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Primary Peritoneal Mesothelioma Resulting in Small Bowel Obstruction: A Case Report and Review of Literature.

Frontario SC, Loveitt A, Goldenberg-Sandau A, Liu J, Roy D, Cohen LW - Am J Case Rep (2015)

Bottom Line: The patient had multiple risk factors with asbestos exposure and prior therapeutic radiation.However, there are other non-asbestos etiologies.Small bowel obstruction often is a late-presenting symptom of widespread tumor burden.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Rowan University School of Osteopathic Medicine, Stratford, NJ, USA.

ABSTRACT

Background: Peritoneal mesothelioma is a rare malignancy that affects the serosal surfaces of the peritoneum. The peritoneum is the second most common site of mesothelium affected following the pleura. The aggressive nature and vague presentation pose many obstacles in not only diagnosis but also the treatment of patients with this disease.

Case report: We present a case of a 76-year-old woman who presented with small bowel obstruction secondary to carcinomatosis secondary to primary peritoneal mesothelioma. The patient had multiple risk factors with asbestos exposure and prior therapeutic radiation.

Conclusions: We discuss the highly varied and elusive presentation of peritoneal mesothelioma. Cumulative asbestos exposure, either directly or indirectly, remains the leading cause of mesothelioma. However, there are other non-asbestos etiologies. Small bowel obstruction often is a late-presenting symptom of widespread tumor burden. A concise review of the current diagnostic and surgical treatment of primary peritoneal mesothelioma demonstrates that early diagnosis and implementation remains vital.

No MeSH data available.


Related in: MedlinePlus

Mesothelial origin of the cells is demonstrated by positive immunohistochemical stain of calretinin.
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Related In: Results  -  Collection


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f3-amjcaserep-16-496: Mesothelial origin of the cells is demonstrated by positive immunohistochemical stain of calretinin.

Mentions: Immunohistochemical stains demonstrated cells positive for calretinin, CK5/6, CK7, WT1 and negative for CK20, CEA, MOC-31(Figures 3–5). After 2 days of conservative management with nasogastric tube, there was no resolution of the small bowel obstruction, with persistent symptoms of nausea and abdominal distention. The patient was taken to the operating room for an exploratory laparotomy. Upon exploration, diffuse ascites was encountered throughout the abdomen.


Primary Peritoneal Mesothelioma Resulting in Small Bowel Obstruction: A Case Report and Review of Literature.

Frontario SC, Loveitt A, Goldenberg-Sandau A, Liu J, Roy D, Cohen LW - Am J Case Rep (2015)

Mesothelial origin of the cells is demonstrated by positive immunohistochemical stain of calretinin.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4525679&req=5

f3-amjcaserep-16-496: Mesothelial origin of the cells is demonstrated by positive immunohistochemical stain of calretinin.
Mentions: Immunohistochemical stains demonstrated cells positive for calretinin, CK5/6, CK7, WT1 and negative for CK20, CEA, MOC-31(Figures 3–5). After 2 days of conservative management with nasogastric tube, there was no resolution of the small bowel obstruction, with persistent symptoms of nausea and abdominal distention. The patient was taken to the operating room for an exploratory laparotomy. Upon exploration, diffuse ascites was encountered throughout the abdomen.

Bottom Line: The patient had multiple risk factors with asbestos exposure and prior therapeutic radiation.However, there are other non-asbestos etiologies.Small bowel obstruction often is a late-presenting symptom of widespread tumor burden.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Rowan University School of Osteopathic Medicine, Stratford, NJ, USA.

ABSTRACT

Background: Peritoneal mesothelioma is a rare malignancy that affects the serosal surfaces of the peritoneum. The peritoneum is the second most common site of mesothelium affected following the pleura. The aggressive nature and vague presentation pose many obstacles in not only diagnosis but also the treatment of patients with this disease.

Case report: We present a case of a 76-year-old woman who presented with small bowel obstruction secondary to carcinomatosis secondary to primary peritoneal mesothelioma. The patient had multiple risk factors with asbestos exposure and prior therapeutic radiation.

Conclusions: We discuss the highly varied and elusive presentation of peritoneal mesothelioma. Cumulative asbestos exposure, either directly or indirectly, remains the leading cause of mesothelioma. However, there are other non-asbestos etiologies. Small bowel obstruction often is a late-presenting symptom of widespread tumor burden. A concise review of the current diagnostic and surgical treatment of primary peritoneal mesothelioma demonstrates that early diagnosis and implementation remains vital.

No MeSH data available.


Related in: MedlinePlus