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Disease Comorbidity Network Guides the Detection of Molecular Evidence for the Link Between Colorectal Cancer and Obesity.

Chen Y, Li L, Xu R - AMIA Jt Summits Transl Sci Proc (2015)

Bottom Line: We constructed a comorbidity network based on mining health data for millions of patients.Our approach was able to prioritize metabolic syndrome and diabetes, which are known to be associated with obesity and CRC through insulin resistance pathways.Interestingly, we found that osteoporosis was highly associated with the connection between obesity and CRC.

View Article: PubMed Central - PubMed

Affiliation: Division of Medical Informatics, Department of EECS Case Western Reserve University Cleveland, Ohio, USA, yxc233@case.edu.

ABSTRACT
Epidemiological studies suggested that obesity increases the risk of colorectal cancer (CRC). The genetic connection between CRC and obesity is multifactorial and inconclusive. In this study, we hypothesize that the study of shared comorbid diseases between CRC and obesity can offer unique insights into common genetic basis of these two diseases. We constructed a comorbidity network based on mining health data for millions of patients. We developed a novel approach and extracted the diseases that play critical roles in connecting obesity and CRC in the comorbidity network. Our approach was able to prioritize metabolic syndrome and diabetes, which are known to be associated with obesity and CRC through insulin resistance pathways. Interestingly, we found that osteoporosis was highly associated with the connection between obesity and CRC. Through gene expression meta-analysis, we identified novel genes shared among CRC, obesity and osteoporosis. Literature evidences support that these genes may contribute in explaining the genetic overlaps between obesity and CRC.

No MeSH data available.


Related in: MedlinePlus

The local network that contains all paths from obesity to colorectal cancer in the comorbidity network.
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f3-2092390: The local network that contains all paths from obesity to colorectal cancer in the comorbidity network.

Mentions: We extracted 7006 comorbidity association rules with the confidence larger than 50% from the patient records across ten years. The comorbidity network based on these rules contains 771 nodes and 15,667 edges. Fig. 3 shows the local network consisting of all the 119 paths (no longer than four steps) from obesity to CRC. A total of 24 nodes in the local network are the candidate diseases, which have associations with both obesity and CRC, and may indicate different aspects of the relationship between the two diseases.


Disease Comorbidity Network Guides the Detection of Molecular Evidence for the Link Between Colorectal Cancer and Obesity.

Chen Y, Li L, Xu R - AMIA Jt Summits Transl Sci Proc (2015)

The local network that contains all paths from obesity to colorectal cancer in the comorbidity network.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4525229&req=5

f3-2092390: The local network that contains all paths from obesity to colorectal cancer in the comorbidity network.
Mentions: We extracted 7006 comorbidity association rules with the confidence larger than 50% from the patient records across ten years. The comorbidity network based on these rules contains 771 nodes and 15,667 edges. Fig. 3 shows the local network consisting of all the 119 paths (no longer than four steps) from obesity to CRC. A total of 24 nodes in the local network are the candidate diseases, which have associations with both obesity and CRC, and may indicate different aspects of the relationship between the two diseases.

Bottom Line: We constructed a comorbidity network based on mining health data for millions of patients.Our approach was able to prioritize metabolic syndrome and diabetes, which are known to be associated with obesity and CRC through insulin resistance pathways.Interestingly, we found that osteoporosis was highly associated with the connection between obesity and CRC.

View Article: PubMed Central - PubMed

Affiliation: Division of Medical Informatics, Department of EECS Case Western Reserve University Cleveland, Ohio, USA, yxc233@case.edu.

ABSTRACT
Epidemiological studies suggested that obesity increases the risk of colorectal cancer (CRC). The genetic connection between CRC and obesity is multifactorial and inconclusive. In this study, we hypothesize that the study of shared comorbid diseases between CRC and obesity can offer unique insights into common genetic basis of these two diseases. We constructed a comorbidity network based on mining health data for millions of patients. We developed a novel approach and extracted the diseases that play critical roles in connecting obesity and CRC in the comorbidity network. Our approach was able to prioritize metabolic syndrome and diabetes, which are known to be associated with obesity and CRC through insulin resistance pathways. Interestingly, we found that osteoporosis was highly associated with the connection between obesity and CRC. Through gene expression meta-analysis, we identified novel genes shared among CRC, obesity and osteoporosis. Literature evidences support that these genes may contribute in explaining the genetic overlaps between obesity and CRC.

No MeSH data available.


Related in: MedlinePlus