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Type 1 Diabetes Modifies Brain Activation in Young Patients While Performing Visuospatial Working Memory Tasks.

Gallardo-Moreno GB, González-Garrido AA, Gudayol-Ferré E, Guàrdia-Olmos J - J Diabetes Res (2015)

Bottom Line: There was no significant statistical difference in behavioral performance between the groups, but, in accordance with our hypothesis, results showed distinct brain activation patterns.Control subjects presented the expected activations related to the task, whereas the patients had greater activation in the prefrontal inferior cortex, basal ganglia, posterior cerebellum, and substantia nigra.These different patterns could be due to compensation mechanisms that allow them to maintain a behavioral performance similar to that of control subjects.

View Article: PubMed Central - PubMed

Affiliation: Instituto de Neurociencias, Universidad de Guadalajara, Francisco de Quevedo 180, Colonia Arcos Vallarta, 44130 Guadalajara, JAL, Mexico.

ABSTRACT
In recent years, increasing attention has been paid to the effects of Type 1 Diabetes (T1D) on cognitive functions. T1D onset usually occurs during childhood, so it is possible that the brain could be affected during neurodevelopment. We selected young patients of normal intelligence with T1D onset during neurodevelopment, no complications from diabetes, and adequate glycemic control. The purpose of this study was to compare the neural BOLD activation pattern in a group of patients with T1D versus healthy control subjects while performing a visuospatial working memory task. Sixteen patients and 16 matched healthy control subjects participated. There was no significant statistical difference in behavioral performance between the groups, but, in accordance with our hypothesis, results showed distinct brain activation patterns. Control subjects presented the expected activations related to the task, whereas the patients had greater activation in the prefrontal inferior cortex, basal ganglia, posterior cerebellum, and substantia nigra. These different patterns could be due to compensation mechanisms that allow them to maintain a behavioral performance similar to that of control subjects.

No MeSH data available.


Related in: MedlinePlus

Statistical parametric maps of regions of greatest activation for each condition for both groups.
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fig2: Statistical parametric maps of regions of greatest activation for each condition for both groups.

Mentions: In the first-level analyses of each subject, patients and controls showed similar activations in the bilateral parietal lobe, premotor cortex, superior frontal gyrus, and cerebellum. However, the second-level analyses showed that cluster size and activation intensity differed between groups. Brain activations in response to each condition of the visuospatial working memory task for the two groups are shown in Figure 2. The regions of greatest BOLD activation in the control group for condition A were located in the right superior and inferior parietal lobes, left premotor cortex, left superior frontal gyrus, right inferior frontal cortex, bilateral cerebellum (tonsil and pyramid), and left putamen. In the patients group, however, the main brain activations while performing condition A appeared in the right inferior and medial frontal cortex, bilateral cerebellum (i.e., parts of the tonsil, tuber, declive, pyramid, and semilunar lobule), and left putamen. The control group showed activations related to condition B in the right medial and superior frontal gyrus, bilateral superior and inferior parietal lobes, left premotor cortex, and bilateral cerebellum (tonsil and pyramid), while the patients showed cerebral activations primarily in the right inferior frontal gyrus, bilateral cerebellum (right tonsil, left tuber, and pyramid), the right putamen, medial globus pallidus, and substantia nigra in the midbrain.


Type 1 Diabetes Modifies Brain Activation in Young Patients While Performing Visuospatial Working Memory Tasks.

Gallardo-Moreno GB, González-Garrido AA, Gudayol-Ferré E, Guàrdia-Olmos J - J Diabetes Res (2015)

Statistical parametric maps of regions of greatest activation for each condition for both groups.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4525461&req=5

fig2: Statistical parametric maps of regions of greatest activation for each condition for both groups.
Mentions: In the first-level analyses of each subject, patients and controls showed similar activations in the bilateral parietal lobe, premotor cortex, superior frontal gyrus, and cerebellum. However, the second-level analyses showed that cluster size and activation intensity differed between groups. Brain activations in response to each condition of the visuospatial working memory task for the two groups are shown in Figure 2. The regions of greatest BOLD activation in the control group for condition A were located in the right superior and inferior parietal lobes, left premotor cortex, left superior frontal gyrus, right inferior frontal cortex, bilateral cerebellum (tonsil and pyramid), and left putamen. In the patients group, however, the main brain activations while performing condition A appeared in the right inferior and medial frontal cortex, bilateral cerebellum (i.e., parts of the tonsil, tuber, declive, pyramid, and semilunar lobule), and left putamen. The control group showed activations related to condition B in the right medial and superior frontal gyrus, bilateral superior and inferior parietal lobes, left premotor cortex, and bilateral cerebellum (tonsil and pyramid), while the patients showed cerebral activations primarily in the right inferior frontal gyrus, bilateral cerebellum (right tonsil, left tuber, and pyramid), the right putamen, medial globus pallidus, and substantia nigra in the midbrain.

Bottom Line: There was no significant statistical difference in behavioral performance between the groups, but, in accordance with our hypothesis, results showed distinct brain activation patterns.Control subjects presented the expected activations related to the task, whereas the patients had greater activation in the prefrontal inferior cortex, basal ganglia, posterior cerebellum, and substantia nigra.These different patterns could be due to compensation mechanisms that allow them to maintain a behavioral performance similar to that of control subjects.

View Article: PubMed Central - PubMed

Affiliation: Instituto de Neurociencias, Universidad de Guadalajara, Francisco de Quevedo 180, Colonia Arcos Vallarta, 44130 Guadalajara, JAL, Mexico.

ABSTRACT
In recent years, increasing attention has been paid to the effects of Type 1 Diabetes (T1D) on cognitive functions. T1D onset usually occurs during childhood, so it is possible that the brain could be affected during neurodevelopment. We selected young patients of normal intelligence with T1D onset during neurodevelopment, no complications from diabetes, and adequate glycemic control. The purpose of this study was to compare the neural BOLD activation pattern in a group of patients with T1D versus healthy control subjects while performing a visuospatial working memory task. Sixteen patients and 16 matched healthy control subjects participated. There was no significant statistical difference in behavioral performance between the groups, but, in accordance with our hypothesis, results showed distinct brain activation patterns. Control subjects presented the expected activations related to the task, whereas the patients had greater activation in the prefrontal inferior cortex, basal ganglia, posterior cerebellum, and substantia nigra. These different patterns could be due to compensation mechanisms that allow them to maintain a behavioral performance similar to that of control subjects.

No MeSH data available.


Related in: MedlinePlus