Variation in the X:Autosome Distribution of Male-Biased Genes among Drosophila melanogaster Tissues and Its Relationship with Dosage Compensation.
Bottom Line: Previous studies of Drosophila melanogaster found a general paucity of male-biased genes on the X chromosome, although this is mainly limited to comparisons of whole flies or body segments containing the reproductive organs.The brain and head also differ from other tissues in that their male-biased genes are significantly closer to binding sites of the dosage compensation complex.We propose that the interplay of dosage compensation and sex-specific regulation can explain the observed differences between tissues and reconcile disparate results reported in previous studies.
Affiliation: Faculty of Biology, Ludwig Maximilian University of Munich, Planegg, Germany.Show MeSH
Mentions: To investigate possible differences in the level of dosage compensation among tissues, we compared the expression of the five DCC components among all tissues for which RNA-seq data were available. For three DCC components (MLE, MSL-2, and MSL-3), we observe the highest expression in the brain and head (fig. 5). This is especially true for MLE and MSL-2, which colocalize to the HAS at which dosage compensation is initiated (Straub et al. 2013). For both MLE and MSL-2, the expression level in brain and head is approximately 2-fold higher than that in other tissues (fig. 5). This suggests that gene expression in the brain and head may be particularly sensitive to DCC-induced upregulation.Fig. 5.—
Affiliation: Faculty of Biology, Ludwig Maximilian University of Munich, Planegg, Germany.