Variation in the X:Autosome Distribution of Male-Biased Genes among Drosophila melanogaster Tissues and Its Relationship with Dosage Compensation.
Bottom Line: Previous studies of Drosophila melanogaster found a general paucity of male-biased genes on the X chromosome, although this is mainly limited to comparisons of whole flies or body segments containing the reproductive organs.The brain and head also differ from other tissues in that their male-biased genes are significantly closer to binding sites of the dosage compensation complex.We propose that the interplay of dosage compensation and sex-specific regulation can explain the observed differences between tissues and reconcile disparate results reported in previous studies.
Affiliation: Faculty of Biology, Ludwig Maximilian University of Munich, Planegg, Germany.Show MeSH
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Mentions: In the above analyses, all MBG were placed in one category, regardless of the extent of their male-biased expression. However, within the MBG there are some striking differences among tissues in the degree of male-biased expression. For the brain and head data sets, only a small proportion of genes (5–20%) show more than a 2-fold male bias in their expression. For all of the other data sets, this proportion is higher, ranging from 30% to 90% (fig. 3). Similarly, the proportion of genes with greater than 4- or 6-fold male bias is less in the brain and head than in all other tissues (fig. 3).Fig. 3.—
Affiliation: Faculty of Biology, Ludwig Maximilian University of Munich, Planegg, Germany.