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Barnidipine or Lercanidipine on Echocardiographic Parameters in Hypertensive, Type 2 Diabetics with Left Ventricular Hypertrophy: A Randomized Clinical Trial.

Derosa G, Mugellini A, Querci F, Franzetti I, Pesce RM, D'Angelo A, Maffioli P - Sci Rep (2015)

Bottom Line: Both lercanidipine and barnidipine decreased blood pressure.Interventricular septal thickness in diastole was reduced by barnidipine + losartan.Posterior wall thickness in diastole was decreased by both treatments, even if barnidipine + losartan were more effective.

View Article: PubMed Central - PubMed

Affiliation: 1] Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy [2] Center for the Study of Endocrine-Metabolic Pathophysiology and Clinical Research, University of Pavia, Pavia, Italy [3] Laboratory of Molecular Medicine, University of Pavia, Pavia, Italy.

ABSTRACT
The aim of this study was to evaluate the effects of lercanidipine or barnidipine on echocardiographic parameters, in hypertensive, type 2 diabetics with left ventricular hypertrophy. One hundred and forty-four patients were randomized to lercanidipine, 20 mg/day, or barnidipine, 20 mg/day, in addition to losartan, 100 mg/day, for 6 months. We evaluated: blood pressure, fasting plasma glucose (FPG), glycated hemoglobin (HbA(1c)), lipid profile, creatinine, estimated glomerular filtration rate (eGFR), sodium, potassium, and acid uric. Echocardiography was performed at baseline and after 6 months. Both lercanidipine and barnidipine decreased blood pressure. Left ventricular mass index was reduced to a greater extent with barnidipine + losartan. Interventricular septal thickness in diastole was reduced by barnidipine + losartan. Posterior wall thickness in diastole was decreased by both treatments, even if barnidipine + losartan were more effective. Ratio of peak early diastolic filling velocity to peak filling velocity at atrial contraction was increased by barnidipine + losartan, but not by lercanidipine + losartan. Finally, isovolumetric relaxation and time and left atrial volume index were reduced by barnidipine + losartan, while lercanidipine + losartan did not affect them. In conclusion, barnidipine + losartan provided a greater improvement of echocardiographic parameters compared to lercanidipine + losartan.

No MeSH data available.


Related in: MedlinePlus

*p < 0.001 vs baseline.SBP: systolic blood pressure; DPB: diastolic blood pressure.
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f1: *p < 0.001 vs baseline.SBP: systolic blood pressure; DPB: diastolic blood pressure.

Mentions: Both lercanidipine and barnidipine induced a similar, significant SBP and DBP reduction (p < 0.001 vs baseline for both), with no statistically significant differences between the two groups (Fig. 1).


Barnidipine or Lercanidipine on Echocardiographic Parameters in Hypertensive, Type 2 Diabetics with Left Ventricular Hypertrophy: A Randomized Clinical Trial.

Derosa G, Mugellini A, Querci F, Franzetti I, Pesce RM, D'Angelo A, Maffioli P - Sci Rep (2015)

*p < 0.001 vs baseline.SBP: systolic blood pressure; DPB: diastolic blood pressure.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4525144&req=5

f1: *p < 0.001 vs baseline.SBP: systolic blood pressure; DPB: diastolic blood pressure.
Mentions: Both lercanidipine and barnidipine induced a similar, significant SBP and DBP reduction (p < 0.001 vs baseline for both), with no statistically significant differences between the two groups (Fig. 1).

Bottom Line: Both lercanidipine and barnidipine decreased blood pressure.Interventricular septal thickness in diastole was reduced by barnidipine + losartan.Posterior wall thickness in diastole was decreased by both treatments, even if barnidipine + losartan were more effective.

View Article: PubMed Central - PubMed

Affiliation: 1] Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy [2] Center for the Study of Endocrine-Metabolic Pathophysiology and Clinical Research, University of Pavia, Pavia, Italy [3] Laboratory of Molecular Medicine, University of Pavia, Pavia, Italy.

ABSTRACT
The aim of this study was to evaluate the effects of lercanidipine or barnidipine on echocardiographic parameters, in hypertensive, type 2 diabetics with left ventricular hypertrophy. One hundred and forty-four patients were randomized to lercanidipine, 20 mg/day, or barnidipine, 20 mg/day, in addition to losartan, 100 mg/day, for 6 months. We evaluated: blood pressure, fasting plasma glucose (FPG), glycated hemoglobin (HbA(1c)), lipid profile, creatinine, estimated glomerular filtration rate (eGFR), sodium, potassium, and acid uric. Echocardiography was performed at baseline and after 6 months. Both lercanidipine and barnidipine decreased blood pressure. Left ventricular mass index was reduced to a greater extent with barnidipine + losartan. Interventricular septal thickness in diastole was reduced by barnidipine + losartan. Posterior wall thickness in diastole was decreased by both treatments, even if barnidipine + losartan were more effective. Ratio of peak early diastolic filling velocity to peak filling velocity at atrial contraction was increased by barnidipine + losartan, but not by lercanidipine + losartan. Finally, isovolumetric relaxation and time and left atrial volume index were reduced by barnidipine + losartan, while lercanidipine + losartan did not affect them. In conclusion, barnidipine + losartan provided a greater improvement of echocardiographic parameters compared to lercanidipine + losartan.

No MeSH data available.


Related in: MedlinePlus