Limits...
Prevalence of different comorbidities in COPD patients by gender and GOLD stage.

Dal Negro RW, Bonadiman L, Turco P - Multidiscip Respir Med (2015)

Bottom Line: As concerning respiratory disorders, pneumonia, pleural effusions and chronic respiratory failure were more frequently found in men, while bronchiectasis and asthma-COPD overlap syndrome (ACOS) in females.Cognition disorders, dementia and signs of degenerative brain disorders were more frequently found in men, while depression in females.The gender-dependency of comorbidities was confirmed in general terms, even if lung cancer proved a dramatic increase almost independently of sex.

View Article: PubMed Central - PubMed

Affiliation: National Centre for Respiratory Pharmacoeconomics and Pharmacoepidemiology, CESFAR, Verona, Italy ; CEMS, Specialist Medical Centre, Verona, Italy.

ABSTRACT

Background: Several comorbidities frequently affect COPD progression. Aim of the study was to assess the prevalence of main comorbidities by gender and disease severity in a cohort of COPD patients referring for the first time to a specialist institution.

Methods: The study was a non-interventional, cross-sectional investigation carried out via automatic and anonymous selection from the institutional data base over the period 2012-2015. Inclusion criteria were: subjects of both sex aged ≥40 years; diagnosis of COPD according to GOLD guidelines 2014; the availability of a complete clinical record file. Variables collected were: lung function; smoking history; BMI; the Charlson Comorbidity Index (CCI); number and kind of comorbidities for each patient.

Results: At least one comorbidity of clinical relevance was found in 78.6 % of patients, but at least two in 68.8 %, and three or more were found in 47.9 % of subjects. Mean CCI was 3.4 ± 1.6sd. The overall prevalence was 2.6 comorbidities per patient, but 2.5 in males, and 3.0 in females, respectively (p < 0.05). Cardio-vascular disorders were the most frequent, but significantly more frequent in males (44.7 vs 30.7 %, respectively), while the metabolic, the digestive and the osteo-articular disorders were prevailing in females (12.4 vs 9.2; 14.2 vs 4.8, and 6.0 vs 3.8, respectively). In particular, chronic cor pumonale and arrhythmias mainly prevailed in men and congestive heart failure in females, while arterial hypertension resulted equally distributed. As concerning respiratory disorders, pneumonia, pleural effusions and chronic respiratory failure were more frequently found in men, while bronchiectasis and asthma-COPD overlap syndrome (ACOS) in females. Anaemia, gall bladder stones, osteoporosis and spontaneous fractures mostly prevailed in females, while gastric disorders of inflammatory origin and arthrosis were more frequent in males. Cognition disorders, dementia and signs of degenerative brain disorders were more frequently found in men, while depression in females. Finally, lung cancer was at the first place in men, but at the second in females.

Conclusions: All comorbidities increased their prevalence progressively up to the last stage of COPD severity, except the cardio-vascular and the metabolic ones which dropped in the IV GOLD stage, presumably due to the high mortality rate in this severe COPD stage. The gender-dependency of comorbidities was confirmed in general terms, even if lung cancer proved a dramatic increase almost independently of sex.

No MeSH data available.


Related in: MedlinePlus

% prevalence of different oncologic disorders by gender: Lu, lung; LA, larynx; CO, colon; ST, stomach; TY, Tyroid; KI, kidney; other
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC4525744&req=5

Fig4: % prevalence of different oncologic disorders by gender: Lu, lung; LA, larynx; CO, colon; ST, stomach; TY, Tyroid; KI, kidney; other

Mentions: Lung cancer was the most prevalent oncologic disease in men, followed by the cancer of colon and of larynx. On the other hand, lung cancer was the second most frequent cancer in females, only preceded by the thyroid cancer. Moreover, as concerning the gender-specific oncologic diseases, the prostate cancer in males, and those of the breast and of the gynecological district in females were the most frequent, respectively (Figs. 4 and 5).Fig. 4


Prevalence of different comorbidities in COPD patients by gender and GOLD stage.

