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Fish Oil Intake and Seizure Control in Children with Medically Resistant Epilepsy.

Reda DM, Abd-El-Fatah NK, Omar Tel-S, Darwish OA - N Am J Med Sci (2015)

Bottom Line: The study was to investigate the effect of Omega 3 polyunsaturated fatty acids (as fish oil supplementation) in reducing the frequency and severity of epileptic seizures in children with medically resistant epilepsy.The number of children who received fish oil, having 0 epileptic attacks increased from 0%, before starting the study, up to 57.1% at the end of the third month, while the improvement was minimal in the placebo group, with a significant difference in the improvement between the intervention and the control groups.There was no statistically significant difference in improvement in the severity of the seizures either between cases and control or between the beginning and the end of the study.

View Article: PubMed Central - PubMed

Affiliation: Department of Nutrition, Faculty of Medicine, High Institution of Public Health, Alexandria University, Alexandria, Egypt.

ABSTRACT

Background: There is considerable evidence which suggests that Omega 3 polyunsaturated fatty acids may have a potential use in the treatment of epilepsy.

Aim: The study was to investigate the effect of Omega 3 polyunsaturated fatty acids (as fish oil supplementation) in reducing the frequency and severity of epileptic seizures in children with medically resistant epilepsy.

Materials and methods: In the case-control study, a total of 70 children with medically resistant epilepsy underwent assessment of the frequency and severity of the epileptic attacks at baseline, after one month, two months and three months from the beginning of the study; 35 children received fish oil and the other 35 children received placebo.

Results: The number of children who received fish oil, having 0 epileptic attacks increased from 0%, before starting the study, up to 57.1% at the end of the third month, while the improvement was minimal in the placebo group, with a significant difference in the improvement between the intervention and the control groups. There was no statistically significant difference in improvement in the severity of the seizures either between cases and control or between the beginning and the end of the study.

Conclusion: Omega 3 polyunsaturated fatty acids elevated the seizure threshold in epileptic patients and may help in achieving seizure control.

No MeSH data available.


Related in: MedlinePlus

Data showing no significant decrease in the medians of the seizure severity scores, which indicates that there is no effect of the fish oil on seizure severity
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Figure 3: Data showing no significant decrease in the medians of the seizure severity scores, which indicates that there is no effect of the fish oil on seizure severity

Mentions: As to seizure severity, at baseline (one month before fish oil supplementation) a median score of 13 and 12 of the NHS3 was obtained in intervention and control group, respectively. This median decreased into 11 after one month of intervention then increased to 13 again after two months and became 10 after three months of fish oil supplementation, while it remained 12 in the control group throughout the study. So in term of the median, there is no statistically significant decrease in the monthly NHS3 score after 3 months of fish oil supplementation compared to the baseline before supplementation (P > 0.05). [Table 2, Figure 3]


Fish Oil Intake and Seizure Control in Children with Medically Resistant Epilepsy.

Reda DM, Abd-El-Fatah NK, Omar Tel-S, Darwish OA - N Am J Med Sci (2015)

Data showing no significant decrease in the medians of the seizure severity scores, which indicates that there is no effect of the fish oil on seizure severity
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4525390&req=5

Figure 3: Data showing no significant decrease in the medians of the seizure severity scores, which indicates that there is no effect of the fish oil on seizure severity
Mentions: As to seizure severity, at baseline (one month before fish oil supplementation) a median score of 13 and 12 of the NHS3 was obtained in intervention and control group, respectively. This median decreased into 11 after one month of intervention then increased to 13 again after two months and became 10 after three months of fish oil supplementation, while it remained 12 in the control group throughout the study. So in term of the median, there is no statistically significant decrease in the monthly NHS3 score after 3 months of fish oil supplementation compared to the baseline before supplementation (P > 0.05). [Table 2, Figure 3]

Bottom Line: The study was to investigate the effect of Omega 3 polyunsaturated fatty acids (as fish oil supplementation) in reducing the frequency and severity of epileptic seizures in children with medically resistant epilepsy.The number of children who received fish oil, having 0 epileptic attacks increased from 0%, before starting the study, up to 57.1% at the end of the third month, while the improvement was minimal in the placebo group, with a significant difference in the improvement between the intervention and the control groups.There was no statistically significant difference in improvement in the severity of the seizures either between cases and control or between the beginning and the end of the study.

View Article: PubMed Central - PubMed

Affiliation: Department of Nutrition, Faculty of Medicine, High Institution of Public Health, Alexandria University, Alexandria, Egypt.

ABSTRACT

Background: There is considerable evidence which suggests that Omega 3 polyunsaturated fatty acids may have a potential use in the treatment of epilepsy.

Aim: The study was to investigate the effect of Omega 3 polyunsaturated fatty acids (as fish oil supplementation) in reducing the frequency and severity of epileptic seizures in children with medically resistant epilepsy.

Materials and methods: In the case-control study, a total of 70 children with medically resistant epilepsy underwent assessment of the frequency and severity of the epileptic attacks at baseline, after one month, two months and three months from the beginning of the study; 35 children received fish oil and the other 35 children received placebo.

Results: The number of children who received fish oil, having 0 epileptic attacks increased from 0%, before starting the study, up to 57.1% at the end of the third month, while the improvement was minimal in the placebo group, with a significant difference in the improvement between the intervention and the control groups. There was no statistically significant difference in improvement in the severity of the seizures either between cases and control or between the beginning and the end of the study.

Conclusion: Omega 3 polyunsaturated fatty acids elevated the seizure threshold in epileptic patients and may help in achieving seizure control.

No MeSH data available.


Related in: MedlinePlus