 11.4 to -64.1. Conclusions. CCT can be measured using the iVue SD-OCT system with a high level of repeatability. Although measurement of CCT by SD-OCT and USP is highly correlated, the 2 systems cannot be used interchangeably in premature infants.

No MeSH data available.


Measurement of CCT by SD-OCT in a premature infant.
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fig1: Measurement of CCT by SD-OCT in a premature infant.

Mentions: The use of the iStand (Optovue Inc.), a rolling floor stand option for the iVue SDOCT system, allows patients to be scanned in various positions, including the supine position. Before examination the iVue system was mounted to the iStand to obtain images from the infant in the supine position. A drop of 0.5% proparacaine HCl solution (Alcaine; Alcon Laboratories, Fort Worth, TX, USA) was applied for topical anesthesia. No additional anesthetic or sedative drug was used. If needed, a pacifier dipped in 30% dextrose was used to calm the infant. A lid speculum was used to hold the eyelids open. A lubricant eye drop (Systane, Alcon Pharmaceuticals Ltd., Barcelona, Spain) was instilled for hydrating the cornea as necessary. During scanning, the hands of the supine-positioned infant were held by a nurse (Figure 1). Using the iVue system in the corneal pachymetry mode, in which the pupil is in the center of the small diameter circle at the screen of the computer connected to the device, three different measurements were obtained from the left eye. If the image quality was less than the manufacturer's suggested quality and/or the pupil was not centralized, the measurement was repeated after the infant had been repositioned.


Comparison of Measurement of Central Corneal Thickness with Spectral Domain Optical Coherence Tomography and Standard Ultrasonic Pachymeter in Premature Infants.

Hekimoglu E, Erol MK, Toslak D, Turgut Coban D, Doğan B, Yucel O - J Ophthalmol (2015)

Measurement of CCT by SD-OCT in a premature infant.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4525755&req=5

fig1: Measurement of CCT by SD-OCT in a premature infant.
Mentions: The use of the iStand (Optovue Inc.), a rolling floor stand option for the iVue SDOCT system, allows patients to be scanned in various positions, including the supine position. Before examination the iVue system was mounted to the iStand to obtain images from the infant in the supine position. A drop of 0.5% proparacaine HCl solution (Alcaine; Alcon Laboratories, Fort Worth, TX, USA) was applied for topical anesthesia. No additional anesthetic or sedative drug was used. If needed, a pacifier dipped in 30% dextrose was used to calm the infant. A lid speculum was used to hold the eyelids open. A lubricant eye drop (Systane, Alcon Pharmaceuticals Ltd., Barcelona, Spain) was instilled for hydrating the cornea as necessary. During scanning, the hands of the supine-positioned infant were held by a nurse (Figure 1). Using the iVue system in the corneal pachymetry mode, in which the pupil is in the center of the small diameter circle at the screen of the computer connected to the device, three different measurements were obtained from the left eye. If the image quality was less than the manufacturer's suggested quality and/or the pupil was not centralized, the measurement was repeated after the infant had been repositioned.

Bottom Line: No statistically significant difference was found among the 3 CCT measurements by SD-OCT.Those results have been compared with each other.A statistically significant difference was found between the mean CCT measurements by SD-OCT and USP (p < 0.05).

View Article: PubMed Central - PubMed

Affiliation: Ophthalmology Department, Etlik Zubeyde Hanim Maternity and Women's Health Research Hospital, Yeni Etlik Caddesi No:55, Etlik, Keçiören, 06010 Ankara, Turkey.

ABSTRACT
Purpose. To evaluate the repeatability of measurement of central corneal thickness (CCT) by spectral domain optical coherence (SD-OCT) in premature infants and compare it to CCT measurement by ultrasonic pachymetry (USP). Methods. Three CCT measurements of the left eyes of 50 premature infants were obtained by SD-OCT using the iVue system. 10 CCT measurements of each 28 left eyes of 28 infants were obtained by USP using the Pacscan 300P system. Bland-Altman plots were developed and the limit of agreement (LoA) was determined to compare the mean of the SD-OCT and USP measurements. Results. No statistically significant difference was found among the 3 CCT measurements by SD-OCT. Both USP and SD-OCT have been performed for only left eyes of 28 of the 50 babies. Those results have been compared with each other. A statistically significant difference was found between the mean CCT measurements by SD-OCT and USP (p < 0.05). The LoA between the SD-OCT and USP measurements ranged from 11.4 to -64.1. Conclusions. CCT can be measured using the iVue SD-OCT system with a high level of repeatability. Although measurement of CCT by SD-OCT and USP is highly correlated, the 2 systems cannot be used interchangeably in premature infants.

No MeSH data available.