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-148 C/T polymorphism of Axin2 contributes to a decreased risk of cancer: evidence from a meta-analysis.

Zhong A, Pan X, Shi M, Xu H - Onco Targets Ther (2015)

Bottom Line: CMA showed an association trend, and the recursive CMA indicated that more evidence is needed to make conclusions about significance.The Axin2 -148 C/T polymorphism was found to be significantly associated with a decreased risk of cancer, particularly lung cancer, in Asians and population-based controls.Thus, Axin2 should be considered as a potential therapeutic target for preventing tumor growth.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Diseases, The Second Affiliated Hospital of Soochow University, Suzhou, People's Republic of China.

ABSTRACT
Several studies have reported an association between -148 C/T polymorphism of Axis inhibition protein 2 (Axin2) and cancer risk; however, the results are inconsistent. In this study, a meta-analysis was performed to assess the association between -148 C/T polymorphism of Axin2 and susceptibility to cancer. Published case-control and cohort-based studies from PubMed, Embase, Wanfang, and CNKI were retrieved, and data were manually extracted. The odds ratios (ORs) and 95% confidence intervals (CIs) of the included studies were pooled. Begg's and Egger's tests were used to evaluate publication bias. Cumulative and recursive cumulative meta-analyses (CMA) were performed as evidence accumulated to investigate the trends and stability of the effect size. Nine articles with 1,664 cases and 1,796 controls were included. The pooled effect size showed an association between -148 C/T polymorphism and the risk of cancer (dominant model, OR: 0.72, 95% CI: 0.63-0.83; allele model, OR: 0.81, 95% CI: 0.73-0.90). CMA showed an association trend, and the recursive CMA indicated that more evidence is needed to make conclusions about significance. In a subgroup analysis, a significant association between -148 C/T polymorphism and low cancer susceptibility was detected for lung cancer (dominant model, 0.69, 95% CI: 0.56-0.85; recessive model, OR: 0.75, 95% CI: 0.56-0.99; allele model, 0.76, 95% CI: 0.66-0.86). The -148 C/T polymorphism was also associated with low cancer susceptibility among Asians (dominant model, OR: 0.68, 95% CI: 0.57-0.81; recessive model, OR: 0.75, 95% CI: 0.56-0.99; allele model, OR: 0.76, 95% CI: 0.66-0.86). The Axin2 -148 C/T polymorphism was found to be significantly associated with a decreased risk of cancer, particularly lung cancer, in Asians and population-based controls. Thus, Axin2 should be considered as a potential therapeutic target for preventing tumor growth.

No MeSH data available.


Related in: MedlinePlus

Forest plot of the association between the Axin2 −148 C/T polymorphism (dominant model) and cancer risk.Abbreviations: Axin2, Axis inhibition protein 2; OR, odds ratio; CI, confidence interval.
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f2-ott-8-1957: Forest plot of the association between the Axin2 −148 C/T polymorphism (dominant model) and cancer risk.Abbreviations: Axin2, Axis inhibition protein 2; OR, odds ratio; CI, confidence interval.

Mentions: In dominant, recessive, and allele models, no significant between-study heterogeneity was found among the included studies (I2=0.0%, P=0.62; I2=9.2%, P=0.356; and I2=5.2%, P=0.394, respectively), so a fixed-effects model was used to analyze the data. The pooled data indicated a significant association between −148 C/T polymorphism of Axin2 and a decreased risk of cancer using a dominant model and an allele model (OR: 0.72, 95% CI: 0.63–0.83; OR: 0.81, 95% CI: 0.73–0.90, respectively) (Figures 2 and 3). The Axin −148 C/T polymorphism was not significantly associated with cancer risk in the recessive model (OR=0.84, 95% CI 0.69–1.02) (Figure 4).


-148 C/T polymorphism of Axin2 contributes to a decreased risk of cancer: evidence from a meta-analysis.

Zhong A, Pan X, Shi M, Xu H - Onco Targets Ther (2015)

Forest plot of the association between the Axin2 −148 C/T polymorphism (dominant model) and cancer risk.Abbreviations: Axin2, Axis inhibition protein 2; OR, odds ratio; CI, confidence interval.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4524579&req=5

f2-ott-8-1957: Forest plot of the association between the Axin2 −148 C/T polymorphism (dominant model) and cancer risk.Abbreviations: Axin2, Axis inhibition protein 2; OR, odds ratio; CI, confidence interval.
Mentions: In dominant, recessive, and allele models, no significant between-study heterogeneity was found among the included studies (I2=0.0%, P=0.62; I2=9.2%, P=0.356; and I2=5.2%, P=0.394, respectively), so a fixed-effects model was used to analyze the data. The pooled data indicated a significant association between −148 C/T polymorphism of Axin2 and a decreased risk of cancer using a dominant model and an allele model (OR: 0.72, 95% CI: 0.63–0.83; OR: 0.81, 95% CI: 0.73–0.90, respectively) (Figures 2 and 3). The Axin −148 C/T polymorphism was not significantly associated with cancer risk in the recessive model (OR=0.84, 95% CI 0.69–1.02) (Figure 4).

Bottom Line: CMA showed an association trend, and the recursive CMA indicated that more evidence is needed to make conclusions about significance.The Axin2 -148 C/T polymorphism was found to be significantly associated with a decreased risk of cancer, particularly lung cancer, in Asians and population-based controls.Thus, Axin2 should be considered as a potential therapeutic target for preventing tumor growth.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Diseases, The Second Affiliated Hospital of Soochow University, Suzhou, People's Republic of China.

ABSTRACT
Several studies have reported an association between -148 C/T polymorphism of Axis inhibition protein 2 (Axin2) and cancer risk; however, the results are inconsistent. In this study, a meta-analysis was performed to assess the association between -148 C/T polymorphism of Axin2 and susceptibility to cancer. Published case-control and cohort-based studies from PubMed, Embase, Wanfang, and CNKI were retrieved, and data were manually extracted. The odds ratios (ORs) and 95% confidence intervals (CIs) of the included studies were pooled. Begg's and Egger's tests were used to evaluate publication bias. Cumulative and recursive cumulative meta-analyses (CMA) were performed as evidence accumulated to investigate the trends and stability of the effect size. Nine articles with 1,664 cases and 1,796 controls were included. The pooled effect size showed an association between -148 C/T polymorphism and the risk of cancer (dominant model, OR: 0.72, 95% CI: 0.63-0.83; allele model, OR: 0.81, 95% CI: 0.73-0.90). CMA showed an association trend, and the recursive CMA indicated that more evidence is needed to make conclusions about significance. In a subgroup analysis, a significant association between -148 C/T polymorphism and low cancer susceptibility was detected for lung cancer (dominant model, 0.69, 95% CI: 0.56-0.85; recessive model, OR: 0.75, 95% CI: 0.56-0.99; allele model, 0.76, 95% CI: 0.66-0.86). The -148 C/T polymorphism was also associated with low cancer susceptibility among Asians (dominant model, OR: 0.68, 95% CI: 0.57-0.81; recessive model, OR: 0.75, 95% CI: 0.56-0.99; allele model, OR: 0.76, 95% CI: 0.66-0.86). The Axin2 -148 C/T polymorphism was found to be significantly associated with a decreased risk of cancer, particularly lung cancer, in Asians and population-based controls. Thus, Axin2 should be considered as a potential therapeutic target for preventing tumor growth.

No MeSH data available.


Related in: MedlinePlus