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A comparison of postoperative emergence agitation between sevoflurane and thiopental anesthesia induction in pediatric patients.

Son JS, Jang E, Oh MW, Lee JH, Han YJ, Ko S - Korean J Anesthesiol (2015)

Bottom Line: The incidence of EA was significantly lower in Group T compared to Group S at 5 min after PACU arrival (3/49 patients, 6% vs. 12/47 patients, 26%, P = 0.019).The number of children who received propofol as a rescue agent was significantly lower in Group T (Group S: 14/47 vs.Intravenous anesthesia induction with thiopental reduced the incidence of EA in the early PACU period compared to inhalation induction with sevoflurane in 3- to 7-year-old children undergoing sevoflurane anesthesia.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Pain Medicine, Chonbuk National University Medical School and Hospital, Jeonju, Korea.

ABSTRACT

Background: This study was performed to compare the incidence of emergence agitation (EA) between inhalation and intravenous anesthesia induction in children after sevoflurane anesthesia.

Methods: In this prospective and double-blind study, 100 children aged 3 to 7 years were enrolled. Subjects were randomly assigned to the sevoflurane (Group S) or thiopental (Group T) anesthesia induction groups. Anesthesia was induced using 8% sevoflurane and 4-6 mg/kg thiopental in Groups S and T, respectively. Anesthesia was maintained with nitrous oxide and sevoflurane. The children were evaluated at 5 and 20 min after arrival in the postanesthesia care unit (PACU) with a four-point agitation scale and the Pediatric Anesthesia Emergence Delirium scale. The incidence of EA and administration of the rescue agent were recorded.

Results: The incidence of EA was significantly lower in Group T compared to Group S at 5 min after PACU arrival (3/49 patients, 6% vs. 12/47 patients, 26%, P = 0.019). However, there was no difference between the two groups at 20 min after PACU arrival (23/49 vs. 19/47 patients in Group T vs. Group S, P = 0.425). The overall incidence of EA was 60% (28/47 patients) in Group S and 41% (20/49 patients) in Group T (P = 0.102). The number of children who received propofol as a rescue agent was significantly lower in Group T (Group S: 14/47 vs. Group T: 5/49, P = 0.031).

Conclusions: Intravenous anesthesia induction with thiopental reduced the incidence of EA in the early PACU period compared to inhalation induction with sevoflurane in 3- to 7-year-old children undergoing sevoflurane anesthesia.

No MeSH data available.


Related in: MedlinePlus

Subject flow diagram. Group S: sevoflurane inhalation anesthesia induction group, Group T: intravenous thiopental anesthesia induction group.
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Figure 1: Subject flow diagram. Group S: sevoflurane inhalation anesthesia induction group, Group T: intravenous thiopental anesthesia induction group.

Mentions: Ninty-six children completed the study and the subject flow diagram is show in Fig. 1. The characteristics of the patients are comparable in both groups (Table 1). The median preoperative anxiety scores using the mYPAS in the operating room were not different between the two groups (Group S: 31.7 [23.3-40.0] vs. Group T: 31.7 [25.0-46.7], P = 0.211). The time from the end of sevoflurane administration to extubation was also similar in the two groups (Group S: 6.8 ± 2.8 min vs. Group T: 7.5 ± 3.2 min, P = 0.258).


A comparison of postoperative emergence agitation between sevoflurane and thiopental anesthesia induction in pediatric patients.

Son JS, Jang E, Oh MW, Lee JH, Han YJ, Ko S - Korean J Anesthesiol (2015)

Subject flow diagram. Group S: sevoflurane inhalation anesthesia induction group, Group T: intravenous thiopental anesthesia induction group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4524936&req=5

Figure 1: Subject flow diagram. Group S: sevoflurane inhalation anesthesia induction group, Group T: intravenous thiopental anesthesia induction group.
Mentions: Ninty-six children completed the study and the subject flow diagram is show in Fig. 1. The characteristics of the patients are comparable in both groups (Table 1). The median preoperative anxiety scores using the mYPAS in the operating room were not different between the two groups (Group S: 31.7 [23.3-40.0] vs. Group T: 31.7 [25.0-46.7], P = 0.211). The time from the end of sevoflurane administration to extubation was also similar in the two groups (Group S: 6.8 ± 2.8 min vs. Group T: 7.5 ± 3.2 min, P = 0.258).

Bottom Line: The incidence of EA was significantly lower in Group T compared to Group S at 5 min after PACU arrival (3/49 patients, 6% vs. 12/47 patients, 26%, P = 0.019).The number of children who received propofol as a rescue agent was significantly lower in Group T (Group S: 14/47 vs.Intravenous anesthesia induction with thiopental reduced the incidence of EA in the early PACU period compared to inhalation induction with sevoflurane in 3- to 7-year-old children undergoing sevoflurane anesthesia.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Pain Medicine, Chonbuk National University Medical School and Hospital, Jeonju, Korea.

ABSTRACT

Background: This study was performed to compare the incidence of emergence agitation (EA) between inhalation and intravenous anesthesia induction in children after sevoflurane anesthesia.

Methods: In this prospective and double-blind study, 100 children aged 3 to 7 years were enrolled. Subjects were randomly assigned to the sevoflurane (Group S) or thiopental (Group T) anesthesia induction groups. Anesthesia was induced using 8% sevoflurane and 4-6 mg/kg thiopental in Groups S and T, respectively. Anesthesia was maintained with nitrous oxide and sevoflurane. The children were evaluated at 5 and 20 min after arrival in the postanesthesia care unit (PACU) with a four-point agitation scale and the Pediatric Anesthesia Emergence Delirium scale. The incidence of EA and administration of the rescue agent were recorded.

Results: The incidence of EA was significantly lower in Group T compared to Group S at 5 min after PACU arrival (3/49 patients, 6% vs. 12/47 patients, 26%, P = 0.019). However, there was no difference between the two groups at 20 min after PACU arrival (23/49 vs. 19/47 patients in Group T vs. Group S, P = 0.425). The overall incidence of EA was 60% (28/47 patients) in Group S and 41% (20/49 patients) in Group T (P = 0.102). The number of children who received propofol as a rescue agent was significantly lower in Group T (Group S: 14/47 vs. Group T: 5/49, P = 0.031).

Conclusions: Intravenous anesthesia induction with thiopental reduced the incidence of EA in the early PACU period compared to inhalation induction with sevoflurane in 3- to 7-year-old children undergoing sevoflurane anesthesia.

No MeSH data available.


Related in: MedlinePlus