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Malignant glomus tumor of the lung with multiorgan metastases: case report and literature review.

Dong LL, Chen EG, Sheikh IS, Jiang ZN, Huang AH, Ying KJ - Onco Targets Ther (2015)

Bottom Line: A polypoid mass was found to occlude the left lingular lobar bronchus.Final histopathologic examination showed the presence of malignant glomus tumor, confirmed by immunoreactivity for smooth muscle actin and vimentin.Further evaluation lead to the discovery of widespread metastatic disease to the gastrointestinal tract, spleen, and the left adrenal gland.

View Article: PubMed Central - PubMed

Affiliation: Department of Pulmonary Medicine, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, People's Republic of China.

ABSTRACT
Glomus tumor is an exceedingly rare neoplasm that is derived from cells of the neuromyoarterial glomus or glomus body. It rarely occurs in the visceral organs where glomus body may be sparse or even absent, such as the stomach, intestines, mediastinum, and respiratory tract. It is unusual for a glomus tumor to demonstrate atypical or malignant histopathological characteristics. It is also rare for such a tumor to express clinically aggressive behavior. However, when metastasis does occur, this disease is often fatal. We herein report an interesting case of a middle-age woman admitted due to progressive cough and hemoptysis. A polypoid mass was found to occlude the left lingular lobar bronchus. Final histopathologic examination showed the presence of malignant glomus tumor, confirmed by immunoreactivity for smooth muscle actin and vimentin. Two months later, the patient developed abdominal distension and gastrointestinal bleeding. Further evaluation lead to the discovery of widespread metastatic disease to the gastrointestinal tract, spleen, and the left adrenal gland. We further entail a review of the literature on the clinicopathologic features and diagnosis of this uncommon tumor.

No MeSH data available.


Related in: MedlinePlus

Findings from endoscopy.Notes: (A) Bronchoscopy demonstrated a tumor mass in the left lingual bronchus (arrow). (B) The tumor projected into the left main bronchus on the second admission (arrow). (C) Gastroscopy demonstrated multiple submucosal masses in the fundus of the stomach (arrows). (D) Multiple lesions were also seen in the duodenum (arrows).
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f2-ott-8-1909: Findings from endoscopy.Notes: (A) Bronchoscopy demonstrated a tumor mass in the left lingual bronchus (arrow). (B) The tumor projected into the left main bronchus on the second admission (arrow). (C) Gastroscopy demonstrated multiple submucosal masses in the fundus of the stomach (arrows). (D) Multiple lesions were also seen in the duodenum (arrows).

Mentions: Electronic bronchoscopy was then done revealing a white polypoid tumor, which occupied the left lingular bronchus without any signs of invasion or protrusion into the left main bronchus (Figure 2A). Biopsy of the tumor was taken and sent for pathology, which revealed inflammatory exudates and various degrees of necrosis. The patient once got a similar pathological report at another hospital where she had undergone bronchoscopic biopsy and lung puncture before arrival at our hospital. These inconclusive results were not enough to identify the final diagnosis. The patient was then discharged home but was lost to follow-up in 1 month.


Malignant glomus tumor of the lung with multiorgan metastases: case report and literature review.

Dong LL, Chen EG, Sheikh IS, Jiang ZN, Huang AH, Ying KJ - Onco Targets Ther (2015)

Findings from endoscopy.Notes: (A) Bronchoscopy demonstrated a tumor mass in the left lingual bronchus (arrow). (B) The tumor projected into the left main bronchus on the second admission (arrow). (C) Gastroscopy demonstrated multiple submucosal masses in the fundus of the stomach (arrows). (D) Multiple lesions were also seen in the duodenum (arrows).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4524584&req=5

f2-ott-8-1909: Findings from endoscopy.Notes: (A) Bronchoscopy demonstrated a tumor mass in the left lingual bronchus (arrow). (B) The tumor projected into the left main bronchus on the second admission (arrow). (C) Gastroscopy demonstrated multiple submucosal masses in the fundus of the stomach (arrows). (D) Multiple lesions were also seen in the duodenum (arrows).
Mentions: Electronic bronchoscopy was then done revealing a white polypoid tumor, which occupied the left lingular bronchus without any signs of invasion or protrusion into the left main bronchus (Figure 2A). Biopsy of the tumor was taken and sent for pathology, which revealed inflammatory exudates and various degrees of necrosis. The patient once got a similar pathological report at another hospital where she had undergone bronchoscopic biopsy and lung puncture before arrival at our hospital. These inconclusive results were not enough to identify the final diagnosis. The patient was then discharged home but was lost to follow-up in 1 month.

Bottom Line: A polypoid mass was found to occlude the left lingular lobar bronchus.Final histopathologic examination showed the presence of malignant glomus tumor, confirmed by immunoreactivity for smooth muscle actin and vimentin.Further evaluation lead to the discovery of widespread metastatic disease to the gastrointestinal tract, spleen, and the left adrenal gland.

View Article: PubMed Central - PubMed

Affiliation: Department of Pulmonary Medicine, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, People's Republic of China.

ABSTRACT
Glomus tumor is an exceedingly rare neoplasm that is derived from cells of the neuromyoarterial glomus or glomus body. It rarely occurs in the visceral organs where glomus body may be sparse or even absent, such as the stomach, intestines, mediastinum, and respiratory tract. It is unusual for a glomus tumor to demonstrate atypical or malignant histopathological characteristics. It is also rare for such a tumor to express clinically aggressive behavior. However, when metastasis does occur, this disease is often fatal. We herein report an interesting case of a middle-age woman admitted due to progressive cough and hemoptysis. A polypoid mass was found to occlude the left lingular lobar bronchus. Final histopathologic examination showed the presence of malignant glomus tumor, confirmed by immunoreactivity for smooth muscle actin and vimentin. Two months later, the patient developed abdominal distension and gastrointestinal bleeding. Further evaluation lead to the discovery of widespread metastatic disease to the gastrointestinal tract, spleen, and the left adrenal gland. We further entail a review of the literature on the clinicopathologic features and diagnosis of this uncommon tumor.

No MeSH data available.


Related in: MedlinePlus