Limits...
Fish Oil Intake and Seizure Control in Children with Medically Resistant Epilepsy.

Reda DM, Abd-El-Fatah NK, Omar Tel-S, Darwish OA - N Am J Med Sci (2015)

Bottom Line: The study was to investigate the effect of Omega 3 polyunsaturated fatty acids (as fish oil supplementation) in reducing the frequency and severity of epileptic seizures in children with medically resistant epilepsy.The number of children who received fish oil, having 0 epileptic attacks increased from 0%, before starting the study, up to 57.1% at the end of the third month, while the improvement was minimal in the placebo group, with a significant difference in the improvement between the intervention and the control groups.There was no statistically significant difference in improvement in the severity of the seizures either between cases and control or between the beginning and the end of the study.

View Article: PubMed Central - PubMed

Affiliation: Department of Nutrition, Faculty of Medicine, High Institution of Public Health, Alexandria University, Alexandria, Egypt.

ABSTRACT

Background: There is considerable evidence which suggests that Omega 3 polyunsaturated fatty acids may have a potential use in the treatment of epilepsy.

Aim: The study was to investigate the effect of Omega 3 polyunsaturated fatty acids (as fish oil supplementation) in reducing the frequency and severity of epileptic seizures in children with medically resistant epilepsy.

Materials and methods: In the case-control study, a total of 70 children with medically resistant epilepsy underwent assessment of the frequency and severity of the epileptic attacks at baseline, after one month, two months and three months from the beginning of the study; 35 children received fish oil and the other 35 children received placebo.

Results: The number of children who received fish oil, having 0 epileptic attacks increased from 0%, before starting the study, up to 57.1% at the end of the third month, while the improvement was minimal in the placebo group, with a significant difference in the improvement between the intervention and the control groups. There was no statistically significant difference in improvement in the severity of the seizures either between cases and control or between the beginning and the end of the study.

Conclusion: Omega 3 polyunsaturated fatty acids elevated the seizure threshold in epileptic patients and may help in achieving seizure control.

No MeSH data available.


Related in: MedlinePlus

Data showing the difference in the frequency of epileptic attacks per month (A/M) between patients receiving fish oil and patients receiving placebo. There is significant improvement in the response of the fish oil group (P = 0.0)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4525390&req=5

Figure 2: Data showing the difference in the frequency of epileptic attacks per month (A/M) between patients receiving fish oil and patients receiving placebo. There is significant improvement in the response of the fish oil group (P = 0.0)

Mentions: Table 1 and Figure 2 compare the distribution of children according to the number of seizure attacks per month, before the intervention, after one month, after two months, and after three months of the study. In the intervention group, it is quite obvious that the cases are significantly improving and the number of epileptic attacks per month is decreasing after starting the fish oil supplementation. The percentage of children having zero attacks per month increased from 0% to 57.1% at the end of the third month in the intervention group, while it only reached 2.9% in the control group.


Fish Oil Intake and Seizure Control in Children with Medically Resistant Epilepsy.

Reda DM, Abd-El-Fatah NK, Omar Tel-S, Darwish OA - N Am J Med Sci (2015)

Data showing the difference in the frequency of epileptic attacks per month (A/M) between patients receiving fish oil and patients receiving placebo. There is significant improvement in the response of the fish oil group (P = 0.0)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4525390&req=5

Figure 2: Data showing the difference in the frequency of epileptic attacks per month (A/M) between patients receiving fish oil and patients receiving placebo. There is significant improvement in the response of the fish oil group (P = 0.0)
Mentions: Table 1 and Figure 2 compare the distribution of children according to the number of seizure attacks per month, before the intervention, after one month, after two months, and after three months of the study. In the intervention group, it is quite obvious that the cases are significantly improving and the number of epileptic attacks per month is decreasing after starting the fish oil supplementation. The percentage of children having zero attacks per month increased from 0% to 57.1% at the end of the third month in the intervention group, while it only reached 2.9% in the control group.

Bottom Line: The study was to investigate the effect of Omega 3 polyunsaturated fatty acids (as fish oil supplementation) in reducing the frequency and severity of epileptic seizures in children with medically resistant epilepsy.The number of children who received fish oil, having 0 epileptic attacks increased from 0%, before starting the study, up to 57.1% at the end of the third month, while the improvement was minimal in the placebo group, with a significant difference in the improvement between the intervention and the control groups.There was no statistically significant difference in improvement in the severity of the seizures either between cases and control or between the beginning and the end of the study.

View Article: PubMed Central - PubMed

Affiliation: Department of Nutrition, Faculty of Medicine, High Institution of Public Health, Alexandria University, Alexandria, Egypt.

ABSTRACT

Background: There is considerable evidence which suggests that Omega 3 polyunsaturated fatty acids may have a potential use in the treatment of epilepsy.

Aim: The study was to investigate the effect of Omega 3 polyunsaturated fatty acids (as fish oil supplementation) in reducing the frequency and severity of epileptic seizures in children with medically resistant epilepsy.

Materials and methods: In the case-control study, a total of 70 children with medically resistant epilepsy underwent assessment of the frequency and severity of the epileptic attacks at baseline, after one month, two months and three months from the beginning of the study; 35 children received fish oil and the other 35 children received placebo.

Results: The number of children who received fish oil, having 0 epileptic attacks increased from 0%, before starting the study, up to 57.1% at the end of the third month, while the improvement was minimal in the placebo group, with a significant difference in the improvement between the intervention and the control groups. There was no statistically significant difference in improvement in the severity of the seizures either between cases and control or between the beginning and the end of the study.

Conclusion: Omega 3 polyunsaturated fatty acids elevated the seizure threshold in epileptic patients and may help in achieving seizure control.

No MeSH data available.


Related in: MedlinePlus