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miRegulome: a knowledge-base of miRNA regulomics and analysis.

Barh D, Kamapantula B, Jain N, Nalluri J, Bhattacharya A, Juneja L, Barve N, Tiwari S, Miyoshi A, Azevedo V, Blum K, Kumar A, Silva A, Ghosh P - Sci Rep (2015)

Bottom Line: The current version of miRegulome v1.0 provides details on the entire regulatory modules of miRNAs altered in response to chemical treatments and transcription factors, based on validated data manually curated from published literature.Modules of miRegulome (upstream regulators, downstream targets, miRNA regulated pathways, functions, diseases, etc) are hyperlinked to an appropriate external resource and are displayed visually to provide a comprehensive understanding.Four analysis tools are incorporated to identify relationships among different modules based on user specified datasets. miRegulome and its tools are helpful in understanding the biology of miRNAs and will also facilitate the discovery of biomarkers and therapeutics.

View Article: PubMed Central - PubMed

Affiliation: Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, WB-721172, India.

ABSTRACT

Unlabelled: miRNAs regulate post transcriptional gene expression by targeting multiple mRNAs and hence can modulate multiple signalling pathways, biological processes, and patho-physiologies. Therefore, understanding of miRNA regulatory networks is essential in order to modulate the functions of a miRNA. The focus of several existing databases is to provide information on specific aspects of miRNA regulation. However, an integrated resource on the miRNA regulome is currently not available to facilitate the exploration and understanding of miRNA regulomics. miRegulome attempts to bridge this gap. The current version of miRegulome v1.0 provides details on the entire regulatory modules of miRNAs altered in response to chemical treatments and transcription factors, based on validated data manually curated from published literature. Modules of miRegulome (upstream regulators, downstream targets, miRNA regulated pathways, functions, diseases, etc) are hyperlinked to an appropriate external resource and are displayed visually to provide a comprehensive understanding. Four analysis tools are incorporated to identify relationships among different modules based on user specified datasets. miRegulome and its tools are helpful in understanding the biology of miRNAs and will also facilitate the discovery of biomarkers and therapeutics. With added features in upcoming releases, miRegulome will be an essential resource to the scientific community.

Availability: http://bnet.egr.vcu.edu/miRegulome.

No MeSH data available.


Related in: MedlinePlus

Emerging molecular mechanism and correlation between obesity and diabetes as identified by miRegulome data.For details, please see the text.
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f5: Emerging molecular mechanism and correlation between obesity and diabetes as identified by miRegulome data.For details, please see the text.

Mentions: Similarly, we can explore complex associations among several modules and novel correlations using the “Advanced search” option. For example, it can be found that, hsa-mir-27b is down-regulated and hsa-mir-143 is up-regulated in obesity. Further, from miRegulome v1.0, it can also be established that hsa-mir-27b is involved in adipocytokine, insulin, and type-2 diabetes pathways and hsa-mir-143 acts in lipid metabolism pathway. These pathways are important events in obesity and therefore, deregulation of hsa-mir-27b and hsa-mir-143 may affect these pathways and eventually may lead to obesity and diabetes. Further, the database also provides correlation of obesity - mir-27b - Ribavirin and obesity - mir-143 - Benzo[a]pyrene. As per miRegulome v1.0, Benzo(a)pyrene and Ribavirin up-regulate mmu-mir-143 and hsa-mir-27b, respectively. It is reported that higher Body Mass Index (BMI) lowers bioavailability of Ribavirin and causes treatment failure in obese HCV patients38. On the other hand, Benzo[a]pyrene can induce obesity39. In summary, it can therefore be implicated that, (a) Benzo[a]pyrene upregulates mir-143 and affects lipid metabolism to induce obesity and (b) an aberrant expression of mir-27b may play a role in obesity-associated insulin resistance by modulating adipocytokines and Ribavirin resistance in obese patients. Similarly, it also suggests that these two miRNAs interlink obesity with diabetes at a new and deeper molecular level (Fig. 5). Therefore, miRegulome v1.0 may play an important role in exploring novel molecular mechanisms behind a disease as well as designing personalized medicine.


miRegulome: a knowledge-base of miRNA regulomics and analysis.

