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Toward the modeling of mucus draining from human lung: role of airways deformation on air-mucus interaction.

Mauroy B, Flaud P, Pelca D, Fausser C, Merckx J, Mitchell BR - Front Physiol (2015)

Bottom Line: Moreover, the higher the pressure or the quicker it is applied, the higher is the air flow and thus the mobilization of secretions.Generally, the first effects of manipulations is a decrease of the airway tree hydrodynamic resistance, thus improving ventilation even if secretions do not get out of the lungs.Finally, we propose and tested two a dimensional numbers that depend on lung properties and that allow to measure the efficiency and comfort of a manipulation.

View Article: PubMed Central - PubMed

Affiliation: Laboratoire J. A. Dieudonnée - UMR CNRS 7351, Université de Nice-Sophia Antipolis Nice, France.

ABSTRACT
Chest physiotherapy is an empirical technique used to help secretions to get out of the lung whenever stagnation occurs. Although commonly used, little is known about the inner mechanisms of chest physiotherapy and controversies about its use are coming out regularly. Thus, a scientific validation of chest physiotherapy is needed to evaluate its effects on secretions. We setup a quasi-static numerical model of chest physiotherapy based on thorax and lung physiology and on their respective biophysics. We modeled the lung with an idealized deformable symmetric bifurcating tree. Bronchi and their inner fluids mechanics are assumed axisymmetric. Static data from the literature is used to build a model for the lung's mechanics. Secretions motion is the consequence of the shear constraints apply by the air flow. The input of the model is the pressure on the chest wall at each time, and the output is the bronchi geometry and air and secretions properties. In the limit of our model, we mimicked manual and mechanical chest physiotherapy techniques. We show that for secretions to move, air flow has to be high enough to overcome secretion resistance to motion. Moreover, the higher the pressure or the quicker it is applied, the higher is the air flow and thus the mobilization of secretions. However, pressures too high are efficient up to a point where airways compressions prevents air flow to increase any further. Generally, the first effects of manipulations is a decrease of the airway tree hydrodynamic resistance, thus improving ventilation even if secretions do not get out of the lungs. Also, some secretions might be pushed deeper into the lungs; this effect is stronger for high pressures and for mechanical chest physiotherapy. Finally, we propose and tested two a dimensional numbers that depend on lung properties and that allow to measure the efficiency and comfort of a manipulation.

No MeSH data available.


(A) Evolution of mucus distribution in the bronchi during the manipulation with Ps = 5.6 cmH2O and Po = 1.2 cmH2O. (B) Relative hydrodynamic resistance changes during a manipulation with Pcp = 20 cmH2O (blue). The red line corresponds to FRC relative hydrodynamic resistance before the manipulation (r/t = 0s = 1.00) while the black line corresponds to FRC relative hydrodynamic resistance at the end of the manipulation (r/t = 230s = 0.79).
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Figure 8: (A) Evolution of mucus distribution in the bronchi during the manipulation with Ps = 5.6 cmH2O and Po = 1.2 cmH2O. (B) Relative hydrodynamic resistance changes during a manipulation with Pcp = 20 cmH2O (blue). The red line corresponds to FRC relative hydrodynamic resistance before the manipulation (r/t = 0s = 1.00) while the black line corresponds to FRC relative hydrodynamic resistance at the end of the manipulation (r/t = 230s = 0.79).

Mentions: As for manual chest physiotherapy, our model predicts that the manipulation redistributes the secretions in the tree in such a way it reduces the hydrodynamic resistance of the tree by about 20 percents at the end of the manipulation, see Figure 8A. The manipulation efficiency is higher at the beginning and decreases with time, as shown on Figure 8B. Because the static pressure and the oscillations occurred during the whole ventilation cycle, the secretions spread a little more down the tree than for manual chest physiotherapy. Initially, mean mucus generation in the tree is 7.34, and it reaches 7.47 at the end of the manipulation, see Figure 9. With the parameters used in this section, our model predicts that no secretions are going out of the tree.


