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Neuron hemilineages provide the functional ground plan for the Drosophila ventral nervous system.

Harris RM, Pfeiffer BD, Rubin GM, Truman JW - Elife (2015)

Bottom Line: The next level was hemilineages of similar projection cells that drove intersegmentally coordinated behaviors such as walking.The highest level involved hemilineages whose activation elicited complex behaviors such as takeoff.These activation phenotypes indicate that the hemilineages vary in their behavioral roles with some contributing to local networks for sensorimotor processing and others having higher order functions of coordinating these local networks into complex behavior.

View Article: PubMed Central - PubMed

Affiliation: Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

ABSTRACT
Drosophila central neurons arise from neuroblasts that generate neurons in a pair-wise fashion, with the two daughters providing the basis for distinct A and B hemilineage groups. 33 postembryonically-born hemilineages contribute over 90% of the neurons in each thoracic hemisegment. We devised genetic approaches to define the anatomy of most of these hemilineages and to assessed their functional roles using the heat-sensitive channel dTRPA1. The simplest hemilineages contained local interneurons and their activation caused tonic or phasic leg movements lacking interlimb coordination. The next level was hemilineages of similar projection cells that drove intersegmentally coordinated behaviors such as walking. The highest level involved hemilineages whose activation elicited complex behaviors such as takeoff. These activation phenotypes indicate that the hemilineages vary in their behavioral roles with some contributing to local networks for sensorimotor processing and others having higher order functions of coordinating these local networks into complex behavior.

No MeSH data available.


Related in: MedlinePlus

Dorsal (A) and transverse (B) view of the adult VNS showing a MARCM clone for the T3 lineage 7.From the cell cluster (arrowhead) the cells project dorsally to elaborate a dense arbor (i) in the ipsilateral tectulum neuropil and then cross via an anterior commissure and extend an anterior output arbor (c). They also send a send a second projection that crosses the midline and extends ventrally into leg neuropil (cv). Bracket shows level of transverse projection.DOI:http://dx.doi.org/10.7554/eLife.04493.015
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fig5s1: Dorsal (A) and transverse (B) view of the adult VNS showing a MARCM clone for the T3 lineage 7.From the cell cluster (arrowhead) the cells project dorsally to elaborate a dense arbor (i) in the ipsilateral tectulum neuropil and then cross via an anterior commissure and extend an anterior output arbor (c). They also send a send a second projection that crosses the midline and extends ventrally into leg neuropil (cv). Bracket shows level of transverse projection.DOI:http://dx.doi.org/10.7554/eLife.04493.015

Mentions: Lineage 7 has an anterior cell cluster located in ventrolateral region of neuromeres T1 through A1 and consists of the surviving 7B hemilineage (Truman et al., 2010). The 7B neurite bundle crosses the midline in the iA commissure and then turns anteriorly. The basic morphology is much the same in the adult (Figure 5H), as described in Brown and Truman (2009). The neurite projects dorsally, forming a bushy ipsilateral (proximal) arbor in the tectulum, then crosses the midline to form an ascending tract that extends through the neck connective (Figure 5H). The arbor in the T2 hemineuromere includes prominent projections into the dorsolateral region of the T2 leg neuropil (Figure 5I). The T1 and T3 versions also send a branch into their respective leg neuropils (Figure 5, Figure 5—figure supplement 1), but these branches are not as robust as the T2 version.


Neuron hemilineages provide the functional ground plan for the Drosophila ventral nervous system.

Harris RM, Pfeiffer BD, Rubin GM, Truman JW - Elife (2015)

Dorsal (A) and transverse (B) view of the adult VNS showing a MARCM clone for the T3 lineage 7.From the cell cluster (arrowhead) the cells project dorsally to elaborate a dense arbor (i) in the ipsilateral tectulum neuropil and then cross via an anterior commissure and extend an anterior output arbor (c). They also send a send a second projection that crosses the midline and extends ventrally into leg neuropil (cv). Bracket shows level of transverse projection.DOI:http://dx.doi.org/10.7554/eLife.04493.015
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4525104&req=5

fig5s1: Dorsal (A) and transverse (B) view of the adult VNS showing a MARCM clone for the T3 lineage 7.From the cell cluster (arrowhead) the cells project dorsally to elaborate a dense arbor (i) in the ipsilateral tectulum neuropil and then cross via an anterior commissure and extend an anterior output arbor (c). They also send a send a second projection that crosses the midline and extends ventrally into leg neuropil (cv). Bracket shows level of transverse projection.DOI:http://dx.doi.org/10.7554/eLife.04493.015
Mentions: Lineage 7 has an anterior cell cluster located in ventrolateral region of neuromeres T1 through A1 and consists of the surviving 7B hemilineage (Truman et al., 2010). The 7B neurite bundle crosses the midline in the iA commissure and then turns anteriorly. The basic morphology is much the same in the adult (Figure 5H), as described in Brown and Truman (2009). The neurite projects dorsally, forming a bushy ipsilateral (proximal) arbor in the tectulum, then crosses the midline to form an ascending tract that extends through the neck connective (Figure 5H). The arbor in the T2 hemineuromere includes prominent projections into the dorsolateral region of the T2 leg neuropil (Figure 5I). The T1 and T3 versions also send a branch into their respective leg neuropils (Figure 5, Figure 5—figure supplement 1), but these branches are not as robust as the T2 version.

Bottom Line: The next level was hemilineages of similar projection cells that drove intersegmentally coordinated behaviors such as walking.The highest level involved hemilineages whose activation elicited complex behaviors such as takeoff.These activation phenotypes indicate that the hemilineages vary in their behavioral roles with some contributing to local networks for sensorimotor processing and others having higher order functions of coordinating these local networks into complex behavior.

View Article: PubMed Central - PubMed

Affiliation: Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

ABSTRACT
Drosophila central neurons arise from neuroblasts that generate neurons in a pair-wise fashion, with the two daughters providing the basis for distinct A and B hemilineage groups. 33 postembryonically-born hemilineages contribute over 90% of the neurons in each thoracic hemisegment. We devised genetic approaches to define the anatomy of most of these hemilineages and to assessed their functional roles using the heat-sensitive channel dTRPA1. The simplest hemilineages contained local interneurons and their activation caused tonic or phasic leg movements lacking interlimb coordination. The next level was hemilineages of similar projection cells that drove intersegmentally coordinated behaviors such as walking. The highest level involved hemilineages whose activation elicited complex behaviors such as takeoff. These activation phenotypes indicate that the hemilineages vary in their behavioral roles with some contributing to local networks for sensorimotor processing and others having higher order functions of coordinating these local networks into complex behavior.

No MeSH data available.


Related in: MedlinePlus