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Porcine epidemic diarrhea: a review of current epidemiology and available vaccines.

Song D, Moon H, Kang B - Clin Exp Vaccine Res (2015)

Bottom Line: Although PEDV was first identified in Europe, it has resulted in significant economic losses in many Asian swine-raising countries, including Korea, China, Japan, Vietnam, and the Philippines.Moreover, intercontinental transmission of PEDV has increased mortality rates in seronegative neonatal piglets, resulting in 10% loss of the US pig population.We also discuss PEDV vaccines and related issues.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, College of Pharmacy, Korea University, Sejong, Korea.

ABSTRACT
Porcine epidemic diarrhea virus (PEDV), an Alphacoronavirus in the family Coronaviridae, causes acute diarrhea, vomiting, dehydration, and high mortality rates in neonatal piglets. PEDV can also cause diarrhea, agalactia, and abnormal reproductive cycles in pregnant sows. Although PEDV was first identified in Europe, it has resulted in significant economic losses in many Asian swine-raising countries, including Korea, China, Japan, Vietnam, and the Philippines. However, from April 2013 to the present, major outbreaks of PEDV have been reported in the United States, Canada, and Mexico. Moreover, intercontinental transmission of PEDV has increased mortality rates in seronegative neonatal piglets, resulting in 10% loss of the US pig population. The emergence and re-emergence of PEDV indicates that the virus is able to evade current vaccine strategies. Continuous emergence of multiple mutant strains from several regions has aggravated porcine epidemic diarrhea endemic conditions and highlighted the need for new vaccines based on the current circulating PEDV. Epidemic PEDV strains tend to be more pathogenic and cause increased death in pigs, thereby causing substantial financial losses for swine producers. In this review, we described the epidemiology of PEDV in several countries and present molecular characterization of current strains. We also discuss PEDV vaccines and related issues.

No MeSH data available.


Related in: MedlinePlus

Results of an immunochromatographic assay kit that can be used for porcine epidemic diarrhea virus (PEDV) detection. (A) The upper and lower panels show positive and negative results, respectively. (B) Dual-detecting immunochromatographic kit for the detection of PEDV and porcine rotavirus.
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Figure 3: Results of an immunochromatographic assay kit that can be used for porcine epidemic diarrhea virus (PEDV) detection. (A) The upper and lower panels show positive and negative results, respectively. (B) Dual-detecting immunochromatographic kit for the detection of PEDV and porcine rotavirus.

Mentions: Another useful reverse transcription-based diagnostic tool is RT loop-mediated isothermal amplification. This assay, which uses 4-6 primers that recognize 6-8 regions of the target DNA, is more sensitive than gel-based RT-PCR and ELISA, largely because this method produces a greater quantity of DNA [65]. Immunochromatographic assay kits can be used at farms in order to detect the N (nucleocapsid) protein of PEDV with 92% sensitivity and 98% specificity. Moreover, a rapid technique for differential detection of PEDV and porcine rotavirus (RV) has recently been commercialized and is now widely used in the field (Fig. 3). This technique is less sensitive than RT-PCR, but allows for diagnosis within 10 minutes. Thus, it is particularly effective for quickly determining quarantine or slaughter policies in the field.


Porcine epidemic diarrhea: a review of current epidemiology and available vaccines.

Song D, Moon H, Kang B - Clin Exp Vaccine Res (2015)

Results of an immunochromatographic assay kit that can be used for porcine epidemic diarrhea virus (PEDV) detection. (A) The upper and lower panels show positive and negative results, respectively. (B) Dual-detecting immunochromatographic kit for the detection of PEDV and porcine rotavirus.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4524901&req=5

Figure 3: Results of an immunochromatographic assay kit that can be used for porcine epidemic diarrhea virus (PEDV) detection. (A) The upper and lower panels show positive and negative results, respectively. (B) Dual-detecting immunochromatographic kit for the detection of PEDV and porcine rotavirus.
Mentions: Another useful reverse transcription-based diagnostic tool is RT loop-mediated isothermal amplification. This assay, which uses 4-6 primers that recognize 6-8 regions of the target DNA, is more sensitive than gel-based RT-PCR and ELISA, largely because this method produces a greater quantity of DNA [65]. Immunochromatographic assay kits can be used at farms in order to detect the N (nucleocapsid) protein of PEDV with 92% sensitivity and 98% specificity. Moreover, a rapid technique for differential detection of PEDV and porcine rotavirus (RV) has recently been commercialized and is now widely used in the field (Fig. 3). This technique is less sensitive than RT-PCR, but allows for diagnosis within 10 minutes. Thus, it is particularly effective for quickly determining quarantine or slaughter policies in the field.

Bottom Line: Although PEDV was first identified in Europe, it has resulted in significant economic losses in many Asian swine-raising countries, including Korea, China, Japan, Vietnam, and the Philippines.Moreover, intercontinental transmission of PEDV has increased mortality rates in seronegative neonatal piglets, resulting in 10% loss of the US pig population.We also discuss PEDV vaccines and related issues.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, College of Pharmacy, Korea University, Sejong, Korea.

ABSTRACT
Porcine epidemic diarrhea virus (PEDV), an Alphacoronavirus in the family Coronaviridae, causes acute diarrhea, vomiting, dehydration, and high mortality rates in neonatal piglets. PEDV can also cause diarrhea, agalactia, and abnormal reproductive cycles in pregnant sows. Although PEDV was first identified in Europe, it has resulted in significant economic losses in many Asian swine-raising countries, including Korea, China, Japan, Vietnam, and the Philippines. However, from April 2013 to the present, major outbreaks of PEDV have been reported in the United States, Canada, and Mexico. Moreover, intercontinental transmission of PEDV has increased mortality rates in seronegative neonatal piglets, resulting in 10% loss of the US pig population. The emergence and re-emergence of PEDV indicates that the virus is able to evade current vaccine strategies. Continuous emergence of multiple mutant strains from several regions has aggravated porcine epidemic diarrhea endemic conditions and highlighted the need for new vaccines based on the current circulating PEDV. Epidemic PEDV strains tend to be more pathogenic and cause increased death in pigs, thereby causing substantial financial losses for swine producers. In this review, we described the epidemiology of PEDV in several countries and present molecular characterization of current strains. We also discuss PEDV vaccines and related issues.

No MeSH data available.


Related in: MedlinePlus