Defining the roles of arrestin2 and arrestin3 in vasoconstrictor receptor desensitization in hypertension.
Bottom Line: Desensitization of UTP-stimulated vessel contractions was increased in 12-wk-old (but not 6-wk-old) SHR animals.In conclusion, arrestin2 and 3 expression is elevated in resistance arteries during the emergence of the early hypertensive phenotype, which underlies an enhanced ability to desensitize vasoconstrictor signaling and vessel contraction.Such regulatory changes may act to compensate for increased vasoconstrictor-induced vessel contraction.
Affiliation: Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, United Kingdom; and firstname.lastname@example.org.Show MeSH
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Mentions: The R2/R1 ratios obtained for ET1- and UTP-mediated desensitization in WKY MSMC (both at 6 and 12 wk; Figs. 5 and 6) were similar and were also comparable to those previously observed in adult Wistar MSMC (21, 22). Comparison of experiments undertaken in MSMC isolated from 6-wk-old animals showed that the extent of ET1- and UTP-induced receptor desensitization was comparable in SHR- and WKY-derived cells (Fig. 5E). When similar experiments were conducted in MSMC preparations from 12-wk-old animals, R2/R1 ratios were markedly decreased in SHR- compared with WKY-derived cells, indicating that a greater desensitization of ET1- and UTP-PLC signaling was observed in cells derived from 12-wk, but not 6-wk-old SHR (Fig. 6E).
Affiliation: Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, United Kingdom; and email@example.com.