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Fish Oil Intake and Seizure Control in Children with Medically Resistant Epilepsy.

Reda DM, Abd-El-Fatah NK, Omar Tel-S, Darwish OA - N Am J Med Sci (2015)

Bottom Line: The study was to investigate the effect of Omega 3 polyunsaturated fatty acids (as fish oil supplementation) in reducing the frequency and severity of epileptic seizures in children with medically resistant epilepsy.The number of children who received fish oil, having 0 epileptic attacks increased from 0%, before starting the study, up to 57.1% at the end of the third month, while the improvement was minimal in the placebo group, with a significant difference in the improvement between the intervention and the control groups.There was no statistically significant difference in improvement in the severity of the seizures either between cases and control or between the beginning and the end of the study.

View Article: PubMed Central - PubMed

Affiliation: Department of Nutrition, Faculty of Medicine, High Institution of Public Health, Alexandria University, Alexandria, Egypt.

ABSTRACT

Background: There is considerable evidence which suggests that Omega 3 polyunsaturated fatty acids may have a potential use in the treatment of epilepsy.

Aim: The study was to investigate the effect of Omega 3 polyunsaturated fatty acids (as fish oil supplementation) in reducing the frequency and severity of epileptic seizures in children with medically resistant epilepsy.

Materials and methods: In the case-control study, a total of 70 children with medically resistant epilepsy underwent assessment of the frequency and severity of the epileptic attacks at baseline, after one month, two months and three months from the beginning of the study; 35 children received fish oil and the other 35 children received placebo.

Results: The number of children who received fish oil, having 0 epileptic attacks increased from 0%, before starting the study, up to 57.1% at the end of the third month, while the improvement was minimal in the placebo group, with a significant difference in the improvement between the intervention and the control groups. There was no statistically significant difference in improvement in the severity of the seizures either between cases and control or between the beginning and the end of the study.

Conclusion: Omega 3 polyunsaturated fatty acids elevated the seizure threshold in epileptic patients and may help in achieving seizure control.

No MeSH data available.


Related in: MedlinePlus

Data showing the decrease in the medians of the seizure attacks per month. After one month of starting the fish oil and reaching zero after two months of supplementation
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Figure 1: Data showing the decrease in the medians of the seizure attacks per month. After one month of starting the fish oil and reaching zero after two months of supplementation

Mentions: At baseline (one month before fish oil supplementation), a median number of four seizures per month was obtained in both the intervention and the control group. This median decreased to 2 after one month and became 0 after two and three months of intervention with fish oil supplementation while it remained 4 in the control group. Therefore, there was a statistically significant decrease in the monthly number of seizures after three months of fish oil supplementation compared to the baseline before supplementation (P < 0.05). [Table 1 and Figure 1].


Fish Oil Intake and Seizure Control in Children with Medically Resistant Epilepsy.

Reda DM, Abd-El-Fatah NK, Omar Tel-S, Darwish OA - N Am J Med Sci (2015)

Data showing the decrease in the medians of the seizure attacks per month. After one month of starting the fish oil and reaching zero after two months of supplementation
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4525390&req=5

Figure 1: Data showing the decrease in the medians of the seizure attacks per month. After one month of starting the fish oil and reaching zero after two months of supplementation
Mentions: At baseline (one month before fish oil supplementation), a median number of four seizures per month was obtained in both the intervention and the control group. This median decreased to 2 after one month and became 0 after two and three months of intervention with fish oil supplementation while it remained 4 in the control group. Therefore, there was a statistically significant decrease in the monthly number of seizures after three months of fish oil supplementation compared to the baseline before supplementation (P < 0.05). [Table 1 and Figure 1].

Bottom Line: The study was to investigate the effect of Omega 3 polyunsaturated fatty acids (as fish oil supplementation) in reducing the frequency and severity of epileptic seizures in children with medically resistant epilepsy.The number of children who received fish oil, having 0 epileptic attacks increased from 0%, before starting the study, up to 57.1% at the end of the third month, while the improvement was minimal in the placebo group, with a significant difference in the improvement between the intervention and the control groups.There was no statistically significant difference in improvement in the severity of the seizures either between cases and control or between the beginning and the end of the study.

View Article: PubMed Central - PubMed

Affiliation: Department of Nutrition, Faculty of Medicine, High Institution of Public Health, Alexandria University, Alexandria, Egypt.

ABSTRACT

Background: There is considerable evidence which suggests that Omega 3 polyunsaturated fatty acids may have a potential use in the treatment of epilepsy.

Aim: The study was to investigate the effect of Omega 3 polyunsaturated fatty acids (as fish oil supplementation) in reducing the frequency and severity of epileptic seizures in children with medically resistant epilepsy.

Materials and methods: In the case-control study, a total of 70 children with medically resistant epilepsy underwent assessment of the frequency and severity of the epileptic attacks at baseline, after one month, two months and three months from the beginning of the study; 35 children received fish oil and the other 35 children received placebo.

Results: The number of children who received fish oil, having 0 epileptic attacks increased from 0%, before starting the study, up to 57.1% at the end of the third month, while the improvement was minimal in the placebo group, with a significant difference in the improvement between the intervention and the control groups. There was no statistically significant difference in improvement in the severity of the seizures either between cases and control or between the beginning and the end of the study.

Conclusion: Omega 3 polyunsaturated fatty acids elevated the seizure threshold in epileptic patients and may help in achieving seizure control.

No MeSH data available.


Related in: MedlinePlus