Toward the modeling of mucus draining from human lung: role of airways deformation on air-mucus interaction.

Mauroy B, Flaud P, Pelca D, Fausser C, Merckx J, Mitchell BR - Front Physiol (2015)

(A) Evolution of mucus distribution in the bronchi during the manipulation with Ps = 5.6 cmH2O and Po = 1.2 cmH2O. (B) Relative hydrodynamic resistance changes during a manipulation with Pcp = 20 cmH2O (blue). The red line corresponds to FRC relative hydrodynamic resistance before the manipulation (r/t = 0s = 1.00) while the black line corresponds to FRC relative hydrodynamic resistance at the end of the manipulation (r/t = 230s = 0.79).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4525672&req=5

Figure 8: (A) Evolution of mucus distribution in the bronchi during the manipulation with Ps = 5.6 cmH2O and Po = 1.2 cmH2O. (B) Relative hydrodynamic resistance changes during a manipulation with Pcp = 20 cmH2O (blue). The red line corresponds to FRC relative hydrodynamic resistance before the manipulation (r/t = 0s = 1.00) while the black line corresponds to FRC relative hydrodynamic resistance at the end of the manipulation (r/t = 230s = 0.79).
Mentions: As for manual chest physiotherapy, our model predicts that the manipulation redistributes the secretions in the tree in such a way it reduces the hydrodynamic resistance of the tree by about 20 percents at the end of the manipulation, see Figure 8A. The manipulation efficiency is higher at the beginning and decreases with time, as shown on Figure 8B. Because the static pressure and the oscillations occurred during the whole ventilation cycle, the secretions spread a little more down the tree than for manual chest physiotherapy. Initially, mean mucus generation in the tree is 7.34, and it reaches 7.47 at the end of the manipulation, see Figure 9. With the parameters used in this section, our model predicts that no secretions are going out of the tree.

Bottom Line: Moreover, the higher the pressure or the quicker it is applied, the higher is the air flow and thus the mobilization of secretions.Generally, the first effects of manipulations is a decrease of the airway tree hydrodynamic resistance, thus improving ventilation even if secretions do not get out of the lungs.Finally, we propose and tested two a dimensional numbers that depend on lung properties and that allow to measure the efficiency and comfort of a manipulation.

View Article: PubMed Central - PubMed

Affiliation: Laboratoire J. A. Dieudonnée - UMR CNRS 7351, Université de Nice-Sophia Antipolis Nice, France.

ABSTRACT
Chest physiotherapy is an empirical technique used to help secretions to get out of the lung whenever stagnation occurs. Although commonly used, little is known about the inner mechanisms of chest physiotherapy and controversies about its use are coming out regularly. Thus, a scientific validation of chest physiotherapy is needed to evaluate its effects on secretions. We setup a quasi-static numerical model of chest physiotherapy based on thorax and lung physiology and on their respective biophysics. We modeled the lung with an idealized deformable symmetric bifurcating tree. Bronchi and their inner fluids mechanics are assumed axisymmetric. Static data from the literature is used to build a model for the lung's mechanics. Secretions motion is the consequence of the shear constraints apply by the air flow. The input of the model is the pressure on the chest wall at each time, and the output is the bronchi geometry and air and secretions properties. In the limit of our model, we mimicked manual and mechanical chest physiotherapy techniques. We show that for secretions to move, air flow has to be high enough to overcome secretion resistance to motion. Moreover, the higher the pressure or the quicker it is applied, the higher is the air flow and thus the mobilization of secretions. However, pressures too high are efficient up to a point where airways compressions prevents air flow to increase any further. Generally, the first effects of manipulations is a decrease of the airway tree hydrodynamic resistance, thus improving ventilation even if secretions do not get out of the lungs. Also, some secretions might be pushed deeper into the lungs; this effect is stronger for high pressures and for mechanical chest physiotherapy. Finally, we propose and tested two a dimensional numbers that depend on lung properties and that allow to measure the efficiency and comfort of a manipulation.

No MeSH data available.