Phylogeographic Refinement and Large Scale Genotyping of Human Y Chromosome Haplogroup E Provide New Insights into the Dispersal of Early Pastoralists in the African Continent.
Bottom Line: To increase the level of resolution of haplogroup E, we disclosed the phylogenetic relationships among 729 mutations found in 33 haplogroup DE Y-chromosomes sequenced at high coverage in previous studies.The phylogeny of haplogroup E showed novel features compared with the previous topology, including a new basal dichotomy.In addition, our results increase the discriminative power of the E-M35 haplogroup for use in forensic genetics through the identification of new ancestry-informative markers.
Affiliation: Dipartimento di Biologia e Biotecnologie "C. Darwin," Sapienza Università di Roma, Italy.Show MeSH
Mentions: We used the 729 haplogroup E DNA variants to reconstruct an MP patrilineal tree using two independent methods that produced trees with identical topology, and indicated no recurrent or double-hit mutations within the phylogeny. The MP tree is shown in figure 1.Fig. 1.
Affiliation: Dipartimento di Biologia e Biotecnologie "C. Darwin," Sapienza Università di Roma, Italy.