Dal Negro RW, Bonadiman L, Turco P - Multidiscip Respir Med (2015)

% prevalence of different oncologic disorders by gender: Lu, lung; LA, larynx; CO, colon; ST, stomach; TY, Tyroid; KI, kidney; other
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4525744&req=5

Fig4: % prevalence of different oncologic disorders by gender: Lu, lung; LA, larynx; CO, colon; ST, stomach; TY, Tyroid; KI, kidney; other
Mentions: Lung cancer was the most prevalent oncologic disease in men, followed by the cancer of colon and of larynx. On the other hand, lung cancer was the second most frequent cancer in females, only preceded by the thyroid cancer. Moreover, as concerning the gender-specific oncologic diseases, the prostate cancer in males, and those of the breast and of the gynecological district in females were the most frequent, respectively (Figs. 4 and 5).Fig. 4

Bottom Line: As concerning respiratory disorders, pneumonia, pleural effusions and chronic respiratory failure were more frequently found in men, while bronchiectasis and asthma-COPD overlap syndrome (ACOS) in females.Cognition disorders, dementia and signs of degenerative brain disorders were more frequently found in men, while depression in females.The gender-dependency of comorbidities was confirmed in general terms, even if lung cancer proved a dramatic increase almost independently of sex.

View Article: PubMed Central - PubMed

Affiliation: National Centre for Respiratory Pharmacoeconomics and Pharmacoepidemiology, CESFAR, Verona, Italy ; CEMS, Specialist Medical Centre, Verona, Italy.

ABSTRACT

Background: Several comorbidities frequently affect COPD progression. Aim of the study was to assess the prevalence of main comorbidities by gender and disease severity in a cohort of COPD patients referring for the first time to a specialist institution.

Methods: The study was a non-interventional, cross-sectional investigation carried out via automatic and anonymous selection from the institutional data base over the period 2012-2015. Inclusion criteria were: subjects of both sex aged ≥40 years; diagnosis of COPD according to GOLD guidelines 2014; the availability of a complete clinical record file. Variables collected were: lung function; smoking history; BMI; the Charlson Comorbidity Index (CCI); number and kind of comorbidities for each patient.

Results: At least one comorbidity of clinical relevance was found in 78.6 % of patients, but at least two in 68.8 %, and three or more were found in 47.9 % of subjects. Mean CCI was 3.4 ± 1.6sd. The overall prevalence was 2.6 comorbidities per patient, but 2.5 in males, and 3.0 in females, respectively (p < 0.05). Cardio-vascular disorders were the most frequent, but significantly more frequent in males (44.7 vs 30.7 %, respectively), while the metabolic, the digestive and the osteo-articular disorders were prevailing in females (12.4 vs 9.2; 14.2 vs 4.8, and 6.0 vs 3.8, respectively). In particular, chronic cor pumonale and arrhythmias mainly prevailed in men and congestive heart failure in females, while arterial hypertension resulted equally distributed. As concerning respiratory disorders, pneumonia, pleural effusions and chronic respiratory failure were more frequently found in men, while bronchiectasis and asthma-COPD overlap syndrome (ACOS) in females. Anaemia, gall bladder stones, osteoporosis and spontaneous fractures mostly prevailed in females, while gastric disorders of inflammatory origin and arthrosis were more frequent in males. Cognition disorders, dementia and signs of degenerative brain disorders were more frequently found in men, while depression in females. Finally, lung cancer was at the first place in men, but at the second in females.

Conclusions: All comorbidities increased their prevalence progressively up to the last stage of COPD severity, except the cardio-vascular and the metabolic ones which dropped in the IV GOLD stage, presumably due to the high mortality rate in this severe COPD stage. The gender-dependency of comorbidities was confirmed in general terms, even if lung cancer proved a dramatic increase almost independently of sex.

No MeSH data available.


Related in: MedlinePlus