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Time course of end-tidal desflurane concentration during delivery and elimination according to the type and location of filters in a semi-closed circuit system.

Park SW, Chung JY, Moon EJ, Kang YJ, Kang JM - Korean J Anesthesiol (2015)

Bottom Line: In all groups except the sham, administration of 10% desflurane was performed for 5 minutes and then stopped for 5 minutes.The mean (SD) end-tidal concentration of desflurane for the groups described above peaked at 0 (0), 9.8 (0.1), 9.8 (0.1), 8.5 (0.1), and 6.7% (0.1) (P < 0.001), respectively.Filters can affect the expiratory desflurane concentration during anesthesia.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Pain Medicine, Kyung Hee University Hospital, Seoul, Korea.

ABSTRACT

Background: The aim of this study was to determine whether the end-tidal concentration of desflurane would be affected by a breathing circuit system filter attached at two different positions in anesthetic breathing circuit systems.

Methods: An artificial lung was ventilated under five different conditions. The first group was without any filter or desflurane (n = 5, sham), the second was with desflurane but without any filter (n = 10, control), the third group had a bacterial filter on the expiratory limb (n = 10), and the fourth and fifth groups had a viral/bacterial filter added on the expiratory limb (n = 10) or at the Y-piece of the breathing circuit (n = 10), respectively. In all groups except the sham, administration of 10% desflurane was performed for 5 minutes and then stopped for 5 minutes.

Results: The mean (SD) end-tidal concentration of desflurane for the groups described above peaked at 0 (0), 9.8 (0.1), 9.8 (0.1), 8.5 (0.1), and 6.7% (0.1) (P < 0.001), respectively. There was no difference in the desflurane concentrations and the expired tidal volume over time between the control and bacterial group, but there was a significant difference between the control and the fourth and fifth groups (P < 0.001).

Conclusions: Filters can affect the expiratory desflurane concentration during anesthesia.

No MeSH data available.


Related in: MedlinePlus

Time course of the mean end-tidal desflurane concentration for sham group (n = 5, ◇, solid line), control group (n = 10; ●, solid line), bacterial filter group (SF 10C, Ace Medical, Seoul, Korea; n = 10; △, dotted line), and viral/bacterial filter (MF 10C, Ace Medical) on the expiratory limb (n = 10; ■, dashed line) or at the Y-piece (n = 10; □, dot-dashed line). Error bars are SD. There was no difference in the mean expiratory desflurane concentrations over time between the control group and the bacterial filter group, but significant differences were observed for the groups with the viral/bacterial filter (P < 0.001).
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Figure 3: Time course of the mean end-tidal desflurane concentration for sham group (n = 5, ◇, solid line), control group (n = 10; ●, solid line), bacterial filter group (SF 10C, Ace Medical, Seoul, Korea; n = 10; △, dotted line), and viral/bacterial filter (MF 10C, Ace Medical) on the expiratory limb (n = 10; ■, dashed line) or at the Y-piece (n = 10; □, dot-dashed line). Error bars are SD. There was no difference in the mean expiratory desflurane concentrations over time between the control group and the bacterial filter group, but significant differences were observed for the groups with the viral/bacterial filter (P < 0.001).

Mentions: The recorded desflurane concentration after the first ventilation showed that the inspiratory and expiratory concentrations were the same at every measurement point. However, at 5 minutes after administering desflurane the mean (SD) end-tidal desflurane concentrations peaked at 0% (0) in the sham group, 9.8% (0.1) in the control group, 9.8% (0.1) with the bacterial filter at the expiratory limb, 8.5% (0.1) with the viral/bacterial filter at the expiratory limb, and 6.7% (0.1) with the viral/bacterial filter at the Y-piece (P < 0.001). The time course of the mean end-tidal concentration of desflurane and the mean exhaled tidal volume for each group are plotted in Figs. 3 and 4 respectively. There was no difference in the mean end-tidal concentration of desflurane and the mean exhaled tidal volume over time between the control group and the bacterial filter group, but both showed statistically significant differences between the control and the two groups with viral/bacterial filters (P < 0.001; Figs. 3 and 4). Peak inspiratory airway pressures were similar and maintained at 21-23 cmH2O during the study period irrespective of group except in the group with the viral/bacterial filter group at the Ypiece, which generated pressures between 23 and 25 cmH2O.


