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Time course of end-tidal desflurane concentration during delivery and elimination according to the type and location of filters in a semi-closed circuit system.

Park SW, Chung JY, Moon EJ, Kang YJ, Kang JM - Korean J Anesthesiol (2015)

Bottom Line: In all groups except the sham, administration of 10% desflurane was performed for 5 minutes and then stopped for 5 minutes.The mean (SD) end-tidal concentration of desflurane for the groups described above peaked at 0 (0), 9.8 (0.1), 9.8 (0.1), 8.5 (0.1), and 6.7% (0.1) (P < 0.001), respectively.Filters can affect the expiratory desflurane concentration during anesthesia.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Pain Medicine, Kyung Hee University Hospital, Seoul, Korea.

ABSTRACT

Background: The aim of this study was to determine whether the end-tidal concentration of desflurane would be affected by a breathing circuit system filter attached at two different positions in anesthetic breathing circuit systems.

Methods: An artificial lung was ventilated under five different conditions. The first group was without any filter or desflurane (n = 5, sham), the second was with desflurane but without any filter (n = 10, control), the third group had a bacterial filter on the expiratory limb (n = 10), and the fourth and fifth groups had a viral/bacterial filter added on the expiratory limb (n = 10) or at the Y-piece of the breathing circuit (n = 10), respectively. In all groups except the sham, administration of 10% desflurane was performed for 5 minutes and then stopped for 5 minutes.

Results: The mean (SD) end-tidal concentration of desflurane for the groups described above peaked at 0 (0), 9.8 (0.1), 9.8 (0.1), 8.5 (0.1), and 6.7% (0.1) (P < 0.001), respectively. There was no difference in the desflurane concentrations and the expired tidal volume over time between the control and bacterial group, but there was a significant difference between the control and the fourth and fifth groups (P < 0.001).

Conclusions: Filters can affect the expiratory desflurane concentration during anesthesia.

No MeSH data available.


Related in: MedlinePlus

External and internal (cut) appearance. (A) Bacterial filter (SF 10C, Ace Medical, Seoul, Korea). (B) Viral/bacterial filter (MF 10C, Ace Medical, Seoul, Korea).
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Figure 2: External and internal (cut) appearance. (A) Bacterial filter (SF 10C, Ace Medical, Seoul, Korea). (B) Viral/bacterial filter (MF 10C, Ace Medical, Seoul, Korea).

Mentions: An artificial lung (5 L reservoir bag) was connected to a breathing circuit system (Fig. 1) of an anesthetic machine (Primus, Dräger Medizintechnik GmbH, Lübeck, Germany) [6]. The study groups had no filter (a sham group with no anesthetic gas [n = 5] and a control group with anesthetic gas [n = 10]), a bacterial filter (SF 10C, Ace Medical, Seoul, Korea; n = 10) or a viral/bacterial filter (MF 10C, Ace Medical; n = 10) (Fig. 2) added to the expiratory limb of the circuit where the expiratory limb connects with the anesthesia machine, or a viral/bacterial filter added at the Y-piece of the breathing circuit system (n = 10). The artificial lung was ventilated with 100% O2 at a fresh gas flow of 4 L/min (tidal volume of 600 ml and respiratory rate of 12 /min). Desflurane was administered at a vaporizer dial setting of 10% for 5 minutes and then the dial setting was turned to zero for the next 5 minutes. Desflurane was not administered in the sham group. The inspiratory and expiratory desflurane concentrations were measured at the Y-piece via a side-stream sampling tube and recorded every 30 seconds using the Dräger Infinity Delta Monitor (Dräger Medical AG & CO, Lübeck, Germany). The exhaled tidal volume and the peak inspiratory airway pressure were also measured.


Time course of end-tidal desflurane concentration during delivery and elimination according to the type and location of filters in a semi-closed circuit system.

Park SW, Chung JY, Moon EJ, Kang YJ, Kang JM - Korean J Anesthesiol (2015)

External and internal (cut) appearance. (A) Bacterial filter (SF 10C, Ace Medical, Seoul, Korea). (B) Viral/bacterial filter (MF 10C, Ace Medical, Seoul, Korea).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4524939&req=5

Figure 2: External and internal (cut) appearance. (A) Bacterial filter (SF 10C, Ace Medical, Seoul, Korea). (B) Viral/bacterial filter (MF 10C, Ace Medical, Seoul, Korea).
Mentions: An artificial lung (5 L reservoir bag) was connected to a breathing circuit system (Fig. 1) of an anesthetic machine (Primus, Dräger Medizintechnik GmbH, Lübeck, Germany) [6]. The study groups had no filter (a sham group with no anesthetic gas [n = 5] and a control group with anesthetic gas [n = 10]), a bacterial filter (SF 10C, Ace Medical, Seoul, Korea; n = 10) or a viral/bacterial filter (MF 10C, Ace Medical; n = 10) (Fig. 2) added to the expiratory limb of the circuit where the expiratory limb connects with the anesthesia machine, or a viral/bacterial filter added at the Y-piece of the breathing circuit system (n = 10). The artificial lung was ventilated with 100% O2 at a fresh gas flow of 4 L/min (tidal volume of 600 ml and respiratory rate of 12 /min). Desflurane was administered at a vaporizer dial setting of 10% for 5 minutes and then the dial setting was turned to zero for the next 5 minutes. Desflurane was not administered in the sham group. The inspiratory and expiratory desflurane concentrations were measured at the Y-piece via a side-stream sampling tube and recorded every 30 seconds using the Dräger Infinity Delta Monitor (Dräger Medical AG & CO, Lübeck, Germany). The exhaled tidal volume and the peak inspiratory airway pressure were also measured.

Bottom Line: In all groups except the sham, administration of 10% desflurane was performed for 5 minutes and then stopped for 5 minutes.The mean (SD) end-tidal concentration of desflurane for the groups described above peaked at 0 (0), 9.8 (0.1), 9.8 (0.1), 8.5 (0.1), and 6.7% (0.1) (P < 0.001), respectively.Filters can affect the expiratory desflurane concentration during anesthesia.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Pain Medicine, Kyung Hee University Hospital, Seoul, Korea.

ABSTRACT

Background: The aim of this study was to determine whether the end-tidal concentration of desflurane would be affected by a breathing circuit system filter attached at two different positions in anesthetic breathing circuit systems.

Methods: An artificial lung was ventilated under five different conditions. The first group was without any filter or desflurane (n = 5, sham), the second was with desflurane but without any filter (n = 10, control), the third group had a bacterial filter on the expiratory limb (n = 10), and the fourth and fifth groups had a viral/bacterial filter added on the expiratory limb (n = 10) or at the Y-piece of the breathing circuit (n = 10), respectively. In all groups except the sham, administration of 10% desflurane was performed for 5 minutes and then stopped for 5 minutes.

Results: The mean (SD) end-tidal concentration of desflurane for the groups described above peaked at 0 (0), 9.8 (0.1), 9.8 (0.1), 8.5 (0.1), and 6.7% (0.1) (P < 0.001), respectively. There was no difference in the desflurane concentrations and the expired tidal volume over time between the control and bacterial group, but there was a significant difference between the control and the fourth and fifth groups (P < 0.001).

Conclusions: Filters can affect the expiratory desflurane concentration during anesthesia.

No MeSH data available.


Related in: MedlinePlus