Barh D, Kamapantula B, Jain N, Nalluri J, Bhattacharya A, Juneja L, Barve N, Tiwari S, Miyoshi A, Azevedo V, Blum K, Kumar A, Silva A, Ghosh P - Sci Rep (2015)

Emerging molecular mechanism and correlation between obesity and diabetes as identified by miRegulome data.For details, please see the text.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4525332&req=5

f5: Emerging molecular mechanism and correlation between obesity and diabetes as identified by miRegulome data.For details, please see the text.
Mentions: Similarly, we can explore complex associations among several modules and novel correlations using the “Advanced search” option. For example, it can be found that, hsa-mir-27b is down-regulated and hsa-mir-143 is up-regulated in obesity. Further, from miRegulome v1.0, it can also be established that hsa-mir-27b is involved in adipocytokine, insulin, and type-2 diabetes pathways and hsa-mir-143 acts in lipid metabolism pathway. These pathways are important events in obesity and therefore, deregulation of hsa-mir-27b and hsa-mir-143 may affect these pathways and eventually may lead to obesity and diabetes. Further, the database also provides correlation of obesity - mir-27b - Ribavirin and obesity - mir-143 - Benzo[a]pyrene. As per miRegulome v1.0, Benzo(a)pyrene and Ribavirin up-regulate mmu-mir-143 and hsa-mir-27b, respectively. It is reported that higher Body Mass Index (BMI) lowers bioavailability of Ribavirin and causes treatment failure in obese HCV patients38. On the other hand, Benzo[a]pyrene can induce obesity39. In summary, it can therefore be implicated that, (a) Benzo[a]pyrene upregulates mir-143 and affects lipid metabolism to induce obesity and (b) an aberrant expression of mir-27b may play a role in obesity-associated insulin resistance by modulating adipocytokines and Ribavirin resistance in obese patients. Similarly, it also suggests that these two miRNAs interlink obesity with diabetes at a new and deeper molecular level (Fig. 5). Therefore, miRegulome v1.0 may play an important role in exploring novel molecular mechanisms behind a disease as well as designing personalized medicine.

Bottom Line: The current version of miRegulome v1.0 provides details on the entire regulatory modules of miRNAs altered in response to chemical treatments and transcription factors, based on validated data manually curated from published literature.Modules of miRegulome (upstream regulators, downstream targets, miRNA regulated pathways, functions, diseases, etc) are hyperlinked to an appropriate external resource and are displayed visually to provide a comprehensive understanding.Four analysis tools are incorporated to identify relationships among different modules based on user specified datasets. miRegulome and its tools are helpful in understanding the biology of miRNAs and will also facilitate the discovery of biomarkers and therapeutics.

View Article: PubMed Central - PubMed

Affiliation: Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, WB-721172, India.

ABSTRACT

Unlabelled: miRNAs regulate post transcriptional gene expression by targeting multiple mRNAs and hence can modulate multiple signalling pathways, biological processes, and patho-physiologies. Therefore, understanding of miRNA regulatory networks is essential in order to modulate the functions of a miRNA. The focus of several existing databases is to provide information on specific aspects of miRNA regulation. However, an integrated resource on the miRNA regulome is currently not available to facilitate the exploration and understanding of miRNA regulomics. miRegulome attempts to bridge this gap. The current version of miRegulome v1.0 provides details on the entire regulatory modules of miRNAs altered in response to chemical treatments and transcription factors, based on validated data manually curated from published literature. Modules of miRegulome (upstream regulators, downstream targets, miRNA regulated pathways, functions, diseases, etc) are hyperlinked to an appropriate external resource and are displayed visually to provide a comprehensive understanding. Four analysis tools are incorporated to identify relationships among different modules based on user specified datasets. miRegulome and its tools are helpful in understanding the biology of miRNAs and will also facilitate the discovery of biomarkers and therapeutics. With added features in upcoming releases, miRegulome will be an essential resource to the scientific community.

Availability: http://bnet.egr.vcu.edu/miRegulome.

No MeSH data available.


Related in: MedlinePlus