Limits...
miRegulome: a knowledge-base of miRNA regulomics and analysis.

Barh D, Kamapantula B, Jain N, Nalluri J, Bhattacharya A, Juneja L, Barve N, Tiwari S, Miyoshi A, Azevedo V, Blum K, Kumar A, Silva A, Ghosh P - Sci Rep (2015)

Bottom Line: The current version of miRegulome v1.0 provides details on the entire regulatory modules of miRNAs altered in response to chemical treatments and transcription factors, based on validated data manually curated from published literature.Modules of miRegulome (upstream regulators, downstream targets, miRNA regulated pathways, functions, diseases, etc) are hyperlinked to an appropriate external resource and are displayed visually to provide a comprehensive understanding.Four analysis tools are incorporated to identify relationships among different modules based on user specified datasets. miRegulome and its tools are helpful in understanding the biology of miRNAs and will also facilitate the discovery of biomarkers and therapeutics.

View Article: PubMed Central - PubMed

Affiliation: Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, WB-721172, India.

ABSTRACT

Unlabelled: miRNAs regulate post transcriptional gene expression by targeting multiple mRNAs and hence can modulate multiple signalling pathways, biological processes, and patho-physiologies. Therefore, understanding of miRNA regulatory networks is essential in order to modulate the functions of a miRNA. The focus of several existing databases is to provide information on specific aspects of miRNA regulation. However, an integrated resource on the miRNA regulome is currently not available to facilitate the exploration and understanding of miRNA regulomics. miRegulome attempts to bridge this gap. The current version of miRegulome v1.0 provides details on the entire regulatory modules of miRNAs altered in response to chemical treatments and transcription factors, based on validated data manually curated from published literature. Modules of miRegulome (upstream regulators, downstream targets, miRNA regulated pathways, functions, diseases, etc) are hyperlinked to an appropriate external resource and are displayed visually to provide a comprehensive understanding. Four analysis tools are incorporated to identify relationships among different modules based on user specified datasets. miRegulome and its tools are helpful in understanding the biology of miRNAs and will also facilitate the discovery of biomarkers and therapeutics. With added features in upcoming releases, miRegulome will be an essential resource to the scientific community.

Availability: http://bnet.egr.vcu.edu/miRegulome.

No MeSH data available.


Related in: MedlinePlus

Visualization of miRNA regulome in miRegulome v1.0.The figure represents hsa-miR-200b regulome.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4525332&req=5

f3: Visualization of miRNA regulome in miRegulome v1.0.The figure represents hsa-miR-200b regulome.

Mentions: In order to represent the regulome of a miRNA, we developed an intuitive schematic visualization interface. Upon selection of a miRNA (under “miRNA Details” tab), the entire regulome of the selected miRNA will be visualized below the first table (Fig. 3). The schematic visualization provides the entire regulome of the miRNA with all its modules (chemicals, upstream activators and repressors, validated targets, enriched top targets, pathways, functions, and diseases) and their relationships with the miRNA. The relative impacts (activation, inhibition or association) of these modules on the miRNA are also graphically represented. JavaScript, HTML, and CSS are used to develop this complex interaction map in an intuitive way that is easy to interpret. This component is in addition to displaying the miRNA regulome information in a tabular format for better understanding of the miRNA regulome.


miRegulome: a knowledge-base of miRNA regulomics and analysis.

Barh D, Kamapantula B, Jain N, Nalluri J, Bhattacharya A, Juneja L, Barve N, Tiwari S, Miyoshi A, Azevedo V, Blum K, Kumar A, Silva A, Ghosh P - Sci Rep (2015)

Visualization of miRNA regulome in miRegulome v1.0.The figure represents hsa-miR-200b regulome.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4525332&req=5

f3: Visualization of miRNA regulome in miRegulome v1.0.The figure represents hsa-miR-200b regulome.
Mentions: In order to represent the regulome of a miRNA, we developed an intuitive schematic visualization interface. Upon selection of a miRNA (under “miRNA Details” tab), the entire regulome of the selected miRNA will be visualized below the first table (Fig. 3). The schematic visualization provides the entire regulome of the miRNA with all its modules (chemicals, upstream activators and repressors, validated targets, enriched top targets, pathways, functions, and diseases) and their relationships with the miRNA. The relative impacts (activation, inhibition or association) of these modules on the miRNA are also graphically represented. JavaScript, HTML, and CSS are used to develop this complex interaction map in an intuitive way that is easy to interpret. This component is in addition to displaying the miRNA regulome information in a tabular format for better understanding of the miRNA regulome.

Bottom Line: The current version of miRegulome v1.0 provides details on the entire regulatory modules of miRNAs altered in response to chemical treatments and transcription factors, based on validated data manually curated from published literature.Modules of miRegulome (upstream regulators, downstream targets, miRNA regulated pathways, functions, diseases, etc) are hyperlinked to an appropriate external resource and are displayed visually to provide a comprehensive understanding.Four analysis tools are incorporated to identify relationships among different modules based on user specified datasets. miRegulome and its tools are helpful in understanding the biology of miRNAs and will also facilitate the discovery of biomarkers and therapeutics.

View Article: PubMed Central - PubMed

Affiliation: Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, WB-721172, India.

ABSTRACT

Unlabelled: miRNAs regulate post transcriptional gene expression by targeting multiple mRNAs and hence can modulate multiple signalling pathways, biological processes, and patho-physiologies. Therefore, understanding of miRNA regulatory networks is essential in order to modulate the functions of a miRNA. The focus of several existing databases is to provide information on specific aspects of miRNA regulation. However, an integrated resource on the miRNA regulome is currently not available to facilitate the exploration and understanding of miRNA regulomics. miRegulome attempts to bridge this gap. The current version of miRegulome v1.0 provides details on the entire regulatory modules of miRNAs altered in response to chemical treatments and transcription factors, based on validated data manually curated from published literature. Modules of miRegulome (upstream regulators, downstream targets, miRNA regulated pathways, functions, diseases, etc) are hyperlinked to an appropriate external resource and are displayed visually to provide a comprehensive understanding. Four analysis tools are incorporated to identify relationships among different modules based on user specified datasets. miRegulome and its tools are helpful in understanding the biology of miRNAs and will also facilitate the discovery of biomarkers and therapeutics. With added features in upcoming releases, miRegulome will be an essential resource to the scientific community.

Availability: http://bnet.egr.vcu.edu/miRegulome.

No MeSH data available.


Related in: MedlinePlus