Variation in the X:Autosome Distribution of Male-Biased Genes among Drosophila melanogaster Tissues and Its Relationship with Dosage Compensation.
Bottom Line: Previous studies of Drosophila melanogaster found a general paucity of male-biased genes on the X chromosome, although this is mainly limited to comparisons of whole flies or body segments containing the reproductive organs.The brain and head also differ from other tissues in that their male-biased genes are significantly closer to binding sites of the dosage compensation complex.We propose that the interplay of dosage compensation and sex-specific regulation can explain the observed differences between tissues and reconcile disparate results reported in previous studies.
Affiliation: Faculty of Biology, Ludwig Maximilian University of Munich, Planegg, Germany.Show MeSH
Mentions: For the RNA-seq data sets that had a sufficient number of highly MBG, we examined the relationship between the degree of male bias and the distance to the nearest DCC binding site. This revealed that genes with weakly male-biased expression tend to be close to DCC binding sites, whereas those with strongly male-biased expression tend to be further away (fig. 4). This pattern held for Malpighian tubule, whole fly, and gonads (fig. 4).Fig. 4.—
Affiliation: Faculty of Biology, Ludwig Maximilian University of Munich, Planegg, Germany.