Time course of end-tidal desflurane concentration during delivery and elimination according to the type and location of filters in a semi-closed circuit system.

Park SW, Chung JY, Moon EJ, Kang YJ, Kang JM - Korean J Anesthesiol (2015)

Time course of the mean end-tidal desflurane concentration for sham group (n = 5, ◇, solid line), control group (n = 10; ●, solid line), bacterial filter group (SF 10C, Ace Medical, Seoul, Korea; n = 10; △, dotted line), and viral/bacterial filter (MF 10C, Ace Medical) on the expiratory limb (n = 10; ■, dashed line) or at the Y-piece (n = 10; □, dot-dashed line). Error bars are SD. There was no difference in the mean expiratory desflurane concentrations over time between the control group and the bacterial filter group, but significant differences were observed for the groups with the viral/bacterial filter (P < 0.001).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4524939&req=5

Figure 3: Time course of the mean end-tidal desflurane concentration for sham group (n = 5, ◇, solid line), control group (n = 10; ●, solid line), bacterial filter group (SF 10C, Ace Medical, Seoul, Korea; n = 10; △, dotted line), and viral/bacterial filter (MF 10C, Ace Medical) on the expiratory limb (n = 10; ■, dashed line) or at the Y-piece (n = 10; □, dot-dashed line). Error bars are SD. There was no difference in the mean expiratory desflurane concentrations over time between the control group and the bacterial filter group, but significant differences were observed for the groups with the viral/bacterial filter (P < 0.001).
Mentions: The recorded desflurane concentration after the first ventilation showed that the inspiratory and expiratory concentrations were the same at every measurement point. However, at 5 minutes after administering desflurane the mean (SD) end-tidal desflurane concentrations peaked at 0% (0) in the sham group, 9.8% (0.1) in the control group, 9.8% (0.1) with the bacterial filter at the expiratory limb, 8.5% (0.1) with the viral/bacterial filter at the expiratory limb, and 6.7% (0.1) with the viral/bacterial filter at the Y-piece (P < 0.001). The time course of the mean end-tidal concentration of desflurane and the mean exhaled tidal volume for each group are plotted in Figs. 3 and 4 respectively. There was no difference in the mean end-tidal concentration of desflurane and the mean exhaled tidal volume over time between the control group and the bacterial filter group, but both showed statistically significant differences between the control and the two groups with viral/bacterial filters (P < 0.001; Figs. 3 and 4). Peak inspiratory airway pressures were similar and maintained at 21-23 cmH2O during the study period irrespective of group except in the group with the viral/bacterial filter group at the Ypiece, which generated pressures between 23 and 25 cmH2O.

Bottom Line: In all groups except the sham, administration of 10% desflurane was performed for 5 minutes and then stopped for 5 minutes.The mean (SD) end-tidal concentration of desflurane for the groups described above peaked at 0 (0), 9.8 (0.1), 9.8 (0.1), 8.5 (0.1), and 6.7% (0.1) (P < 0.001), respectively.Filters can affect the expiratory desflurane concentration during anesthesia.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Pain Medicine, Kyung Hee University Hospital, Seoul, Korea.

ABSTRACT

Background: The aim of this study was to determine whether the end-tidal concentration of desflurane would be affected by a breathing circuit system filter attached at two different positions in anesthetic breathing circuit systems.

Methods: An artificial lung was ventilated under five different conditions. The first group was without any filter or desflurane (n = 5, sham), the second was with desflurane but without any filter (n = 10, control), the third group had a bacterial filter on the expiratory limb (n = 10), and the fourth and fifth groups had a viral/bacterial filter added on the expiratory limb (n = 10) or at the Y-piece of the breathing circuit (n = 10), respectively. In all groups except the sham, administration of 10% desflurane was performed for 5 minutes and then stopped for 5 minutes.

Results: The mean (SD) end-tidal concentration of desflurane for the groups described above peaked at 0 (0), 9.8 (0.1), 9.8 (0.1), 8.5 (0.1), and 6.7% (0.1) (P < 0.001), respectively. There was no difference in the desflurane concentrations and the expired tidal volume over time between the control and bacterial group, but there was a significant difference between the control and the fourth and fifth groups (P < 0.001).

Conclusions: Filters can affect the expiratory desflurane concentration during anesthesia.

No MeSH data available.


Related in: MedlinePlus